Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 10 Mar 2025

Prediction of adverse drug reactions based on pharmacogenomics combination features: a preliminary study

in Experimental Pharmacology and Drug Discovery

Mingxiu He
Yiyang Shi
Fangfang Han
Yongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1448106

687 views

Original Research

Published on 10 Mar 2025

Antimicrobial photodynamic therapy with 5-aminolevulinic acid plus antibiotics: a promising treatment for tibial osteomyelitis caused by drug-resistant bacteria

in Experimental Pharmacology and Drug Discovery

Ju Zuo
Feiyan Kong
Xiyu Wang
Tianyu Wang
Jianxi Zhao
Zhanjuan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566744

462 views

Original Research

Published on 10 Mar 2025

Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway

in Experimental Pharmacology and Drug Discovery

Yawei Tian
Huiming Liu
Xiaoxue Bao
Yukun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539411

1,227 views

Editorial

Published on 07 Mar 2025

Editorial: Machine learning advancements in pharmacology: transforming drug discovery and healthcare

in Experimental Pharmacology and Drug Discovery

Moom Rahman Roosan
Ramgopal Mettu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583486

704 views

Correction

Published on 07 Mar 2025

Corrigendum: Novel chemical scaffolds to inhibit the neutral amino acid transporter B0AT1 (SLC6A19), a potential target to treat metabolic diseases

in Experimental Pharmacology and Drug Discovery

Aditya Yadav
Nishank Shah
Praveen Kumar Tiwari
Kiran Javed
Qi Cheng
Indrapal Singh Aidhen
Stefan Bröer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485054

666 views

Original Research

Published on 07 Mar 2025

Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors

in Experimental Pharmacology and Drug Discovery

Junmin Dong
Xiaohua Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534707

547 views

Mini Review

Published on 07 Mar 2025

Therapeutic modulation of protein RBM3 for ischemic stroke treatment

in Experimental Pharmacology and Drug Discovery

Paulo Ávila-Gómez
Alba Vieites-Prado
Clara Correa-Paz
Lucía Del Pozo-Filíu
Nuria Palomar-Alonso
Francisco Campos
Esteban López-Arias

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555115

519 views

Editorial

Published on 06 Mar 2025

Editorial: Cellular and molecular mechanisms in metabolic disorders: role of inflammation and oxidative stress

in Experimental Pharmacology and Drug Discovery

Munkhtuya Tumurkhuu
Shahnawaz Ali Bhat
Md Zakir Hossain
Mohammad Shafiq
Md Saquib Hasnain
Amit Kumar Nayak
Syed Anees Ahmed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580553

643 views
1 citation

Original Research

Published on 06 Mar 2025

Adverse event profile of lomustine and temozolomide: a descriptive analysis from WHO-VigiAccess

in Experimental Pharmacology and Drug Discovery

Hua Luo
Shaohua Fan
Lu Liang
Youfu He
Jiangjie Chen
Chenghao Xu
Jing Zhu
Liwei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534802

584 views

Original Research

Published on 06 Mar 2025

Ursodeoxycholic and chenodeoxycholic bile acids alleviate endotoxininduced acute lung injury in rats by modulating aquaporin expression and pathways associated with apoptosis and inflammation

in Experimental Pharmacology and Drug Discovery

Tatjana Milivojac
Milkica Grabež
Ljiljana Amidžić
Alma Prtina
Aleksandra Krivokuća
Ugljesa Malicevic
Maja Barudžija
Milka Matičić
Snežana Uletilović
Nebojša Mandić-Kovačević

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1484292

560 views

Original Research

Published on 05 Mar 2025

Obesity promotes immunotherapy efficacy by up-regulating the glycolytic-mediated histone lactacylation modification of CD8+ T cells

in Experimental Pharmacology and Drug Discovery

Kai-Xuan Wang
Dong-Min Shi
Xiao-Li Shi
Jing-Yuan Wang
Xing-Hao Ai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533464

1,286 views

Review

Published on 05 Mar 2025

Advanced materials for cancer treatment and beyond

in Experimental Pharmacology and Drug Discovery

Lei Zhang
Yanan Wang
Yangjia Li
Zhe-Sheng Chen
Chaohua Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557155

548 views

Original Research

Published on 05 Mar 2025

Efficient substructure feature encoding based on graph neural network blocks for drug-target interaction prediction

in Experimental Pharmacology and Drug Discovery

Guojian Deng
Changsheng Shi
Ruiquan Ge
Riqian Hu
Changmiao Wang
Feiwei Qin
Cheng Pan
Haixia Mao
Qing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553743

549 views

Original Research

Published on 05 Mar 2025

Novel selective glucocorticoid receptor modulator GRM-01 demonstrates dissociation of anti-inflammatory effects from adverse effects on glucose and bone metabolism

in Experimental Pharmacology and Drug Discovery

Florian Jakob
Stephanie Hennen
Michael Gautrois
Feras Khalil
Andrew Lockhart

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542351

1,356 views

Review

Published on 04 Mar 2025

Recent advances in the multifaceted mechanisms of catalpol in treating osteoporosis

in Experimental Pharmacology and Drug Discovery

Na Li
Xiaoying Mu
Shudong Zhang
Huaxin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560715

714 views

Original Research

Accepted on 28 Feb 2025

Innovative application of mefloquine and methacycline in combating Tet(X3/X4)-positive Escherichia coli infections

in Experimental Pharmacology and Drug Discovery

Yonglin Zhou
Qianyu Zhou
Jinjing Xue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542729