Frontiers in Pharmacology | Translational Pharmacology

Clinical Trial

Accepted on 14 Apr 2025

Randomized, Double-blind, Placebo-Controlled Pilot Study of Metformin as an Adjunctive Therapy in Parkinson's disease

in Translational Pharmacology

Mostafa Bahaa
Hayam Ali Alrasheed
Thanaa A Elmasry
Eman I Elberri
Fedaa A Kotkata
Ramy M El Sabaa
Yasmine M Elmorsi
Mostafa M Kamel
Walaa A Negm
Amir O Hamouda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1497261

Original Research

Published on 14 Apr 2025

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

in Translational Pharmacology

Lorenzo Flori
Giulia Galgani
Giorgia Bray
Chiara Ippolito
Cristina Segnani
Carolina Pellegrini
Valentina Citi
Nunzia Bernardini
Alma Martelli
Vincenzo Calderone

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546456

330 views

Original Research

Published on 11 Apr 2025

Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier

in Translational Pharmacology

Sheng Ding
Yinghua Wei
Minglong Yang
Jinyi Shi
Kaiyuan Ren
Xinli Li
Zhuo Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589150

279 views

Original Research

Published on 10 Apr 2025

Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa

in Translational Pharmacology

Haoan He
Chao Lv
Yuhong Xie
Wei Li
Zihang Ling
Bin Cheng
Xiaoan Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559584

263 views

Original Research

Published on 09 Apr 2025

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations

in Translational Pharmacology

Abdul Mateen
Abad Khan
Ismail Khan
Saifullah Khan Khalil
Lateef Ahmad
Muhammad Junaid
Saqib Jehan
Muhammad Sohail Anwar
Muhammad Faheem
Abdul Salam

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1442762

263 views

Original Research

Published on 04 Apr 2025

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

in Translational Pharmacology

Wang Yu
Su Jie
Gao Su
Niu Zhuangwei
Zhou Yiqing
Chen Suhong
Lv Guiyuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550357

360 views

Systematic Review

Published on 04 Apr 2025

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis

in Translational Pharmacology

Xu Zhao
Xianhao Huo
Yizhen Meng
Ran Zhao
Xiaozhuo Liu
Jiancheng Chen
Zhiqi Mao
Mei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529647

437 views

Original Research

Published on 02 Apr 2025

Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

in Translational Pharmacology

Jazz Q. Stephens
Uriel Blas-Machado
Chrissy Sherrill
David Caudell
Nancy Kock
Ashley M. Davis
Jordyn M. Whitfield
Barry Hart
Kylie Kavanagh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537494

408 views

Review

Accepted on 31 Mar 2025

Advances in Biomaterials for Osteonecrosis Treatment

in Translational Pharmacology

Dapeng Wang
Jiannan Li
Yu Liu
Shuaishuai Wang
Shuo Duan
Zhiyang Liu
Shuaiwei Li
Guangwei Meng
Zhang Minglei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559810

Review

Accepted on 31 Mar 2025

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

in Translational Pharmacology

Ping Nie
Minghua Wang
Yan Mo
Hong Zhou
Qingbing Zha
Gendie E Lash
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526709

198 views

Original Research

Published on 31 Mar 2025

Anti-CTLA-and anti-PD-1 immune checkpoint inhibitor antibodies impair human sperm motility in-vitro

in Translational Pharmacology

Ilaria Cosci
Luca De Toni
Paolo Del Fiore
Andrea Di Nisio
Samuela Carraro
Claudia Maria Radu
Loris Bertazza
Simone Mocellin
Jacopo Pigozzo
Giovanna Crivellaro

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534975

667 views

Original Research

Accepted on 28 Mar 2025

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology

in Translational Pharmacology

Xuejing Zhu
Lei Zhang
Wenqian Cui
Liangjie Wang
Fengjing Xu
Mengyuan Liu
Shuangcheng Chen
Haowen Jiang
Zhiying He
Chang Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567639

112 views

Original Research

Published on 27 Mar 2025

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

in Translational Pharmacology

Dragoș Viorel Scripcariu
Cezar Cătălin Caratașu
Mitică Ciorpac
Teodora Alexa-Stratulat
Andrei Szilagyi
Cristian Răzvan Buga
Bogdan Ionuţ Dobrovăț
Lucian Eva
Andrei Daniel Timofte
Ludmila Lozneanu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1441011

658 views

Clinical Trial

Published on 26 Mar 2025

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of HEC113995PA·H2O, a novel dual-acting serotonergic antidepressant, in healthy subjects

in Translational Pharmacology

Xue Wu
Qingqing Wu
Qichen Ding
Yulei Zhuang
Lin Luo
Yingjun Zhang
Li Deng
Chuanfei Jin
Xue Li
Zhangma Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1500974

430 views

Original Research

Published on 26 Mar 2025

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway

in Translational Pharmacology

Yanwei Liu
Zhaoyu Fu
Xinyu Wang
Qifan Yang
Shun Liu
Dong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527316

677 views

Original Research

Published on 25 Mar 2025

Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta: in vivo and in vitro studies

in Translational Pharmacology

Lin Yang
Xue Yi
Meitao Duan
Ahmed Mahal
Binbin Chen
Zhiqiang Zhang
Jungang Ren
Ming Chen
Chen Meng
Moxun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560462

545 views