Original Research

Published on 01 Oct 2024

PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

in Experimental Pharmacology and Drug Discovery

Maria Franz
Ravi Kumar Jairam
Lars Kuepfer
Nina Hanke

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1418870

668 views

Original Research

Published on 01 Oct 2024

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis

in Experimental Pharmacology and Drug Discovery

Xinyue Chen
Bo Zhou
Xinyi Jiang
Huayu Zhong
Aijing You
Taiyan Zou
Chengcheng Zhou
Xiaoxiao Liu
Yonghong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428925

374 views

Original Research

Published on 01 Oct 2024

KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis

in Experimental Pharmacology and Drug Discovery

Omar S. Al-Odat
Weam Othman Elbezanti
Krishne Gowda
Sandeep K. Srivastava
Shantu G. Amin
Subash C. Jonnalagadda
Tulin Budak-Alpdogan
Manoj K. Pandey

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1436786

707 views

Original Research

Published on 27 Sep 2024

Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis

in Experimental Pharmacology and Drug Discovery

Jennifer Venhorst
Roeland Hanemaaijer
Remon Dulos
Martien P. M. Caspers
Karin Toet
Joline Attema
Christa de Ruiter
Gino Kalkman
Tanja Rouhani Rankouhi
Jelle C. B. C. de Jong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1442752

610 views

Original Research

Published on 26 Sep 2024

Hyaluronic acid-solid lipid nano transporter serum preparation for enhancing topical tretinoin delivery: skin safety study and visual assessment of skin

in Experimental Pharmacology and Drug Discovery

Yasir Mehmood
Hira Shahid
Syeda Momena Rizvi
Usama Jamshaid
Numera Arshad
Mohammad Nur-e-Alam
Muhammad Delwar Hussain
Mohsin Kazi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1401594

616 views

Review

Published on 26 Sep 2024

The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

in Experimental Pharmacology and Drug Discovery

Sulogna Sarkar
Vani S. Prasanna
Pamelika Das
Hiroshi Suzuki
Kazuya Fujihara
Satoru Kodama
Hirohito Sone
Remya Sreedhar
Ravichandiran Velayutham
Kenichi Watanabe

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1447890

1,086 views

Original Research

Published on 25 Sep 2024

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

in Experimental Pharmacology and Drug Discovery

Renfei Du
Ahmed Y. Sanin
Wenjie Shi
Bing Huang
Ann-Christin Nickel
Andres Vargas-Toscano
Shuran Huo
Thomas Nickl-Jockschat
Claudia A. Dumitru
Wei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468920

721 views

Systematic Review

Published on 25 Sep 2024

Mapping the evolution and research landscape of ferroptosis-targeted nanomedicine: insights from a scientometric analysis

in Experimental Pharmacology and Drug Discovery

Siyang Cao
Yihao Wei
Yaohang Yue
Deli Wang
Jun Yang
Ao Xiong
Hui Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477938

792 views

Original Research

Published on 24 Sep 2024

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile

in Experimental Pharmacology and Drug Discovery

Ying Xiao
Xuefeng Hu
Wei Xing
Jie Yan
Ruhuan Wang
Xiaoqing Li
Jiahuan Li
Zhixin Zhang
Jingchao Sun
Junjun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464564

730 views

Original Research

Published on 23 Sep 2024

Mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis

in Experimental Pharmacology and Drug Discovery

Zhang Yong
Chen Mimi
Li Yingjie
Guo Yichen
Yu Yansu
Zhou Zhi
Lu Hui
Yao Si
Wu Chongming
Zhang Xiaopo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457467

1,198 views

Review

Published on 23 Sep 2024

Isoalantolactone: a review on its pharmacological effects

in Experimental Pharmacology and Drug Discovery

Guang Yang
Longfei Yang
Fei Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453205

465 views

Original Research

Published on 23 Sep 2024

Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling

in Experimental Pharmacology and Drug Discovery

Paris Avgoustou
Ameera B. A. Jailani
Aditya J. Desai
David J. Roberts
Ewan R. Lilley
Grant W. Stothard
Timothy M. Skerry
Gareth O. Richards

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455231

626 views

Original Research

Published on 23 Sep 2024

Design, synthesis and neuroprotective activity of compound derived from Gastrodia elata Blume and borneol

in Experimental Pharmacology and Drug Discovery

Lijuan Zhi
Huan Li
Baimei Shi
Tao Yu
Xiaoni Jia
Hui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437806

476 views

Original Research

Published on 23 Sep 2024

Computational insights into the inhibitory mechanism of type 2 diabetes mellitus by bioactive components of Oryza sativa L. indica (black rice)

in Experimental Pharmacology and Drug Discovery

Kashaf Rasool
Attya Bhatti
Abid Majeed Satti
Rehan Zafar Paracha
Peter John

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1457383

663 views

Original Research

Published on 20 Sep 2024

Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study

in Experimental Pharmacology and Drug Discovery

Elena Lucarini
Laura Benvenuti
Clelia Di Salvo
Vanessa D’Antongiovanni
Carolina Pellegrini
Giulia Valdiserra
Clara Ciampi
Luca Antonioli
Christian Lambiase
Lorenzo Cancelli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466824

730 views

Correction

Published on 20 Sep 2024

Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway

in Experimental Pharmacology and Drug Discovery

Yanni Lv
Jin Chen
Jinfang Hu
Yisong Qian
Ying Kong
Longsheng Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1465932

332 views

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Articles

PBPK-based translation from preclinical species to humans for the full-size IgG therapeutic efalizumab

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis

KS18, a Mcl-1 inhibitor, improves the effectiveness of bortezomib and overcomes resistance in refractory multiple myeloma by triggering intrinsic apoptosis

Integrating text mining with network models for successful target identification: in vitro validation in MASH-induced liver fibrosis

Hyaluronic acid-solid lipid nano transporter serum preparation for enhancing topical tretinoin delivery: skin safety study and visual assessment of skin

The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

Mapping the evolution and research landscape of ferroptosis-targeted nanomedicine: insights from a scientometric analysis

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile

Mangiferin ameliorates polycystic ovary syndrome in rats by modulating insulin resistance, gut microbiota, and ovarian cell apoptosis

Isoalantolactone: a review on its pharmacological effects

Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling

Design, synthesis and neuroprotective activity of compound derived from Gastrodia elata Blume and borneol

Computational insights into the inhibitory mechanism of type 2 diabetes mellitus by bioactive components of Oryza sativa L. indica (black rice)

Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study

Corrigendum: Nonmuscle myosin heavy chain IIA-mediated exosome release via regulation of the rho-associated kinase 1/myosin light chains/actin pathway