Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Review

Published on 20 Mar 2025

MEPED as salvage therapy for relapsed/refractory Hodgkin’s lymphoma incorporating edited non-oncogene addiction: mTOR as a bottleneck

in Experimental Pharmacology and Drug Discovery

Dennis Christoph Harrer
Florian Lüke
Tobias Pukrop
Lina Ghibelli
Albrecht Reichle
Daniel Heudobler

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553331

528 views

Review

Published on 19 Mar 2025

The potential of ARL4C and its-mediated genes in atherosclerosis and agent development

in Experimental Pharmacology and Drug Discovery

Dan Liu
Jie Wang
Shuangshuang Zhang
Hongfei Jiang
Yudong Wu
Chao Wang
Wujun Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513340

635 views

Systematic Review

Published on 19 Mar 2025

Prognostic and clinicopathological roles of circular RNA expression in chemoresistance in head and neck squamous cell carcinoma: a systematic review

in Experimental Pharmacology and Drug Discovery

Sayan Kumar Das
Sameer Khasbage
Ashim Mishra
Babban Jee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502107

725 views

Original Research

Published on 19 Mar 2025

Transdermal administration of herbal essential oil alleviates high-fat diet-induced obesity by regulating metabolism and gut microbiota

in Experimental Pharmacology and Drug Discovery

Zu-Wen Ye
Qi-Yue Yang
Dong-Hua Yang
Qiao-Hong Lin
Xiao-Xia Liu
Feng-Qin Li
Fang-Fang Yan
Ping Luo
Si Qin
Fang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565030

571 views

Original Research

Published on 19 Mar 2025

Unraveling human transferrin-tryptamine interactions: a computational and biophysical approach to Alzheimer’s disease therapeutics

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Mohammed S. Alshammari
Taghreed A. Majrashi
Azna Zuberi
Moyad Shahwan
Akhtar Atiya
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540736

470 views

Original Research

Published on 19 Mar 2025

Ethanol extract of Portulaca oleracea L. mitigates atherosclerosis through modulation of cholesterol efflux and uptake pathways

in Experimental Pharmacology and Drug Discovery

Bin Chen
Shanshan Sun
Jialei Fu
Ling Ge
Wei Nie
Peina Zhou
Peng Cao
Qian Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550812

741 views

Editorial

Published on 19 Mar 2025

Editorial: Targeting cellular signalling pathways for disease therapy: the potential of cellular reprogramming and protein kinase inhibitors

in Experimental Pharmacology and Drug Discovery

Vanessa Marensi
Pedro Fontes Oliveira
Ariane Zamoner

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580686

402 views

Editorial

Published on 19 Mar 2025

Editorial: Old drugs: confronting recent advancements and challenges

in Experimental Pharmacology and Drug Discovery

Anna Wiktorowska-Owczarek
Diego Iacono
Magdalena Jasińska-Stroschein

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565890

498 views

Original Research

Accepted on 18 Mar 2025

The Effects of Ondansetron on Diabetes and High Fat Diet-Induced Liver Disease: A Critical Role for Protein Tyrosine Phosphatase 1B

in Experimental Pharmacology and Drug Discovery

Fawad Naeem
Maryam Aqeel
Muhammad Ammar Zahid
Mustafeez Mujtaba Babar
Fawad Shah
Abdelali Agouni
Sohaib Zafar Malik

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565628

137 views

Editorial

Published on 18 Mar 2025

Editorial: Education and training in pharmaceutical medicine, medicines development and regulation for scientists worldwide

in Experimental Pharmacology and Drug Discovery

Bernd Rosenkranz
Tomoya Tachi
Rolf Bass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544678

425 views

Original Research

Published on 17 Mar 2025

FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry

in Experimental Pharmacology and Drug Discovery

Manisha Singh
Shruthi Shanmukha
Raghda E. Eldesouki
Maged M. Harraz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537912

790 views

Original Research

Published on 17 Mar 2025

Resveratrol prevents gallstones in mice fed on a high fat diet via regulating PPAR-γ and SR-BI

in Experimental Pharmacology and Drug Discovery

Menglu Zhao
Boya Xie
Yuxuan Li
Haiqing Dong
Sijia Jiang
Tiantian Zhu
Xiaolong Wu
Chengchen Xu
Jian Zhang
Shiyi Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543865

877 views

Original Research

Published on 12 Mar 2025

Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron–glia crosstalk in Alzheimer’s disease

in Experimental Pharmacology and Drug Discovery

Artemizia Évora
Gonçalo Garcia
Ana Rubi
Eleonora De Vitis
Ana Teresa Matos
Ana Rita Vaz
Francesca Gervaso
Giuseppe Gigli
Alessandro Polini
Dora Brites

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474012

1,559 views

Original Research

Published on 12 Mar 2025

The role of TRAF2 in pan-cancer revealed by integrating informatics and experimental validation

in Experimental Pharmacology and Drug Discovery

Xizheng Wang
Jianfeng Yuan
Chenchen Zhang
Lingyu Kong
Enzhen Wu
Jianxin Guo
Zhongbing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563435

711 views

Review

Published on 12 Mar 2025

Advances in the study of death receptor 5

in Experimental Pharmacology and Drug Discovery

Xuan Qiao
Shuang Guo
Zhiyun Meng
Hui Gan
Zhuona Wu
Yunbo Sun
Shuchen Liu
Guifang Dou
Ruolan Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549808

463 views

Original Research

Published on 11 Mar 2025

Predicting protein–protein interactions in microbes associated with cardiovascular diseases using deep denoising autoencoders and evolutionary information

in Experimental Pharmacology and Drug Discovery

Senyu Zhou
Jian Luo
Mei Tang
Chaojun Li
Yang Li
Wenhua He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565860

353 views