Original Research

Published on 22 Nov 2024

Increasing sustainability and reproducibility of in vitro toxicology applications: serum-free cultivation of HepG2 cells

in In Vitro Toxicology

Luisa Marie Pfeifer
Janike Sensbach
Frederic Pipp
Daniela Werkmann
Philip Hewitt

Frontiers in Toxicology

doi 10.3389/ftox.2024.1439031

394 views

Review

Accepted on 11 Nov 2024

AI and ML-based Risk Assessment of Chemicals: Predicting carcinogenic risk from Chemicalinduced genomic instability

in In Vitro Toxicology

Ajay Vikram Singh
Preeti Bhardwaj
Peter Laux
Prachi Pradeep
madleen busse
andreas luch
akihiko hirose
Christopher J. Osgood
Michael W Stacey

Frontiers in Toxicology

doi 10.3389/ftox.2024.1461587

Original Research

Published on 06 Nov 2024

A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models

in In Vitro Toxicology

S. Marceli Leano
Wanderson De Souza
Rodrigo De Vecchi
Amanda Lopes
Tatiana Deliberador
Jose M. Granjeiro

Frontiers in Toxicology

doi 10.3389/ftox.2024.1474583

575 views

Original Research

Published on 05 Nov 2024

Use of serum-free media for peripheral blood mononuclear cell culture and the impact on T and B cell readouts

in In Vitro Toxicology

Stella Cochrane
Ouarda Saib
David Sheffield

Frontiers in Toxicology

doi 10.3389/ftox.2024.1462688

678 views

Original Research

Accepted on 30 Oct 2024

In Vitro Toxicological Evaluation of Pouched Portioned Oral Nicotine Products

in In Vitro Toxicology

Brian M Keyser
Robert Leverette
Reagan Mcrae
John Wertman
Tom Shutsky
Ken Szeliga
Patrudu Makena
Kristen G Jordan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452274

102 views

Original Research

Published on 24 Oct 2024

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

in In Vitro Toxicology

Christina Drake
Walter Zobl
Sylvia E. Escher

Frontiers in Toxicology

doi 10.3389/ftox.2024.1465704

305 views

Review

Published on 08 Oct 2024

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

in In Vitro Toxicology

Lynne T. Haber
Mark A. Bradley
Amanda N. Buerger
Holger Behrsing
Sabina Burla
Phillip W. Clapp
Scott Dotson
Casey Fisher
Keith R. Genco
Francis H. Kruszewski

Frontiers in Toxicology

doi 10.3389/ftox.2024.1431790

1,796 views

Original Research

Published on 05 Sep 2024

Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro

in In Vitro Toxicology

Tetsuhiro Tsujino
Tomoni Kasahara
Hideo Kawabata
Taisuke Watanabe
Koji Nishiyama
Yutaka Kitamura
Takao Watanabe
Hajime Okudera
Tomoharu Mochizuki
Takashi Ushiki

Frontiers in Toxicology

doi 10.3389/ftox.2024.1421184

863 views

Original Research

Published on 25 Jul 2024

Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells

in In Vitro Toxicology

Isabella Cattani-Cavalieri
Marina Trombetta-Lima
Hong Yan
Ana L. Manzano-Covarrubias
Hoeke A. Baarsma
Asmaa Oun
Melissa Mol van der Veen
Emily Oosterhout
Amalia M. Dolga
Rennolds S. Ostrom

Frontiers in Toxicology

doi 10.3389/ftox.2024.1412864

1,194 views
2 citations

Original Research

Published on 23 Jul 2024

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

in In Vitro Toxicology

Gelsomina Pillo
Federico Aldrovandi
Ada Mescoli
Giangabriele Maffei
Maria Grazia Mascolo
Monica Vaccari
Annamaria Colacci

Frontiers in Toxicology

doi 10.3389/ftox.2024.1389160

1,804 views

Correction

Published on 19 Jul 2024

Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

in In Vitro Toxicology

David Thorne
Damian McHugh
Liam Simms
K. Monica Lee
Hitoshi Fujimoto
Sara Moses
Marianna Gaca

Frontiers in Toxicology

doi 10.3389/ftox.2024.1460271

462 views

Review

Published on 17 Jul 2024

Unleashing the potential of cell painting assays for compound activities and hazards prediction

in In Vitro Toxicology

Floriane Odje
David Meijer
Elena von Coburg
Justin J. J. van der Hooft
Sebastian Dunst
Marnix H. Medema
Andrea Volkamer

Frontiers in Toxicology

doi 10.3389/ftox.2024.1401036

2,033 views
1 citation

Original Research

Published on 13 Jun 2024

Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products

in In Vitro Toxicology

Fiona Chapman
Luuk de Haan
Linda Gijzen
Wouter Strijker
Edgar Trelles Sticken
Sarah Jean Pour
Roman Wieczorek
Florian Haberstroh
Sandra Otte
Thomas Nahde

Frontiers in Toxicology

doi 10.3389/ftox.2024.1395670

1,982 views

Review

Published on 13 Jun 2024

Applying new approach methodologies to assess next-generation tobacco and nicotine products

in In Vitro Toxicology

David Thorne
Damian McHugh
Liam Simms
K. Monica Lee
Hitoshi Fujimoto
Sara Moses
Marianna Gaca

Frontiers in Toxicology

doi 10.3389/ftox.2024.1376118

2,473 views

Original Research

Published on 11 Apr 2024

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

in In Vitro Toxicology

Marjory Moreau
Liam Simms
Melvin E. Andersen
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Fiona Chapman
Karin Roewer
Sandra Otte
Jeffrey Fisher

Frontiers in Toxicology

doi 10.3389/ftox.2024.1373325

1,994 views
2 citations

Correction

Published on 25 Mar 2024

Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

in In Vitro Toxicology

Albert Braeuning
Patrick Balaguer
William Bourguet
Jordi Carreras-Puigvert
Katreece Feiertag
Jorke H. Kamstra
Dries Knapen
Dajana Lichtenstein
Philip Marx-Stoelting
Jonne Rietdijk

Frontiers in Toxicology

doi 10.3389/ftox.2024.1394396

682 views

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Articles

Increasing sustainability and reproducibility of in vitro toxicology applications: serum-free cultivation of HepG2 cells

AI and ML-based Risk Assessment of Chemicals: Predicting carcinogenic risk from Chemicalinduced genomic instability

A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models

Use of serum-free media for peripheral blood mononuclear cell culture and the impact on T and B cell readouts

In Vitro Toxicological Evaluation of Pouched Portioned Oral Nicotine Products

Assessment of pulmonary fibrosis using weighted gene co-expression network analysis

New approach methodologies (NAMs) for the in vitro assessment of cleaning products for respiratory irritation: workshop report

Inhibitory effects of NaF on mitochondrial energy generation in human platelets in vitro

Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

Unleashing the potential of cell painting assays for compound activities and hazards prediction

Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products

Applying new approach methodologies to assess next-generation tobacco and nicotine products

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project