Original Research

Published on 24 Oct 2024

Deciphering quinazoline derivatives’ interactions with EGFR: a computational quest for advanced cancer therapy through 3D-QSAR, virtual screening, and MD simulations

in Experimental Pharmacology and Drug Discovery

Sirajudheen Anwar
Jowaher Alanazi
Nafees Ahemad
Shafaq Raza
Tahir Ali Chohan
Hammad Saleem

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1399372

403 views

Methods

Published on 24 Oct 2024

Effect of 5% lidocaine-medicated plaster in preventing chronic postsurgical pain after knee replacement: protocol for a randomized double-blind placebo-controlled trial

in Experimental Pharmacology and Drug Discovery

Junpeng Yuan
Huichan Xu
Jiongjiong Guo
Yan Li
Youjia Yu
Xiaohong Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486217

2,067 views

Original Research

Published on 24 Oct 2024

Characteristics of adverse reactions of three anti-glioma drugs in WHO-VigiAccess

in Experimental Pharmacology and Drug Discovery

Huadong Ke
Zicheng Zhang
Zhao Yu
Baiquan Zhang
Rui Chen
Qiang Zhou
Qian Guo
Xiaohui Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485067

245 views

Opinion

Published on 23 Oct 2024

The enigma of small heat shock protein phosphorylation

in Experimental Pharmacology and Drug Discovery

Matthias Gaestel

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486245

281 views

Original Research

Published on 23 Oct 2024

De novo design of mIDH1 inhibitors by integrating deep learning and molecular modeling

in Experimental Pharmacology and Drug Discovery

Dingkang Sun
Lulu Xu
Mengfan Tong
Zhao Wei
Weitong Zhang
Jialong Liang
Xueying Liu
Yuwei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491699

344 views

Original Research

Published on 23 Oct 2024

Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity

in Experimental Pharmacology and Drug Discovery

Manel Azzi
Ibtissam Laib
Abderrhmane Bouafia
Ifriqya Medila
Ali Tliba
Salah Eddine Laouini
Huda Alsaeedi
David Cornu
Mikhael Bechelany
Ahmed Barhoum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485525

583 views

Original Research

Published on 23 Oct 2024

Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

in Experimental Pharmacology and Drug Discovery

Ting Tai
Yuan-Yuan Shao
Yu-Qi Zheng
Li-Ping Jiang
Hao-Ru Han
Na Yin
Hao-Dong Li
Jin-Zi Ji
Qiong-Yu Mi
Li Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496639

801 views

Original Research

Published on 22 Oct 2024

Exploring the antioxidant and protective effects of Marsdenia thyrsiflora Hook.f. leaf extract against carbon tetrachloride-induced hepatic damage in rat models

in Experimental Pharmacology and Drug Discovery

Sushmita Saha
Abdulrahman Alshammari
Norah A. Albekairi
Tasniya Nahiyan Zulfiquar
Md Salman Shakil
Kakoli Rani Mondal
Milton Kumar Kundu
Milon Mondal
Mohammad S. Mubarak

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463922

348 views

Original Research

Published on 22 Oct 2024

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1

in Experimental Pharmacology and Drug Discovery

Yunxia Zhang
Xiaoxiao Wu
Ruoqi Li
Mengru Sui
Guoyin Li
Shuhua Fan
Mingsheng Yang
Qiuping Liu
Xiaomeng Liu
Changjing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467620

362 views

Original Research

Published on 22 Oct 2024

PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling

in Experimental Pharmacology and Drug Discovery

Ran Wu
Chun-Xiang Cao
Lu Cao
Jun Su
Ke-Man Liao
Huan Li
Qian Zhu
Shu-Yan Li
Min Li
Jia-Yi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492453

209 views

Original Research

Published on 22 Oct 2024

Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing

in Experimental Pharmacology and Drug Discovery

Jingji Wang
Kunrui Du
Chang Liu
Xiaoyu Chen
Wenming Ban
Guoqi Zhu
Jun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428907

729 views

Original Research

Accepted on 21 Oct 2024

Evaluation of Inhibitory mechanism of Pennisetum glaucum (Pearl Millet) Bioactive Compounds for Rheumatoid Arthritis: An In Vitro and Computational Approach

in Experimental Pharmacology and Drug Discovery

MARIA SHARIF
Peter John
Attya Bhatti
Rehan Zafar Paracha
Abid Majeed

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488790

162 views

Original Research

Published on 21 Oct 2024

Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

in Experimental Pharmacology and Drug Discovery

Daowei Huang
Jixia Yang
Qingwei Zhang
Xiaolei Zhou
Yanbo Wang
Zhenhua Shang
Jianqi Li
Baoyin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467028

341 views

Original Research

Published on 16 Oct 2024

Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment

in Experimental Pharmacology and Drug Discovery

Larysa Natrus
Olha Lisakovska
Anton Smirnov
Yuliia Osadchuk
Yuliia Klys

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477793

449 views

Correction

Published on 16 Oct 2024

Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines

in Experimental Pharmacology and Drug Discovery

Yudi Dong
Wei Gong
Zhongyan Hua
Bo Chen
Guifeng Zhao
Zhihui Liu
Carol J. Thiele
Zhijie Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1425039

220 views

Editorial

Published on 16 Oct 2024

Editorial: Modulation of immune function: drug discovery and translational application

in Experimental Pharmacology and Drug Discovery

Ruirong Tan
Junning Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1495815

218 views

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Articles

Deciphering quinazoline derivatives’ interactions with EGFR: a computational quest for advanced cancer therapy through 3D-QSAR, virtual screening, and MD simulations

Effect of 5% lidocaine-medicated plaster in preventing chronic postsurgical pain after knee replacement: protocol for a randomized double-blind placebo-controlled trial

Characteristics of adverse reactions of three anti-glioma drugs in WHO-VigiAccess

The enigma of small heat shock protein phosphorylation

De novo design of mIDH1 inhibitors by integrating deep learning and molecular modeling

Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity

Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

Exploring the antioxidant and protective effects of Marsdenia thyrsiflora Hook.f. leaf extract against carbon tetrachloride-induced hepatic damage in rat models

Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1

PACAP38 synergizes with irradiation to suppress the proliferation of multiple cancer cells via regulating SOX6/Wnt/β-catenin signaling

Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing

Evaluation of Inhibitory mechanism of Pennisetum glaucum (Pearl Millet) Bioactive Compounds for Rheumatoid Arthritis: An In Vitro and Computational Approach

Design, synthesis, and biological evaluation of 2,4-dimorpholinopyrimidine-5-carbonitrile derivatives as orally bioavailable PI3K inhibitors

Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment

Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines

Editorial: Modulation of immune function: drug discovery and translational application