Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Published on 24 Mar 2025

Chitinase 3-like protein 1 deficiency ameliorates drug-induced acute liver injury by inhibition of neutrophil recruitment through lipocalin-2

in Gastrointestinal and Hepatic Pharmacology

Ji Hye Kim
In Jun Yeo
Dong Ju Son
Sang Bae Han
Do Young Yoon
Dong Hun Lee
Jin Tae Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548832

637 views

Clinical Trial

Published on 24 Mar 2025

Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of Helicobacter pylori infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial

in Gastrointestinal and Hepatic Pharmacology

Yunfan Dong
Zhaotao Duan
Min Liu
Yanbing Ding
Guangxia Chen
Ruifang Wang
Xiaodan Xu
Lixia Ding
Qiang Zhan
Chengyu Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543352

791 views

Review

Published on 21 Mar 2025

Recent advancement in prevention against hepatotoxicity, molecular mechanisms, and bioavailability of gallic acid, a natural phenolic compound: challenges and perspectives

in Gastrointestinal and Hepatic Pharmacology

Peng Chen
Fanzhao Zou
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549526

601 views

Original Research

Published on 20 Mar 2025

Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

in Gastrointestinal and Hepatic Pharmacology

Jie Li
Xiujuan Yang
Xiaolong Lian
Baojian Li
Quhuan Ma
Lingling Yang
Guangmiao Gao
Yi Deng
Zhijun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557125

746 views

Original Research

Published on 19 Mar 2025

Akkermansia muciniphila ameliorates olanzapine-induced metabolic dysfunction-associated steatotic liver disease via PGRMC1/SIRT1/FOXO1 signaling pathway

in Gastrointestinal and Hepatic Pharmacology

Hui Chen
Ting Cao
ChenQuan Lin
ShiMeng Jiao
YiFang He
ZhenYu Zhu
QiuJin Guo
RenRong Wu
HuaLin Cai
BiKui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550015

687 views

Original Research

Published on 18 Mar 2025

A real-world disproportionality analysis of ripretinib data mining of the public version of FDA adverse event reporting system

in Gastrointestinal and Hepatic Pharmacology

Yingkai Feng
Xinyu Fa
Yifei Wang
Tao Zhang
Xuan Sun
Faping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469597

797 views

Original Research

Published on 17 Mar 2025

E1231/NMN protects against experimental metabolic syndrome: the central role of SIRT1 in modulating AKT/Nrf2/NFκB signaling

in Gastrointestinal and Hepatic Pharmacology

Elsayed A. Elmorsy
Hala A. Elashry
Abdullah S. Alkhamiss
Hamad Alsaykhan
Rabab S. Hamad
Mustafa Ahmed Abdel-Reheim
Mansour Alsoghair
Mariam S. Alharbi
Attia M. Gabr
Abousree T. Ellethy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558709

823 views

Original Research

Published on 14 Mar 2025

The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage

in Gastrointestinal and Hepatic Pharmacology

Chengyu Huang
Huichao Liang
Xiaohua Liang
Yueyi Liu
Jiaoling Wang
Haoran Jiang
Xinhui Kou
Jun Chen
Lili Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567210

860 views

Review

Published on 13 Mar 2025

Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Maofu Zhang
Jialin Zhong
Yanyun Shen
Zhongyang Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533141

490 views

Original Research

Published on 10 Mar 2025

The association between the gut microbiome and antituberculosis drug-induced liver injury

in Gastrointestinal and Hepatic Pharmacology

Shengfei Pei
Li Yang
Huixia Gao
Yuzhen Liu
Jianhua Lu
Er hei Dai
Chunyan Meng
Fumin Feng
Yuling Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512815

973 views

Original Research

Published on 05 Mar 2025

Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis

in Gastrointestinal and Hepatic Pharmacology

Wenya Zhu
Jialing Ma
Tingting Zhang
Mengmeng Zhu
Yajun Duan
Xiaoxiao Yang
Yuanli Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1522177

940 views

Review

Published on 04 Mar 2025

The potential of Sijunzi decoction in the fight against gastrointestinal disorders: a review

in Gastrointestinal and Hepatic Pharmacology

Liangjun Yang
Zheng Fang
Jiajie Zhu
Xiaofang Li
Bo Yang
Haiyan Liu
Feiyan Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1464498

1,049 views

Perspective

Published on 25 Feb 2025

Combining mechanistic modeling with machine learning as a strategy to predict inflammatory bowel disease clinical scores

in Gastrointestinal and Hepatic Pharmacology

Jaehee V. Shim
Markus Rehberg
Britta Wagenhuber
Piet H. van der Graaf
Douglas W. Chung

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1479666

1,336 views

Correction

Published on 19 Feb 2025

Corrigendum: Alcohol abstinence rescues hepatic steatosis and liver injury via improving metabolic reprogramming in chronic alcohol-fed mice

in Gastrointestinal and Hepatic Pharmacology

Aiwen Pi
Kai Jiang
Qinchao Ding
Shanglei Lai
Wenwen Yang
Jinyan Zhu
Rui Guo
Yibin Fan
Linfeng Chi
Songtao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554390

436 views

Original Research

Published on 18 Feb 2025

The median effective dose of ciprofol combined with a low-dose sufentanil for gastroscopy in obese or nonobese patients: a dose-finding study using Dixon’s up-and-down method

in Gastrointestinal and Hepatic Pharmacology

Jie Zhao
Yixiao Zhang
Guowei Su
Shaoyi Wang
Xiaolin Zhang
Guoxiang Wang
Gang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521715

551 views

Original Research

Published on 04 Feb 2025

Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic liver disease and steatohepatitis

in Gastrointestinal and Hepatic Pharmacology

Nikolina Canová
Jana Šípková
Mahak Arora
Zuzana Pavlíková
Tomáš Kučera
Ondřej Šeda
Tijana Šopin
Tomáš Vacík
Ondřej Slanař

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1476994

1,132 views