Original Research

Published on 15 Nov 2024

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

in Pharmacogenetics and Pharmacogenomics

Zhuan Yang
Wen Rui Tan
Qin Li
Ying Wang
Shijing Liu
Lu Chen
Yan Zhou
Chen Zeng
Yan Zeng
Yun Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454612

Original Research

Published on 14 Nov 2024

Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Jung Yoon Choi
Hoshik Kwon
Hyery Kim
Kyung Taek Hong
Youngeun Ma
Kyung-Nam Koh
Sunmin Yun
Keon Hee Yoo
Sang Hoon Song
Ho Joon Im

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1480657

Original Research

Accepted on 13 Nov 2024

Integration of pharmacogenetic data in Epic Genomic Module drives best practice alerts

in Pharmacogenetics and Pharmacogenomics

Kimberly Newsom
Bradley Hall
Katherine Martinez
Scott Nelson
Petr Starostik
Khoa Nguyen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1458095

107 views

Review

Published on 12 Nov 2024

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications

in Pharmacogenetics and Pharmacogenomics

Cigir Biray Avci
Bakiye Goker Bagca
Masoud Nikanfar
Leila Sabour Takanlou
Maryam Sabour Takanlou
Alireza Nourazarian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1442888

189 views

Original Research

Accepted on 08 Nov 2024

Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

in Pharmacogenetics and Pharmacogenomics

Yuejie Guo
Zhong Min
Luo Ning

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1490878

Original Research

Accepted on 04 Nov 2024

Metabolic Pathways, Genomic Alterations, and Post-Translational Modifications in Pulmonary Hypertension and Cancer as Therapeutic Targets and Biomarkers

in Pharmacogenetics and Pharmacogenomics

Xiujin Zhang
Zhiqing Fu
Haijun Wang
Li Sheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1490892

Original Research

Accepted on 04 Nov 2024

Investigation on Regulation of N-acetyltransferase 2 (NAT2) Expression by Nuclear Receptors in Human Hepatocytes

in Pharmacogenetics and Pharmacogenomics

Kyung U Hong
Anthony P Aureliano
Kennedy M Walls
David W Hein

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488367

Original Research

Accepted on 01 Nov 2024

Comparing Commercial Pharmacogenetic Testing Results and Recommendations for Antidepressants with Established CPIC Guidelines

in Pharmacogenetics and Pharmacogenomics

Tiffany T Nguyen
Emili Jeanne-Watts Leary
Joshua T Lee
Sanjay K Shukla
Sara A Griesbach

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1500235

Original Research

Published on 01 Nov 2024

Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction

in Pharmacogenetics and Pharmacogenomics

Jingwen Liu
Renbing Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495970

285 views

Original Research

Published on 01 Nov 2024

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

in Pharmacogenetics and Pharmacogenomics

Oscar I. Chávez-Arreola
Brissia Lazalde
Marisol López-López
Alberto Ortega-Vázquez
Quitzia L. Torres-Salazar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466394

191 views

Review

Accepted on 30 Oct 2024

Pharmacogenomics For Neurodegenerative Disorders -A Focused Review

in Pharmacogenetics and Pharmacogenomics

S Rehan Ahmad
Md. Zeyaullah
Mohammad Suhail Khan
Dr Abdullah Alshahrani
Abdelrhman A Galaleldin Altijani
Haroon Ali
Adam Dawria
Ali Mohieldin
Mohammad Shane Alam
Awad Osman Abdalla Mohamed

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1478964

Original Research

Published on 30 Oct 2024

The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

in Pharmacogenetics and Pharmacogenomics

Hady Yazbeck
Joe Youssef
Wassim Nasreddine
Abdullah El Kurdi
Nathalie Zgheib
Ahmad Beydoun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483723

231 views

Original Research

Published on 25 Oct 2024

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

in Pharmacogenetics and Pharmacogenomics

Haryana Y. Thomas
Ashlee N. Ford Versypt

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481768

312 views

Original Research

Published on 24 Oct 2024

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Jesús Alonso Gándara-Mireles
Ismael Lares-Asseff
Elio Aarón Reyes Espinoza
Verónica Loera Castañeda
Lourdes Patricia Córdova Hurtado
Flor de María Reyes Gutiérrez
Antonio Sandoval-Cabrera
Ignacio Villanueva Fierro
Julio Cesar Grijalva Ávila
Claudia Castro Arreola

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423049

289 views

Case Report

Published on 23 Oct 2024

Case report: Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics

in Pharmacogenetics and Pharmacogenomics

Belén García-Fariña
Lydia Rink
Virginia Santarini
Marco Westkemper
Christian Dohna-Schwake
Birte Möhlendick

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477755

631 views

Original Research

Published on 18 Oct 2024

The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response

in Pharmacogenetics and Pharmacogenomics

Wei Guo
Shi Zong
Tao Liu
Yi Chao
Kaichen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1476025

643 views

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Articles

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia

Integration of pharmacogenetic data in Epic Genomic Module drives best practice alerts

Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications

Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma

Metabolic Pathways, Genomic Alterations, and Post-Translational Modifications in Pulmonary Hypertension and Cancer as Therapeutic Targets and Biomarkers

Investigation on Regulation of N-acetyltransferase 2 (NAT2) Expression by Nuclear Receptors in Human Hepatocytes

Comparing Commercial Pharmacogenetic Testing Results and Recommendations for Antidepressants with Established CPIC Guidelines

Multi-omics association study integrating GWAS and pQTL data revealed MIP-1α as a potential drug target for erectile dysfunction

Allele frequencies and genotype distribution of three metformin transporter polymorphisms in Mexican population and their application in pharmacogenomics of type 2 diabetes

Pharmacogenomics For Neurodegenerative Disorders -A Focused Review

The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy

A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

Impact of single-nucleotide variants and individual characteristics on adverse events of L-asparaginase in children with acute lymphoblastic leukemia

Case report: Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics

The role of NOP58 in prostate cancer progression through SUMOylation regulation and drug response