Original Research

Published on 22 Jan 2024

Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer

in Experimental Pharmacology and Drug Discovery

Vicenç Ruiz de Porras
Adrià Bernat-Peguera
Clara Alcon
Fernando Laguia
Maria Fernández-Saorin
Natalia Jiménez
Ana Senan-Salinas
Carme Solé-Blanch
Andrea Feu
Mercedes Marín-Aguilera

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1331648

2,344 views
1 citation

Perspective

Published on 22 Jan 2024

Development of trofinetide for the treatment of Rett syndrome: from bench to bedside

in Experimental Pharmacology and Drug Discovery

Melissa Kennedy
Larry Glass
Daniel G. Glaze
Steve Kaminsky
Alan K. Percy
Jeffrey L. Neul
Nancy E. Jones
Daniela Tropea
Joseph P. Horrigan
Paige Nues

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1341746

4,062 views
4 citations

Original Research

Published on 22 Jan 2024

Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals

in Experimental Pharmacology and Drug Discovery

Maja Stojković
Zoran Todorović
Dragana Protić
Strahinja Stevanovic
Dragana Medić
Claude L. Charvet
Elise Courtot
Djordje S. Marjanović
Jelena Nedeljković Trailović
Saša M. Trailović

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1326779

1,417 views
1 citation

Original Research

Published on 19 Jan 2024

Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems

in Experimental Pharmacology and Drug Discovery

Chunyan Deng
Chunfeng Lu
Kexin Wang
Mengyuan Chang
Yuntian Shen
Xiaoming Yang
Hualin Sun
Xinlei Yao
Chunjian Qiu
Feng Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1344276

4,348 views
6 citations

Review

Published on 17 Jan 2024

Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes

in Experimental Pharmacology and Drug Discovery

Emily G. Hoffman
Ninoschka C. D’Souza
Richard T. Liggins
Michael C. Riddell

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1295639

2,508 views
3 citations

Original Research

Published on 15 Jan 2024

Structure of human GPR119-Gs complex binding APD597 and characterization of GPR119 binding agonists

in Experimental Pharmacology and Drug Discovery

Ruixue Li
Yuxia Qian
Jiening Wang
Zhen Han
Sheng Ye
Shan Wu
Anna Qiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1310231

1,485 views
1 citation

Editorial

Published on 12 Jan 2024

Editorial: Purinergic signalling in the central nervous system and its pharmacological importance in neurological and psychiatric illnesses

in Experimental Pharmacology and Drug Discovery

Yong Tang
Patrizia Rubini
Beata Sperlagh
Henning Ulrich

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1355286

765 views

Original Research

Published on 11 Jan 2024

Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase

in Experimental Pharmacology and Drug Discovery

Mohd Rehan
Firoz Ahmed
Mohammad Imran Khan
Hifzur Rahman Ansari
Shazi Shakil
Moustafa E. El-Araby
Salman Hosawi
Mohammad Saleem

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1231671

2,150 views
2 citations

Original Research

Published on 11 Jan 2024

Mechanistic insights into the ameliorative effects of hypoxia-induced myocardial injury by Corydalis yanhusuo total alkaloids: based on network pharmacology and experiment verification

in Experimental Pharmacology and Drug Discovery

Jiaying Qi
Haoying Li
Yakun Yang
Xiaoqi Sun
Jianxin Wang
Xue Han
Xi Chu
Zhenqing Sun
Li Chu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1275558

1,454 views
1 citation

Original Research

Published on 11 Jan 2024

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors

in Experimental Pharmacology and Drug Discovery

Rachel H. Clare
Charlotte A. Dawson
Adam Westhorpe
Laura-Oana Albulescu
Christopher M. Woodley
Nada Mosallam
Daniel J. W. Chong
Jeroen Kool
Neil G. Berry
Paul M. O’Neill

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1328950

3,101 views
5 citations

Original Research

Published on 11 Jan 2024

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

in Experimental Pharmacology and Drug Discovery

Laura-Oana Albulescu
Adam Westhorpe
Rachel H. Clare
Christopher M. Woodley
Nivya James
Jeroen Kool
Neil G. Berry
Paul M. O’Neill
Nicholas R. Casewell

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1331224

1,886 views
3 citations

Original Research

Published on 10 Jan 2024

Machine learning-based prediction of composite risk of cardiovascular events in patients with stable angina pectoris combined with coronary heart disease: development and validation of a clinical prediction model for Chinese patients

in Experimental Pharmacology and Drug Discovery

Zihan Wang
Ziyi Sun
Linghua Yu
Zhitian Wang
Lin Li
Xiaoyan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1334439

2,148 views
2 citations

Original Research

Published on 10 Jan 2024

Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations

in Experimental Pharmacology and Drug Discovery

Muhammad Suleman
Tanveer Ahmad
Khadim shah
Norah A. Albekairi
Abdulrahman Alshammari
Abbas Khan
Dong-Qing Wei
Hadi M. Yassine
Sergio Crovella

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1328308

4,799 views
2 citations

Original Research

Published on 08 Jan 2024

Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins

in Experimental Pharmacology and Drug Discovery

Daniel J. Watson
Lizahn Laing
Jacobus P. Petzer
Ho Ning Wong
Christopher J. Parkinson
Lubbe Wiesner
Richard K. Haynes

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1308400

1,423 views

Review

Published on 08 Jan 2024

An updated review of experimental rodent models of pulmonary hypertension and left heart disease

in Experimental Pharmacology and Drug Discovery

Magdalena Jasińska-Stroschein

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1308095

3,272 views

Original Research

Published on 05 Jan 2024

A personalized prediction model for urinary tract infections in type 2 diabetes mellitus using machine learning

in Experimental Pharmacology and Drug Discovery

Yu Xiong
Yu-Meng Liu
Jia-Qiang Hu
Bao-Qiang Zhu
Yuan-Kui Wei
Yan Yang
Xing-Wei Wu
En-Wu Long

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1259596

2,444 views
1 citation

Navigation group

Articles

Dual inhibition of MEK and PI3Kβ/δ–a potential therapeutic strategy in PTEN-wild-type docetaxel-resistant metastatic prostate cancer

Development of trofinetide for the treatment of Rett syndrome: from bench to bedside

Pharmacological effects of monoterpene carveol on the neuromuscular system of nematodes and mammals

Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems

Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes

Structure of human GPR119-Gs complex binding APD597 and characterization of GPR119 binding agonists

Editorial: Purinergic signalling in the central nervous system and its pharmacological importance in neurological and psychiatric illnesses

Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase

Mechanistic insights into the ameliorative effects of hypoxia-induced myocardial injury by Corydalis yanhusuo total alkaloids: based on network pharmacology and experiment verification

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

Machine learning-based prediction of composite risk of cardiovascular events in patients with stable angina pectoris combined with coronary heart disease: development and validation of a clinical prediction model for Chinese patients

Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations

Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins

An updated review of experimental rodent models of pulmonary hypertension and left heart disease

A personalized prediction model for urinary tract infections in type 2 diabetes mellitus using machine learning