Original Research

Published on 22 Jan 2024

A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons

Christian T. Michael
Sayed Ahmad Almohri
Jennifer J. Linderman
Denise E. Kirschner

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1283341

1,463 views
5 citations

Original Research

Published on 08 Jan 2024

Metabolic perturbation studies using a Nash Equilibrium model of liver machine perfusion: modeling oxidative stress and effect of glutathione supplementation

Angelo Lucia
Korkut Uygun

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1260315

566 views

Editorial

Published on 20 Dec 2023

Editorial: Integrative systems biology and big data for agricultural improvement and understanding

Liliana Fadul-Pacheco
Antony T. Vincent
Eric R. Paquet

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1347323

562 views

Original Research

Published on 13 Dec 2023

An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal

Steven A. Frank

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1276734

605 views

Hypothesis and Theory

Published on 05 Dec 2023

The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory

Amanda Densil
Mya Elisabeth George
Hala Mahdi
Andrew Chami
Alyssa Mark
Chantal Luo
Yifan Wang
Aribah Ali
Pengpeng Tang
Audrey Yihui Dong

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1274184

4,068 views

Original Research

Published on 20 Nov 2023

Fine tuning a logical model of cancer cells to predict drug synergies: combining manual curation and automated parameterization

Åsmund Flobak
John Zobolas
Miguel Vazquez
Tonje S. Steigedal
Liv Thommesen
Asle Grislingås
Barbara Niederdorfer
Evelina Folkesson
Martin Kuiper

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1252961

1,900 views
2 citations

Editorial

Published on 29 Sep 2023

Editorial: Virtual patients and digital twins in the systems analysis of drug discovery and development

Chen Zhao
Hua He
Huilin Ma

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1293076

974 views
1 citation

Editorial

Published on 29 Sep 2023

Editorial: Systems biology, women in science 2021/22: translational systems biology and in silico trials

Jane A. Leopold
Madhavi K. Ganapathiraju
Naveena Yanamala

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1293298

642 views

Editorial

Published on 22 Sep 2023

Editorial: Use of quantitative systems pharmacology pipelines to bridge in vitro and in vivo results in drug discovery

Federico Reali
Attila Csikász-Nagy
Gianluca Selvaggio

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1291610

1,003 views

Original Research

Published on 22 Sep 2023

Multilayered safety framework for living diagnostics in the colon

Sonia Mecacci
Lucía Torregrosa-Barragán
Enrique Asin-Garcia
Robert W. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1240040

2,373 views
1 citation

Review

Published on 19 Sep 2023

What’s next for computational systems biology?

Eberhard O. Voit
Ashti M. Shah
Daniel Olivença
Yoram Vodovotz

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1250228

3,721 views
2 citations

Original Research

Published on 18 Sep 2023

Systems biology platform for efficient development and translation of multitargeted therapeutics

Karim Azer
Irina Leaf

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1229532

2,207 views
1 citation

Original Research

Published on 23 Aug 2023

In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy

Sara Sommariva
Silvia Berra
Giorgia Biddau
Giacomo Caviglia
Federico Benvenuto
Michele Piana

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1207898

1,432 views
1 citation

Original Research

Published on 08 Aug 2023

A microbiota-epigenetic circuit controls systematic circadian programs in the gut epithelium

Junjie Ma
Jianglin Zhang
Zheng Kuang

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1175306

1,581 views
2 citations

Hypothesis and Theory

Published on 25 Jul 2023

Generating synthetic multidimensional molecular time series data for machine learning: considerations

Gary An
Chase Cockrell

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1188009

2,014 views
7 citations

Original Research

Published on 13 Jul 2023

Alzheimer’s disease protein relevance analysis using human and mouse model proteomics data

Cathy Shi
W. Kirby Gottschalk
Carol A. Colton
Sayan Mukherjee
Michael W. Lutz

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1085577

2,065 views
3 citations

Navigation group

Volumes

A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons

Metabolic perturbation studies using a Nash Equilibrium model of liver machine perfusion: modeling oxidative stress and effect of glutathione supplementation

Editorial: Integrative systems biology and big data for agricultural improvement and understanding

An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal

The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory

Fine tuning a logical model of cancer cells to predict drug synergies: combining manual curation and automated parameterization

Editorial: Virtual patients and digital twins in the systems analysis of drug discovery and development

Editorial: Systems biology, women in science 2021/22: translational systems biology and in silico trials

Editorial: Use of quantitative systems pharmacology pipelines to bridge in vitro and in vivo results in drug discovery

Multilayered safety framework for living diagnostics in the colon

What’s next for computational systems biology?

Systems biology platform for efficient development and translation of multitargeted therapeutics

In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy

A microbiota-epigenetic circuit controls systematic circadian programs in the gut epithelium

Generating synthetic multidimensional molecular time series data for machine learning: considerations

Alzheimer’s disease protein relevance analysis using human and mouse model proteomics data