Frontiers in Pharmacology

Original Research

Accepted on 04 Apr 2025

Irisin Attenuates Cardiac Injury and Improves Prognosis in Rats with Hemorrhagic Shock by Maintaining Mitochondrial Homeostasis via the AMPK/Drp1 Pathway

Zheng Zhang
Zheng Zhang
Xiaofang Zou
Jiake Li
Yunfei Chi
Hailiang Bai
Bin Wei
Huiting Yu
Quanxi Zhang
Weihua Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560608

Review

Accepted on 04 Apr 2025

Harnessing Nutrients and Natural Products for Sustainable Drug Development Against Aging

Fuan Ding
Ying Yu
Yan Zhang
Shibo Wei
Jung Ho Han
Zhuo Li
Hong-Bo Jiang
Dongryeol Ryu
Wonyoung Park
Ki-Tae Ha

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579266

Mini Review

Accepted on 04 Apr 2025

Quantification of Endogenous and Therapeutic IgG Crossing the Kidney Barrier from Bloodstream to Urine

Barbara Eicher
Christoph Esslinger
Matthias Hillenbrand

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572739

Systematic Review

Accepted on 04 Apr 2025

Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis

Yongheng Zhou
Zitian He
Tianyu Xiang
Xiaoyan Cao
Huiling Cong
Qinggang Liu
Haoyu Sun
Limin Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586845

Original Research

Accepted on 04 Apr 2025

Esmolol Improves Sepsis Outcomes Through Cardiovascular and Immune Modulation

Da Jing
Li Xiong
Rong Zhang
Hong Fang
Lin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498227

Original Research

Accepted on 04 Apr 2025

Adverse reactions of four multi-targeted tyrosine kinase inhibitors: a descriptive analysis of the WHO-VigiAccess database

Lijun Li
Jiayu Bai
Xuelong Wen
Xuefan Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585862

Original Research

Accepted on 04 Apr 2025

Multiscale Screening and Identifying Specific Targets for Artesunate in Suppressing Bladder Cancer

Yi Yuan
Guangdi Chu
Qingyue Ma
Zhijuan Liang
Ye Liang
Haitao Niu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584502

Case Report

Accepted on 04 Apr 2025

Neoadjuvant therapy with ripretinib for gastrointestinal stromal tumor: a case report

Zicheng Zheng
Guanmo Liu
Jie Li
Yixuan He
Chenggang Zhang
Yihua Wang
Weiming Kang
Xin Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573610

Original Research

Accepted on 04 Apr 2025

Effect of the total flavonoids of Dracocephalum Moldavica L. on metabolic associated fatty liver disease in rats

Xiaoyu Sun
Min Jin
Qingqing Liang
Qian Wang
Hui Yu
Na Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549515

Original Research

Accepted on 04 Apr 2025

Drug-induced pancreatitis: a real-world analysis of the FDA Adverse Event Reporting System and network pharmacology

Xie Hao
Lin Jiang
Junya Peng
Haoyang Hu
Meifen Han
Bin Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564127

Original Research

Accepted on 04 Apr 2025

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

Yongxue Gu
Mengmeng Yang
Wenbin Wang
Lihua Li
Ying Ma
Wenshan Liu
Qiang Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571135

Original Research

Accepted on 04 Apr 2025

The Protective Role of Vitamin C against Linezolid Induced Hepato-Renal Toxicity in Rat Model

Shaimaa M Azzam
Hend M Anwar
Ahmed Altantewy
Marwa S M Diab
Halima Mohamed Ibrahim
Abdalrahman Mohammed Yousef
Fatma Sabry
Ibrahim Darwish
Kalidasan Kaliyamoorthy
Gad Elsayed Mohamed Salem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551062

Original Research

Published on 04 Apr 2025

Evaluating the anti-neuropathic effects of the thymol-loaded nanofibrous scaffold in a rat model of spinal cord injury

Roshanak Amirian
Pardis Mohammadi Pour
Hassan Maleki
Sajad Fakhri
Sedigheh Asgary
Mohammad Hossein Farzaei
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507397

136 views

Original Research

Published on 04 Apr 2025

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

Wang Yu
Su Jie
Gao Su
Niu Zhuangwei
Zhou Yiqing
Chen Suhong
Lv Guiyuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550357

Systematic Review

Published on 04 Apr 2025

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis

Xu Zhao
Xianhao Huo
Yizhen Meng
Ran Zhao
Xiaozhuo Liu
Jiancheng Chen
Zhiqi Mao
Mei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529647

139 views

Original Research

Published on 04 Apr 2025

MicroRNA-665 and its potential role in drug response and survival outcomes in multiple myeloma: a preliminary study

Rui Bergantim
Sara Peixoto da Silva
Vanessa Pinto
Joana M. Pereira
Diana Sousa
Fernanda Trigo
Rune Matthiesen
José E. Guimarães
M. Helena Vasconcelos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1465814

147 views

25,995 Publications

Volume 16 - 2025

Irisin Attenuates Cardiac Injury and Improves Prognosis in Rats with Hemorrhagic Shock by Maintaining Mitochondrial Homeostasis via the AMPK/Drp1 Pathway

Harnessing Nutrients and Natural Products for Sustainable Drug Development Against Aging

Quantification of Endogenous and Therapeutic IgG Crossing the Kidney Barrier from Bloodstream to Urine

Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis

Esmolol Improves Sepsis Outcomes Through Cardiovascular and Immune Modulation

Adverse reactions of four multi-targeted tyrosine kinase inhibitors: a descriptive analysis of the WHO-VigiAccess database

Multiscale Screening and Identifying Specific Targets for Artesunate in Suppressing Bladder Cancer

Neoadjuvant therapy with ripretinib for gastrointestinal stromal tumor: a case report

Effect of the total flavonoids of Dracocephalum Moldavica L. on metabolic associated fatty liver disease in rats

Drug-induced pancreatitis: a real-world analysis of the FDA Adverse Event Reporting System and network pharmacology

YX-112, a novel celastrol-derived PROTAC, inhibits the development of triple-negative breast cancer by targeting the degradation of multiple proteins

The Protective Role of Vitamin C against Linezolid Induced Hepato-Renal Toxicity in Rat Model

Evaluating the anti-neuropathic effects of the thymol-loaded nanofibrous scaffold in a rat model of spinal cord injury

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis

MicroRNA-665 and its potential role in drug response and survival outcomes in multiple myeloma: a preliminary study