Frontiers in Pharmacology

Volume 16 - 2025

Original Research

Accepted on 17 Jan 2025

Impact of Fluoxetine Exposure on Lymnaea stagnalis and Its Developing Eggs: Integrating Untargeted Lipidomics, Targeted Metabolomics, and Classical Risk Assessment

Diana Ilyaskina
Yumi Nakadera
Marja Lamoree
Joris M Koene
Pim Leonards

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1536438

Original Research

Accepted on 17 Jan 2025

Stachydrine targeting tumor-associated macrophages inhibit colorectal cancer liver metastasis by regulating the JAK2/STAT3 pathway

Yang Gui
Gengchen Xue
Yuyi Yuan
Jingbo Wang
Shuangjiao Deng
Fei Gao
Yushi Tian
Zhiqiang Zhao
Heng Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1514158

Original Research

Accepted on 17 Jan 2025

Discovery of Novel and Highly Potent Small Molecule Inhibitors Targeting FLT3-ITD for the Treatment of Acute Myeloid Leukemia Using Structure-Based Virtual Screening and Biological Evaluation

Kun Shi
Ye Hong
Huajing Liu
Yanming Zhang
Fengzhen Wang
Xiaotian Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511257

Original Research

Accepted on 17 Jan 2025

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

Zaishi Zhu
Zeling Huang
Chaofeng Zhang
Bo Xu
Hua Chen
Shuai Pei
Baofei Zhang
Lishi Jie
Xiaoqing Shi
Yu'ji'ang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501725

Original Research

Accepted on 17 Jan 2025

Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA's Adverse Event Reporting System Database

Qun Li
Wenya Shan
Saiwei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1415701

Original Research

Accepted on 17 Jan 2025

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

Qingshan Tang
Jiachen Dong
Feng Zhang
Dan Zhao
Qi Yang
Jiayu Wen
Yuhao Sun
Ji-Fu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1489210

Original Research

Accepted on 17 Jan 2025

EXTRACTION, GC-MS ANALYSIS, CYTOTOXIC, ANTI-INFLAMMATORY AND ANTICANCER POTENTIAL OF CANNABIS SATIVA FEMALE FLOWER; IN VITRO, IN VIVO AND IN SILICO

WAQAS SAFIR
Jinyao Li
Arif Malik
Haleema Saadia
Ayesha Zahid

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546062

Original Research

Accepted on 17 Jan 2025

Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways

Liya Liu
Ying Cheng
Guosheng Lin
Huifang Zheng
Xinran Zhang
Peilin Zhao
Meixuan Guo
Qihong Liu
Wenyi Fang
Wenrong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1495020

Original Research

Accepted on 17 Jan 2025

The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia

Kai Shen
Chenlu Yang
Huang Jie
Xiao Shuai
Ting Niu
Hongbing Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540409

Review

Accepted on 17 Jan 2025

SOX9: A Key Transcriptional Regulator in Organ Fibrosis

Yishuo Li
Yue Xing
Ning Liu
Bin Liu
Zhihui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507282

Original Research

Accepted on 17 Jan 2025

Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline

Ge Gao
Caipeng Lin
Ruibo Li
Xi Xie
Hai-Bin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540559

Original Research

Accepted on 17 Jan 2025

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

Meng Qiqi
Li Zhiping
He Xiaofeng
Luo Zhuohui
Hu Yingjie
Shen Xiao-Ling

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496511

Review

Published on 17 Jan 2025

The role of multiomics in revealing the mechanism of skin repair and regeneration

Shaoyan Shi
Xuehai Ou
Jafeng Long
Xiqin Lu
Siqi Xu
Gang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1497988

106 views

Volume 15 - 2024

Original Research

Published on 17 Jan 2025

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

Monika Jürgenson
Keerthana Chithanathan
Aivar Orav
Külli Jaako
Janeli Viil
Mithu Guha
Kalev Kask
Alexander Zharkovsky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505729

392 views

Original Research

Published on 17 Jan 2025

Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans

Ying Qi
Pengfei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463575

107 views

Clinical Trial

Published on 17 Jan 2025

Effects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial study

Aziz Eghbali
Aygin Eghbali
Neda Ashayeri
Fatemeh Fadayi
Kazem Ghaffari
Ali Ghasemi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1507996

223 views

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Volumes

Volume 16 - 2025

Impact of Fluoxetine Exposure on Lymnaea stagnalis and Its Developing Eggs: Integrating Untargeted Lipidomics, Targeted Metabolomics, and Classical Risk Assessment

Stachydrine targeting tumor-associated macrophages inhibit colorectal cancer liver metastasis by regulating the JAK2/STAT3 pathway

Discovery of Novel and Highly Potent Small Molecule Inhibitors Targeting FLT3-ITD for the Treatment of Acute Myeloid Leukemia Using Structure-Based Virtual Screening and Biological Evaluation

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA's Adverse Event Reporting System Database

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

EXTRACTION, GC-MS ANALYSIS, CYTOTOXIC, ANTI-INFLAMMATORY AND ANTICANCER POTENTIAL OF CANNABIS SATIVA FEMALE FLOWER; IN VITRO, IN VIVO AND IN SILICO

Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways

The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia

SOX9: A Key Transcriptional Regulator in Organ Fibrosis

Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

The role of multiomics in revealing the mechanism of skin repair and regeneration

Volume 15 - 2024

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans

Effects of oral Lcarnitine supplementation on liver enzymes in pediatric acute lymphoblastic leukemia patients in the maintenance phase of treatment: a randomized clinical trial study