Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 19 Feb 2025

Harnessing machine learning and AI-driven analytics to identify novel drug targets and predict chemotherapy efficacy in NSCLC

in Experimental Pharmacology and Drug Discovery

Shaojia Qin
Biyu Deng
Dan Mo
Zhengyou Zhang
Xuan Wei
Zhougui Ling

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555040

842 views

Original Research

Published on 19 Feb 2025

Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head

in Experimental Pharmacology and Drug Discovery

Jie Xu
Wei Deng
Xun Zhu
Deyu Han
Yu Zheng
Qun Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508971

603 views

Original Research

Published on 18 Feb 2025

Mechanism of PAVA-induced toxicity and inflammation in a cocultured skin cell model

in Experimental Pharmacology and Drug Discovery

Yunyang Song
Wenjie Cheng
Zhen Wang
Tianqi Zhou
Fanghui Wu
Yifeng Yin
Dan Xu
Yanli Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531459

555 views

Original Research

Published on 18 Feb 2025

Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells

in Experimental Pharmacology and Drug Discovery

Qi Yang
Dan Zhao
Linjie Ju
Peng Cao
Jifu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524277

1,231 views

Original Research

Accepted on 17 Feb 2025

PDP1 related ferroptosis risk signature indicates distinct immune microenvironment and prognosis of breast cancer patients

in Experimental Pharmacology and Drug Discovery

Huifen Dang
Gongjian Zhu
Chen Gao
Yingxia Tian
Yingxia Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1551325

Original Research

Published on 14 Feb 2025

Zebularine showed anti-tumor efficacy in clear cell renal cell carcinoma

in Experimental Pharmacology and Drug Discovery

Haoyu Xu
Senlin Peng
Junwu Li
Yuanyuan Bai
Guozhi Zhao
Simin Liang
Wei Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531056

771 views

Original Research

Published on 14 Feb 2025

COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma

in Experimental Pharmacology and Drug Discovery

Jiao Zhang
Rui Zi
Ping Hu
Zongying Jiang
Ye Lv
Haixia Zhang
Yanjiao Zhao
Yan Wang
Lujun Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543193

689 views

Original Research

Published on 14 Feb 2025

Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects

in Experimental Pharmacology and Drug Discovery

Yasaman Ahmadpour
Gholamreza Bahrami
Elham Arkan
Fatemeh Abbaszadeh
Faranak Aghaz
Sajad Fakhri
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533025

895 views

Review

Published on 13 Feb 2025

The role and application of bioinformatics techniques and tools in drug discovery

in Experimental Pharmacology and Drug Discovery

Shujun Zhang
Kaijie Liu
Yafeng Liu
Xinjun Hu
Xinyu Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547131

2,798 views

Review

Published on 13 Feb 2025

Recent development of mitochondrial metabolism and dysfunction in osteoarthritis

in Experimental Pharmacology and Drug Discovery

Pengchao Guo
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel
Zhijun Pan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538662

1,559 views
1 citation

Original Research

Published on 13 Feb 2025

Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy

in Experimental Pharmacology and Drug Discovery

Nicolas Macri
Luana Mendonça Dias
Ana Claudia Pavarina
Walter L. Siqueira
Felipe Fornias Sperandio

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538520

743 views

Original Research

Published on 13 Feb 2025

Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts

in Experimental Pharmacology and Drug Discovery

Marcus M. Ilg
Alice R. Lapthorn
Sophie L. Harding
Tariq Minhas
Gouri Koduri
Stephen A. Bustin
Selim Cellek

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526495

1,752 views

Original Research

Published on 13 Feb 2025

Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM

in Experimental Pharmacology and Drug Discovery

Xiaofeng Zhou
Zhifang Liu
Weixiong Zhang
Lin Dai
Tao Chen
Zexiong Lin
Hong Pan
Qi Qi
Henry Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530268

610 views

Methods

Published on 11 Feb 2025

KGRDR: a deep learning model based on knowledge graph and graph regularized integration for drug repositioning

in Experimental Pharmacology and Drug Discovery

Huimin Luo
Hui Yang
Ge Zhang
Jianlin Wang
Junwei Luo
Chaokun Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1525029

714 views

Review

Published on 11 Feb 2025

New strategies to enhance the efficiency and precision of drug discovery

in Experimental Pharmacology and Drug Discovery

Qi An
Liang Huang
Chuan Wang
Dongmei Wang
Yalan Tu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550158

1,352 views

Review

Published on 11 Feb 2025

Hepatobiliary organoid research: the progress and applications

in Experimental Pharmacology and Drug Discovery

Rui-Qi Zou
Yu-Shi Dai
Fei Liu
Si-Qi Yang
Hai-Jie Hu
Fu-Yu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1473863

1,341 views