Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 24 Mar 2025

Indole-3-acetic acid and chenodeoxycholic acid attenuate TLR4/NF-κB signaling and endoplasmic reticulum stress in valproic acid-induced neurotoxicity

in Neuropharmacology

Wedad S. Sarawi
Ahlam M. Alhusaini
Ghada S. Barwaished
Myasah M. Altamimi
Iman H. Hasan
Amjad S. Aljarboa
Norah K. Algarzae
Saleh A. Bakheet
Samiah A. Alhabardi
Sheikh F. Ahmad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570125

739 views

Opinion

Published on 24 Mar 2025

Diffusion constraints in neuroprotection: implications for clinical trials

in Neuropharmacology

Daniil P. Aksenov
Evan D. Doubovikov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542431

469 views
1 citation

Original Research

Accepted on 20 Mar 2025

In-vitro and In-vivo Exploration of Physostigmine Analogues to Understand the Mechanistic Crosstalk Between Klotho and Targets for Epilepsy

in Neuropharmacology

Mansi Dahalia
Haya Majid
Mohd Junaid Khan
Akshat Rathi
Mohd Ashif Khan
Imran Ahmd Khan
Mohammed Samim
Sayeed ur Rehman
MD SALIK NOORANI
Divya Vohora

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580943

227 views

Clinical Trial

Published on 20 Mar 2025

Alpha-lipoic acid alleviates oxidative stress and brain damage in patients with sevoflurane anesthesia

in Neuropharmacology

Kailun Gao
Ying Wu
Yan Zhang
Pei Dang
Huanjia Xue
Teng Li
Meiyan Zhou
Liwei Wang
Yangzi Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572156

545 views

Original Research

Published on 20 Mar 2025

Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice

in Neuropharmacology

Dilpreet Kour
Parul Khajuria
Kuhu Sharma
Alpa Sharma
Ankita Sharma
Syed Mudassir Ali
Priya Wazir
P. Ramajayan
Sanghapal D. Sawant
Utpal Nandi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525364

889 views

Original Research

Published on 19 Mar 2025

Teriparatide mitigates oxidative stress following spinal cord injury and enhances neurological recovery via the Nrf2/HO-1 signaling pathway

in Neuropharmacology

Xiong Moliang
Ai Gangtong
Feng Yun
Luo Caiguang
Deng Liang
Guo Jia
Xiao Qiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538857

535 views

Review

Published on 19 Mar 2025

Mitochondria and oxidative stress in epilepsy: advances in antioxidant therapy

in Neuropharmacology

Delphine Ji
Shanthini Mylvaganam
Prathyusha Ravi Chander
Mark Tarnopolsky
Keiran Murphy
Peter Carlen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505867

938 views

Opinion

Published on 19 Mar 2025

Mycotoxins and neuropsychiatric symptoms: possible role in special refugee populations

in Neuropharmacology

Malvina Hoxha
Mariagrazia Abbasciano
Giuseppina Avantaggiato
Bruno Zappacosta
Domenico Tricarico

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524152

530 views

Systematic Review

Published on 19 Mar 2025

The efficacy and safety of ginkgo terpene lactone preparations combined with antiplatelet aents in the treatment of ischemic stroke: a systematic review and meta-analysis

in Neuropharmacology

Hong Xu
Li Zeng
Li Liao
Xiaoxuan Li
Yan Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554207

497 views

Original Research

Published on 18 Mar 2025

Changes in the excitability of the medial parabrachial nucleus neurons during the chronic phase of pilocarpine-induced epilepsy in mice

in Neuropharmacology

Jinyu Xiao
Yinghui Gu
Chunhua Quan
Shulei Li
Jianmin Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474254

507 views

Original Research

Published on 14 Mar 2025

Evaluation of the neuroprotective potential of benzylidene digoxin 15 against oxidative stress in a neuroinflammation models induced by lipopolysaccharide and on neuronal differentiation of hippocampal neural precursor cells

in Neuropharmacology

Gilvânia A. Cordeiro
Jessica A. Faria
Leticia Pavan
Israel J. P. Garcia
Eduarda P. F. I. Neves
Gustavo Fernando de Frazao Lima
Hericles M. Campos
Pâmela Y. Ferreira
Paulo C. Ghedini
Elisa M. Kawamoto

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537720

684 views

Review

Published on 14 Mar 2025

The critical role of Sirt1 in ischemic stroke

in Neuropharmacology

Ziyi Jia
Ke Xu
Ruobing Li
Siyu Yang
Long Chen
Qianwen Zhang
Shulin Li
Xiaowei Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1425560

732 views

Original Research

Published on 13 Mar 2025

A real-world safety surveillance study of aducanumab through the FDA adverse event reporting system

in Neuropharmacology

Jingjing Huang
Xiaohong Long
Chunyong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522058

871 views

Original Research

Published on 13 Mar 2025

Randomized crossover clinical studies to assess abuse liability and nicotine pharmacokinetics of Velo Oral Nicotine pouches

in Neuropharmacology

Milly N. Kanobe
Christie Y. Powell
Makena Patrudu
Sarah A. Baxter
Melissa A. Tapia
John Darnell
Kristen Prevette
Alison G. Gibson
Sarah A. Ayoku
Leanne Campbell

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547073

1,826 views

Review

Published on 13 Mar 2025

Crosstalk between neuroinflammation and ferroptosis: Implications for Parkinson’s disease progression

in Neuropharmacology

Xiangyu Guo
Ran Wei
Xunzhe Yin
Ge Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528538

896 views

Original Research

Published on 12 Mar 2025

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway

in Neuropharmacology

Ziqiang Dong
Zhihui Dong
Lili Xu
Jinfeng Zhang
Lin Li
Rongjuan Wang
Xiaoyan Huang
Zhengqiang Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555079

752 views