Original Research

Published on 16 Oct 2024

Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

in Experimental Pharmacology and Drug Discovery

Salma Sameh
Ahmed M. Elissawy
Eman Al-Sayed
Rola M. Labib
Hsueh-Wei Chang
Szu-Yin Yu
Fang-Rong Chang
Shyh-Chyun Yang
Abdel Nasser B. Singab

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1465055

1,270 views

Correction

Published on 16 Oct 2024

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

in Experimental Pharmacology and Drug Discovery

Alexander Vugler
James O’connell
Mai Anh Nguyen
Dietmar Weitz
Thomas Leeuw
Elizabeth Hickford
Alexander Verbitsky
Xiaoyou Ying
Markus Rehberg
Bruce Carrington

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1479557

312 views

Original Research

Published on 15 Oct 2024

The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair

in Experimental Pharmacology and Drug Discovery

Xian Wang
Yuetong Wang
Xianglin Zeng
Haoyu Lu
Dongqin Mo
Yuetao Li
Zhiqing Liu
Yude Huang
Kun Yu
Daiyou Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1471996

357 views

Correction

Accepted on 14 Oct 2024

Corrigendum: Novel chemical scaffolds to inhibit the neutral amino acid transporter B0AT1 (SLC6A19), a potential target to treat metabolic diseases.

in Experimental Pharmacology and Drug Discovery

Aditya Yadav
Nishank Shah
Praveen Tiwari
Kiran Javed
Qi Cheng
Indrapal Singh Aidhen
Stefan Broer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485054

Original Research

Published on 14 Oct 2024

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis

in Experimental Pharmacology and Drug Discovery

Ruiqiang Xie
Hongyan Xie
Hong Gao
Chunguang Xie
Haipo Yuan
Zhijun Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448505

811 views

Original Research

Published on 11 Oct 2024

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354

in Experimental Pharmacology and Drug Discovery

Tayla A. Rees
Benjamin J. Buttle
Zoe Tasma
Sung-Hyun Yang
Paul W. R. Harris
Christopher S. Walker

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463313

729 views

Correction

Accepted on 10 Oct 2024

Corrigendum: Ginkgolide C Alleviates Myocardial Ischemia/ Reperfusion-Induced Inflammatory Injury via Inhibition of CD40-NF-κB Pathway

in Experimental Pharmacology and Drug Discovery

Rui Zhang
Dan Han
Zhenyu Li
Chengwu Shen
Yahui Zhang
Jun Li
Genquan Yan
Shasha Li
Bo Hu
Jiangbing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492520

Original Research

Published on 10 Oct 2024

CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome

in Experimental Pharmacology and Drug Discovery

Hao Xu
Jin Xing
Lilin Cheng
Zhihan Wang
Liang Zhao
Li Ren
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1479480

408 views

Original Research

Published on 09 Oct 2024

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

in Experimental Pharmacology and Drug Discovery

Javier Sanchez
Christina Claus
Christine McIntyre
Tamara Tanos
Axel Boehnke
Lena E. Friberg
Siv Jönsson
Nicolas Frances

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472662

709 views

Original Research

Published on 09 Oct 2024

Identification of high-affinity Monoamine oxidase B inhibitors for depression and Parkinson’s disease treatment: bioinformatic approach of drug repurposing

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Pratibha Prasad
Dharmendra Kumar Yadav
Nojood Altwaijry
Mohd Shahnawaz Khan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1422080

525 views

Original Research

Published on 09 Oct 2024

The NEDD4/FLRT2 axis regulates NSCLC cell stemness

in Experimental Pharmacology and Drug Discovery

Yuping Yang
Fei Yan
Ziwei Gao
Houke Li
Shengke Wen
Qi Li
Jiayuan Li
Na Huang
Wei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459978

530 views

Original Research

Published on 09 Oct 2024

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

in Experimental Pharmacology and Drug Discovery

Debora Curci
Biljana Stankovic
Nikola Kotur
Letizia Pugnetti
Vladimir Gasic
Maurizio Romano
Branka Zukic
Giuliana Decorti
Gabriele Stocco
Marianna Lucafò

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448136

416 views

Original Research

Published on 09 Oct 2024

Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate

in Experimental Pharmacology and Drug Discovery

Cem Öziç
Erdal Ertaş
Mehmet Fırat Baran
Ayşe Baran
Elham Ahmadian
Aziz Eftekhari
Rovshan Khalilov
Elvin Aliyev
Mahmut Yıldıztekin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1482130

464 views

Original Research

Published on 08 Oct 2024

FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

in Experimental Pharmacology and Drug Discovery

Guoan Xiang
Qi Li
Di Lian
Chengcheng Su
Xin Li
Shoulong Deng
Lixin Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1469286

518 views

Review

Published on 03 Oct 2024

Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024)

in Experimental Pharmacology and Drug Discovery

Lili Wang
Shan Wang
Xuan Dai
Gaiyue Yue
Jiyuan Yin
Tianshu Xu
Hanfen Shi
Tianyuan Liu
Zhanhong Jia
Dieter Brömme

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483431

843 views

Original Research

Published on 01 Oct 2024

Xiaoyin-anshen formula alleviates psoriasis complicated by sleep disturbances by regulating melatonin, antioxidant enzymes, and pro-inflammatory cytokines in mice

in Experimental Pharmacology and Drug Discovery

Zebing Zhu
Qiang Yin
Xingwu Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427985

680 views

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Articles

Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles

Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

The single-strand DNA-binding protein SSB1 is involved in the expression of salivary gland radiation injury repair

Corrigendum: Novel chemical scaffolds to inhibit the neutral amino acid transporter B0AT1 (SLC6A19), a potential target to treat metabolic diseases.

Mitochondrial proteins as therapeutic targets in diabetic ketoacidosis: evidence from Mendelian randomization analysis

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354

Corrigendum: Ginkgolide C Alleviates Myocardial Ischemia/ Reperfusion-Induced Inflammatory Injury via Inhibition of CD40-NF-κB Pathway

CircFOXO3 upregulation mediates the radioresistance of glioblastoma by affecting cellular metabolome

Combining mathematical modeling, in vitro data and clinical target expression to support bispecific antibody binding affinity selection: a case example with FAP-4-1BBL

Identification of high-affinity Monoamine oxidase B inhibitors for depression and Parkinson’s disease treatment: bioinformatic approach of drug repurposing

The NEDD4/FLRT2 axis regulates NSCLC cell stemness

The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity

Synthesis and characterization of activated carbon-supported magnetic nanocomposite (MNPs-OLAC) obtained from okra leaves as a nanocarrier for targeted delivery of morin hydrate

FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression

Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014–2024)

Xiaoyin-anshen formula alleviates psoriasis complicated by sleep disturbances by regulating melatonin, antioxidant enzymes, and pro-inflammatory cytokines in mice