Frontiers in Pharmacology | Neuropharmacology

Original Research

Published on 01 Apr 2025

A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons

in Neuropharmacology

Shuaifei Lu
Jiduo Shen
Xiaohui Jin
Changjing Zhang
Baoying Wang
Xianghua Liu
Ming Bai
Erping Xu
Xiangli Yan
Yucheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577676

450 views

Original Research

Published on 01 Apr 2025

A real-world pharmacovigilance study of adverse drug reactions associated with lecanemab and aducanumab based on WHO-VigiAccess and FAERS databases

in Neuropharmacology

Haoxiang Hu
Yunhan Zhao
Jiesheng Mao
Jianghai He
Yihan Zhang
Hongyu Ye
Xiaokai Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561020

513 views

Original Research

Accepted on 31 Mar 2025

Preventive Beneficial Effects of Cannabidiol in a Reserpine-Induced Progressive Model of Parkinsonism

in Neuropharmacology

Alvaro Costa Lima
Vinicius dos Santos Bioni
Marcela Becegato
Ywlliane S. R. Meurer
Debora Maria Cunha
Nathan A Aguiar
Fernanda Fiel Peres
Antonio Waldo Zuardi
Jaime Eduardo Hallak
Soraya S Smaili

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539783

148 views

Correction

Published on 31 Mar 2025

Corrigendum: Riluzole attenuates acute neural injury and reactive gliosis, hippocampal-dependent cognitive impairments and spontaneous recurrent generalized seizures in a rat model of temporal lobe epilepsy

in Neuropharmacology

Thomas Kyllo
Dominic Allocco
Laine Vande Hei
Heike Wulff
Jeffrey D. Erickson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592653

325 views

Original Research

Published on 31 Mar 2025

BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain

in Neuropharmacology

Mingming Xie
Dan Li
Haohao Zeng
Yulin Huang
Rui Xu
Zhen Wang
Jiacheng Yu
Yu’e Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575733

482 views

Original Research

Accepted on 28 Mar 2025

Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury

in Neuropharmacology

Hui Zhang
Can Zhu
Xingyu Zhou
Laifa Wang
Ling Demg
Binsheng He
Jianming Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581320

Systematic Review

Published on 28 Mar 2025

Effect and safety of perioperative ketamine/esketamine administration on postoperative pain and depression after breast cancer surgery: a systematic review and meta-analysis

in Neuropharmacology

Xinyi Sun
Chengwei Li
Lin Xu
Xiaojie Lin
Zheng Zhang
Chunlong Lin
Jianjun Li
Penghui Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532524

585 views

Systematic Review

Published on 27 Mar 2025

Effects of natural extracts in cognitive function of healthy adults: a systematic review and network meta-analysis

in Neuropharmacology

Zhi-yuan Wang
Ya-lu Deng
Ting-yuan Zhou
Yi Liu
Yu Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573034

716 views

Review

Published on 26 Mar 2025

The role and therapeutic potential of mitophagy in major depressive disorder

in Neuropharmacology

Xin-Nuan Shi
Chen-Yue Liu
Lin Li
Ming-Li Yao
Zhen Zhong
You-Ming Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564276

520 views

Review

Published on 26 Mar 2025

Exosomes: an innovative therapeutic target for cerebral ischemia-reperfusion injury

in Neuropharmacology

Yuan Yang
Yushan Duan
Jinxi Yue
Yue Yin
Yiming Ma
Xiaohong Wan
Jianlin Shao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552500

790 views

Original Research

Published on 26 Mar 2025

The astrocytic sigma-1 receptor constitutes in the fast antidepressant action of hypidone hydrochloride (YL-0919) in rodents

in Neuropharmacology

Jin-Feng Li
Hai-Xia Chang
Jia-Ning Zhao
Jin-Hao Bao
Wei Dai
Yun-Feng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564851

487 views

Systematic Review

Published on 26 Mar 2025

Ticagrelor or dipyridamole plus aspirin may be a promising antiplatelet therapy in patients with minor stroke or transient ischemic attack: a bayesian network meta-analysis

in Neuropharmacology

Shiran Qin
Si Gao
Dandan Xu
Li Zhang
Yanmei Luo
Sitong Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561564

607 views

Original Research

Published on 26 Mar 2025

Neuroprotective effects of arctigenin on cerebral ischemia-reperfusion injury in rats via the EPO/EPOR-JAK2-STAT5 signaling pathway

in Neuropharmacology

Shanshan Xu
Yuting Chen
Lingling Zhang
Wei Lu
Xu Chen
Ting Wang
Wenjie Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1503971

368 views

Original Research

Accepted on 25 Mar 2025

A ROS-Responsive, Aptamer-Targeted Graphene Oxide Nanocomposite for Site-Specific Glutathione Release in Cerebral Ischemia-Reperfusion Injury

in Neuropharmacology

Jingxin Mo
Meiying Li
Lili Wei
Wenxu Liu
Jiawen Wang
Qiujie Lu
Xianjue Chen
Lee Yong Lim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543870

115 views

Review

Published on 25 Mar 2025

Pharmacological mechanism and clinical application of ciprofol

in Neuropharmacology

Jianshun Zhou
Lifeng Wang
Zhaoying Zhong
Lei Yuan
Jinhua Huang
Ping Zou
Xiaohui Cao
Donglan Peng
Baozhen Liao
Jianqiang Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572112

450 views

Editorial

Published on 25 Mar 2025

Editorial: Pain and pain-related neuropsychiatric disorders: from mechanistic insights to innovative therapeutic strategies

in Neuropharmacology

Rosmara Infantino
Fabio Turco
Francesca Guida
Álvaro Llorente-Berzal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593890

412 views