Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Original Research

Accepted on 18 Apr 2025

Albiflorin inhibits inflammation to improve liver fibrosis by targeting the CXCL12/CXCR4 axis in mice

in Gastrointestinal and Hepatic Pharmacology

Lingjie Meng
Huijing Lv
Anli Liu
Qian Cao
Xinyi Du
Chengjin Li
Qinggui Li
Qingqing Luo
Yi Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577201

Original Research

Accepted on 17 Apr 2025

Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice

in Gastrointestinal and Hepatic Pharmacology

Mi Zhang
Weigang Yuan
Chun Li
Chanyuan Chen
Xiang Liu
Zhilu Ma
Yifei Xiang
Guisha Chen
Chunxu Wang
Lei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574039

Review

Accepted on 16 Apr 2025

Knowledge landscape of macrophage research in liver fibrosis: A bibliometric review of the literature from WoSCC

in Gastrointestinal and Hepatic Pharmacology

Yanbo Li
Zhengmin Cao
Yanping Lu
Chao Lei
Wenliang Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571879

Original Research

Published on 16 Apr 2025

Inhibition of colorectal cancer cell growth by downregulation of M2-PK and reduction of aerobic glycolysis by clove active ingredients

in Gastrointestinal and Hepatic Pharmacology

Lin Liu
Gang Xing
Xiaoyi Guo
Hui Chen
Jian Li
Jian Wang
Yaling Li
Gang Liang
Minghua Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552486

313 views

Review

Published on 15 Apr 2025

Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection

in Gastrointestinal and Hepatic Pharmacology

Qin Ye
Zi-Hang Yu
Liang Nie
Fei-Xiang Wang
Guo Mu
Bin Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533628

163 views

Review

Accepted on 14 Apr 2025

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

in Gastrointestinal and Hepatic Pharmacology

Francesco Rettura
Christian Lambiase
Riccardo Tedeschi
Antonio Grosso
Lorenzo Cancelli
Angelo Ricchiuti
Andrea Bottari
Luca Giacomelli
Nicola De Bortoli
Massimo Bellini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538791

Systematic Review

Accepted on 14 Apr 2025

Efficacy and Safety of IL-23 p19 Inhibitors in the Treatment for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

in Gastrointestinal and Hepatic Pharmacology

Shuhan Wang
Hui Sun
Qian Wang
Han Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1490667

Review

Accepted on 14 Apr 2025

Gastrointestinal Injury in Cardiopulmonary Bypass: Current Insights and Future Directions Author names and affiliations

in Gastrointestinal and Hepatic Pharmacology

Qi-long Mao
Zi-Hang Yu
Liang Nie
Feixiang Wang
Yu-Hui Dong
Xiaofei Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542995

Original Research

Published on 14 Apr 2025

Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition

in Gastrointestinal and Hepatic Pharmacology

Roger Bentanachs
Lluïsa Miró
Patricia Ramírez-Carrasco
Rosa M. Sánchez
Manuel Bernabeu
Concepció Amat
Marta Alegret
Anna Pérez-Bosque
Núria Roglans
Juan C. Laguna

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547749

295 views

Review

Accepted on 09 Apr 2025

Targeting Fibroblast Growth Factor (FGF)-21 : A Promising Strategy for Metabolic Dysfunction-Associated Steatotic Liver Disease Treatment

in Gastrointestinal and Hepatic Pharmacology

Xinyue Cui
Quanhao Sun
Haiqiang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510322

Systematic Review

Accepted on 08 Apr 2025

The efficacy of aminosalicylates in acute radiation enteritis：a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Zhendong Wu
Chuyan Ni
Zhen Ye
Zhongsheng Xia
Li Li
Zhong Yu
Song Tang
Ying Lin
Wa Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544981

Review

Published on 08 Apr 2025

Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs

in Gastrointestinal and Hepatic Pharmacology

Aixi Zhong
Shuai Li
Jingxuan Zhang
Jingyuan Zhao
Chenhui Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545575

202 views

Original Research

Accepted on 07 Apr 2025

Sodium Aescinate Promotes Apoptosis of Pancreatic Stellate Cells and Alleviates Pancreatic Fibrosis by Inhibiting the PI3K/Akt/FOXO1 Signaling Pathways

in Gastrointestinal and Hepatic Pharmacology

Qing-Yun Wang
Bai-Yan Xu
Yi Wang
Yan-Mei Lin
Lin-Fu Zheng
Gang Liu
Da-Zhou Li
Chuan-Shen Jiang
Wen Wang
Xiang-Peng Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554260

103 views

Original Research

Accepted on 07 Apr 2025

Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice

in Gastrointestinal and Hepatic Pharmacology

Rui Tang
Quan Ji
Pengyuan Kang
Ling Jiang
Yuan Liu
Pengyu Miao
Xiaofan Xu
Mingxi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572906

Systematic Review

Accepted on 07 Apr 2025

Assessing the Therapeutic Potential of Rutin in Alleviating Symptoms of Inflammatory Bowel Disease: A Meta-Analysis

in Gastrointestinal and Hepatic Pharmacology

Ruicheng Yan
Zhenkai Zou
Fanglian Zhang
Zhigang Pan
Jinyao Xu
Xuanyi Li
Xiangjun Sun
Xufeng Wang
Feng Qin
Abulikemu Abulizi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539469

Review

Published on 07 Apr 2025

Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression

in Gastrointestinal and Hepatic Pharmacology

Roohi Chaudhary
Ralf Weiskirchen
Marcelo Ehrlich
Yoav I. Henis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580500

233 views