Original Research

Published on 15 Mar 2024

Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IP3 production and degradation

in Integrative Cell and Computational Systems Physiology

Clara Octors
Ryan E. Yoast
Scott M. Emrich
Mohamed Trebak
James Sneyd

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1343006

969 views
1 citation

Mini Review

Published on 13 Mar 2024

Computational insights in cell physiology

in Integrative Cell and Computational Systems Physiology

Geneviève Dupont
Didier Gonze

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1335885

577 views

Original Research

Published on 08 Mar 2024

Uncertainty quantified discovery of chemical reaction systems via Bayesian scientific machine learning

in Translational Systems Biology and In Silico Trials

Emily Nieves
Raj Dandekar
Chris Rackauckas

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1338518

3,410 views
2 citations

Perspective

Published on 08 Mar 2024

Advancing precision medicine therapeutics for Parkinson’s utilizing a shared quantitative systems pharmacology model and framework

in Translational Systems Biology and In Silico Trials

Christopher Denaro
Diane Stephenson
Martijn L. T. M. Müller
Benedetto Piccoli
Karim Azer

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1351555

1,711 views

Perspective

Published on 08 Mar 2024

Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity

in Data and Model Integration

Patrick C. Kinnunen
Kenneth K. Y. Ho
Siddhartha Srivastava
Chengyang Huang
Wanggang Shen
Krishna Garikipati
Gary D. Luker
Nikola Banovic
Xun Huan
Jennifer J. Linderman

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1333760

1,029 views
1 citation

Specialty Grand Challenge

Published on 06 Mar 2024

Expanding our thought horizons in systems biology and medicine

in Systems Concepts, Theory and Policy in Biology and Medicine

Jennifer C. Lovejoy

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1385458

972 views

Original Research

Published on 01 Mar 2024

Assessing electrogenetic activation via a network model of biological signal propagation

in Integrative Systems Microbiology

Kayla Chun
Eric VanArsdale
Elebeoba May
Gregory F. Payne
William E. Bentley

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1291293

938 views
2 citations

Original Research

Published on 01 Mar 2024

Pareto task inference analysis reveals cellular trade-offs in diffuse large B-Cell lymphoma transcriptomic data

in Translational Systems Biology and In Silico Trials

Jonatan Blais
Julie Jeukens

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1346076

881 views

Perspective

Published on 27 Feb 2024

BioModels’ Model of the Year 2023

in Data and Model Integration

Rahuman S. Malik Sheriff
Hiroki Asari
Henning Hermjakob
Wolfgang Huber
Thomas Quail
Silvia D. M. Santos
Amber M. Smith
Virginie Uhlmann

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1363884

1,934 views

Original Research

Published on 15 Feb 2024

Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation

in Data and Model Integration

Ashti M. Shah
Ruben Zamora
Derek Barclay
Jinling Yin
Fayten El-Dehaibi
Meghan Addorisio
Tea Tsaava
Aisling Tynan
Kevin Tracey
Sangeeta S. Chavan

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1266279

875 views
2 citations

Editorial

Published on 02 Feb 2024

Editorial: Combining mechanistic modeling with machine learning to study multiscale biological processes

in Multiscale Mechanistic Modeling

Shayn Peirce-Cottler
Yoram Vodovotz

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1367549

788 views

Original Research

Published on 29 Jan 2024

Genome-scale flux balance analysis reveals redox trade-offs in the metabolism of the thermoacidophile Methylacidiphilum fumariolicum under auto-, hetero-and methanotrophic conditions

in Data and Model Integration

Alexis Saldivar
Patricia Ruiz-Ruiz
Sergio Revah
Cristal Zuñiga

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1291612

1,836 views
2 citations

Original Research

Published on 22 Jan 2024

A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons

in Translational Systems Biology and In Silico Trials

Christian T. Michael
Sayed Ahmad Almohri
Jennifer J. Linderman
Denise E. Kirschner

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1283341

1,463 views
5 citations

Original Research

Published on 08 Jan 2024

Metabolic perturbation studies using a Nash Equilibrium model of liver machine perfusion: modeling oxidative stress and effect of glutathione supplementation

in Translational Systems Biology and In Silico Trials

Angelo Lucia
Korkut Uygun

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1260315

566 views

Editorial

Published on 20 Dec 2023

Editorial: Integrative systems biology and big data for agricultural improvement and understanding

in Data and Model Integration

Liliana Fadul-Pacheco
Antony T. Vincent
Eric R. Paquet

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1347323

562 views

Original Research

Published on 13 Dec 2023

An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal

in Multiscale Mechanistic Modeling

Steven A. Frank

Frontiers in Systems Biology

doi 10.3389/fsysb.2023.1276734

605 views

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Articles

Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IP3 production and degradation

Computational insights in cell physiology

Uncertainty quantified discovery of chemical reaction systems via Bayesian scientific machine learning

Advancing precision medicine therapeutics for Parkinson’s utilizing a shared quantitative systems pharmacology model and framework

Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity

Expanding our thought horizons in systems biology and medicine

Assessing electrogenetic activation via a network model of biological signal propagation

Pareto task inference analysis reveals cellular trade-offs in diffuse large B-Cell lymphoma transcriptomic data

BioModels’ Model of the Year 2023

Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation

Editorial: Combining mechanistic modeling with machine learning to study multiscale biological processes

Genome-scale flux balance analysis reveals redox trade-offs in the metabolism of the thermoacidophile Methylacidiphilum fumariolicum under auto-, hetero-and methanotrophic conditions

A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons

Metabolic perturbation studies using a Nash Equilibrium model of liver machine perfusion: modeling oxidative stress and effect of glutathione supplementation

Editorial: Integrative systems biology and big data for agricultural improvement and understanding

An enhanced transcription factor repressilator that buffers stochasticity and entrains to an erratic external circadian signal