Frontiers in Pharmacology | Pharmacology of Ion Channels and Channelopathies

Original Research

Accepted on 10 Apr 2025

Early Reduction of Skin Potassium without Sodium Accumulation in the Pathogenesis of Salt Sensitivity in Primary Aldosteronism

in Pharmacology of Ion Channels and Channelopathies

Petr Mlejnek
František Liška
Jan Šilhavý
Kateřina Večerková
Miroslava Šimáková
Michal Pravenec
Theodore W Kurtz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575972

Original Research

Published on 10 Apr 2025

The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential

in Pharmacology of Ion Channels and Channelopathies

Aurélie Antunes
Jérôme Montnach
Kuldip Khakh
Ludivine Lopez
Baptiste Thomas
Barbara Ribeiro Oliveira-Mendes
Lucie Jaquillard
Denis Servent
Rémy Béroud
Charles J. Cohen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566312

146 views

Original Research

Accepted on 31 Mar 2025

Gaussian white noise stimulation as an alternative method to excite sensory neurons

in Pharmacology of Ion Channels and Channelopathies

Thomas Losgott
Klaus Schicker
Stefan Boehm
Isabella Salzer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561905

Review

Published on 28 Mar 2025

Role of voltage-gated chloride channels in epilepsy: current insights and future directions

in Pharmacology of Ion Channels and Channelopathies

Ming-Ming Ni
Jie-Yu Sun
Zheng-Qian Li
Jin-Chun Qiu
Chun-Feng Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560392

245 views

Review

Published on 26 Mar 2025

Sodium channels as a new target for pain treatment

in Pharmacology of Ion Channels and Channelopathies

Rui Chen
Yiran Liu
Liu Qian
Mingliang Yi
Hong Yin
Shun Wang
Bingbing Xiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573254

481 views

Review

Published on 24 Mar 2025

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells

in Pharmacology of Ion Channels and Channelopathies

Yuri M. Poluektov
Olga D. Lopina
Maria A. Strelkova
Iuliia D. Kuleshova
Alexander A. Makarov
Irina Yu. Petrushanko

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520927

490 views

Opinion

Published on 21 Mar 2025

When HERG-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible?

in Pharmacology of Ion Channels and Channelopathies

Zequn Zheng
Yongfei Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1535259

350 views

Review

Published on 21 Mar 2025

Recent insights on the impact of SWELL1 on metabolic syndromes

in Pharmacology of Ion Channels and Channelopathies

Mianhong Qin
Xuejie Yi
Ziqiang Duan
Bo Chang
Tao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552176

421 views

Original Research

Published on 07 Mar 2025

Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1

in Pharmacology of Ion Channels and Channelopathies

Bilal Çiğ

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549190

835 views

Original Research

Published on 28 Feb 2025

Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

in Pharmacology of Ion Channels and Channelopathies

O. Daniel Vera
Ramesh C. Mishra
Rayan Khaddaj-Mallat
Liam Hamm
Barak Almarzouq
Yong-Xiang Chen
Darrell D. Belke
Latika Singh
Heike Wulff
Andrew P. Braun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545050

709 views

Original Research

Published on 24 Feb 2025

Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

in Pharmacology of Ion Channels and Channelopathies

Simon Y. Graeber
Olaf Sommerburg
Yin Yu
Julian Berges
Stephanie Hirtz
Heike Scheuermann
Jasmin Berger
Julia Duerr
Marcus A. Mall

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537095

900 views

Review

Published on 30 Jan 2025

The enigmatic SLC26A6 multifunctional anion transporter: recent advances in structure-function relationship, pathophysiological significance and novel pharmacological inhibitors

in Pharmacology of Ion Channels and Channelopathies

Ursula E. Seidler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1536864

1,002 views

Original Research

Published on 06 Jan 2025

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties

in Pharmacology of Ion Channels and Channelopathies

Carlos Coll-Díez
Ana Marcela Giudici
Alberto Potenza
José Manuel González-Ros
José Antonio Poveda

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499383

592 views

Original Research

Published on 18 Nov 2024

Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators

in Pharmacology of Ion Channels and Channelopathies

Valeria Tomati
Valeria Capurro
Emanuela Pesce
Cristina Pastorino
Elvira Sondo
Mariateresa Lena
Anna Borrelli
Federico Cresta
Stefano Pantano
Francesca Collini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494327

1,196 views
1 citation

Original Research

Published on 14 Oct 2024

GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux

in Pharmacology of Ion Channels and Channelopathies

J Bundy
Y Ahmed
S Weller
J Nguyen
J Shaw
I Mercier
A Suryanarayanan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449256

1,397 views

Original Research

Published on 09 Oct 2024

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds

in Pharmacology of Ion Channels and Channelopathies

Arseniy S. Zhigulin
Mikhail Y. Dron
Oleg I. Barygin
Denis B. Tikhonov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467266

1,156 views