Case Report

Published on 19 Jun 2024

Case report and literature review: management of Paxlovid (nirmatrelvir/ritonavir)-induced acute tacrolimus toxicity in a patient with systemic lupus erythematosus

in Translational Pharmacology

Chenxiao Jiang
Xiaodi Yan
Peng Xia
Xuemei Luo
Haoyue Zheng
Hanwen Tong
Yun Liu
Huaijun Zhu
Peng Xu
Jun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364121

1,374 views

Clinical Trial

Published on 12 Jun 2024

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

in Translational Pharmacology

Yu-zhou Gui
Wei Wang
Qing-qing Wu
Qi-chen Ding
Hong-jie Qian
Qiu-bei Lu
Ying-jun Zhang
Yu-lei Zhuang
Li Deng
Ying-lin Zuo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1359939

1,209 views

Opinion

Published on 10 Jun 2024

Translational pathology in drug discovery

in Translational Pharmacology

Snježana Čužić
Maja Antolić
Anja Ognjenović
Vuk Milutinović
Sonja Vidović Iviš
Ines Glojnarić
Martina Bosnar
Lidija Požgaj
Ema Prenc
Vesna Eraković Haber

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1409092

796 views

Original Research

Published on 03 Jun 2024

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

in Translational Pharmacology

Rajbharan Yadav
Suzanne Schubbert
Patrick G. Holder
Eugene Y. Chiang
Nargess Kiabi
Liz Bogaert
Irene Leung
Rumana Rashid
Kendra N. Avery
Christine Bonzon

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1380000

1,792 views

Original Research

Published on 30 May 2024

Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms

in Translational Pharmacology

Jorge Berlanga-Acosta
Danay Cibrian
Juan Valiente-Mustelier
José Suárez-Alba
Ariana García-Ojalvo
Viviana Falcón-Cama
Baohong Jiang
Linlin Wang
Gerardo Guillén-Nieto

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1402138

3,070 views

Original Research

Published on 16 May 2024

Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4

in Translational Pharmacology

Mohamed Albadry
Jonas Küttner
Jan Grzegorzewski
Olaf Dirsch
Eva Kindler
Robert Klopfleisch
Vaclav Liska
Vladimira Moulisova
Sandra Nickel
Richard Palek

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1404938

1,739 views

Original Research

Published on 10 May 2024

In vivo imaging system (IVIS) therapeutic assessment of tyrosine kinase inhibitor-loaded gold nanocarriers for acute myeloid leukemia: a pilot study

in Translational Pharmacology

Raluca-Andrada Munteanu
Adrian Bogdan Tigu
Richard Feder
Andra-Sorina Tatar
Diana Gulei
Ciprian Tomuleasa
Sanda Boca

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1382399

1,604 views

Editorial

Published on 19 Apr 2024

Editorial: Use of Artificial Intelligence to evaluate drug-related behavioral changes in rodents

in Translational Pharmacology

Victor Fattori
Sara González-Rodríguez
Rafael González-Cano

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396454

813 views

Original Research

Published on 17 Apr 2024

A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis

in Translational Pharmacology

Kun Mi
Lei Sun
Lan Zhang
Aoran Tang
Xiaoyuan Tian
Yixuan Hou
Lingling Sun
Lingli Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378034

1,202 views

Methods

Published on 12 Apr 2024

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

in Translational Pharmacology

Kenneth R. Gundle
Karthik Rajasekaran
Jeffrey Houlton
Gary B. Deutsch
Thomas J. Ow
Robert G. Maki
John Pang
Cherie-Ann O. Nathan
Daniel Clayburgh
Jason G. Newman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367581

1,910 views
1 citation

Original Research

Published on 05 Apr 2024

Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

in Translational Pharmacology

James N. Bates
Paulina M. Getsy
Gregory A. Coffee
Santhosh M. Baby
Peter M. MacFarlane
Yee-Hsee Hsieh
Zackery T. Knauss
Jason A. Bubier
Devin Mueller
Stephen J. Lewis

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1336440

1,352 views
2 citations

Mini Review

Published on 25 Mar 2024

Impact of bariatric surgery on cytochrome P 450 enzyme activity

in Translational Pharmacology

Anna Pham
Patrick Chan
Angela Mercado
Jeffrey Wang
Zhijun Wang
Hajer Ibrahim
Hyma Gogineni
Ying Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1372950

1,084 views
1 citation

Mini Review

Published on 18 Mar 2024

The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future

in Translational Pharmacology

A. F. Roffel
E.-J. van Hoogdalem

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1369079

1,462 views

Original Research

Published on 07 Mar 2024

Assessing the relative contribution of CYP3A-and P-gp-mediated pathways to the overall disposition and drug-drug interaction of dabigatran etexilate using a comprehensive mechanistic physiological-based pharmacokinetic model

in Translational Pharmacology

Udomsak Udomnilobol
Wilasinee Dunkoksung
Watchara Sakares
Suree Jianmongkol
Thomayant Prueksaritanont

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356273

1,238 views

Review

Published on 04 Mar 2024

Pathophysiological aspects of transferrin-A potential nano-based drug delivery signaling molecule in therapeutic target for varied diseases

in Translational Pharmacology

Chang Li
Liya Zhou
Xunzhe Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342181

2,139 views
2 citations

Original Research

Published on 04 Mar 2024

Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives

in Translational Pharmacology

Endika Martín-Encinas
María Fuertes
Samuel Delgado-Hernández
Fernando García-Tellado
David Tejedor
Concepción Alonso

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1344042

1,119 views
1 citation

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Articles

Case report and literature review: management of Paxlovid (nirmatrelvir/ritonavir)-induced acute tacrolimus toxicity in a patient with systemic lupus erythematosus

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

Translational pathology in drug discovery

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms

Cross-species variability in lobular geometry and cytochrome P450 hepatic zonation: insights into CYP1A2, CYP2D6, CYP2E1 and CYP3A4

In vivo imaging system (IVIS) therapeutic assessment of tyrosine kinase inhibitor-loaded gold nanocarriers for acute myeloid leukemia: a pilot study

Editorial: Use of Artificial Intelligence to evaluate drug-related behavioral changes in rodents

A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

Impact of bariatric surgery on cytochrome P 450 enzyme activity

The application of Phase 0 and microtracer approaches in early clinical development: past, present, and future

Assessing the relative contribution of CYP3A-and P-gp-mediated pathways to the overall disposition and drug-drug interaction of dabigatran etexilate using a comprehensive mechanistic physiological-based pharmacokinetic model

Pathophysiological aspects of transferrin-A potential nano-based drug delivery signaling molecule in therapeutic target for varied diseases

Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives