Brief Research Report

Published on 20 Mar 2024

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

in Experimental Pharmacology and Drug Discovery

Elena Puris
Liudmila Saveleva
Seppo Auriola
Mikko Gynther
Katja M. Kanninen
Gert Fricker

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1365051

1,354 views

Original Research

Published on 19 Mar 2024

Unraveling DDIT4 in the VDR-mTOR pathway: a novel target for drug discovery in diabetic kidney disease

in Experimental Pharmacology and Drug Discovery

Hai-tao Lu
Yuan-yuan Jiao
Tian-yu Yu
Jing-xuan Shi
Jing-wei Tian
Gu-ming Zou
Lin Liu
Li Zhuo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1344113

1,443 views
2 citations

Original Research

Published on 19 Mar 2024

Design, synthesis, and evaluation of the novel ozagrel–paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent

in Experimental Pharmacology and Drug Discovery

Chijing Zuo
Fulong Yan
Jie Wang
Yulong Zhu
Wenhui Luo
Yan Liu
Wanhui Liang
Weidong Yu
Jingwei Zhang
Daiyin Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1362857

1,143 views
1 citation

Original Research

Published on 14 Mar 2024

In-depth LC-MS and in-vitro studies of a triterpenoid saponin capilliposide-A metabolism modulation in gut microbiota of mice

in Experimental Pharmacology and Drug Discovery

Huan Zhao
Xueli Hu
Shenghong Guan
Jinhong Cai
Xiaohan Li
Jiaxi Fang
Bo Lin
Wei Zhu
Jingkui Tian
Juan Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1361643

1,564 views
1 citation

Review

Published on 13 Mar 2024

Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides

in Experimental Pharmacology and Drug Discovery

Yana K. Reshetnyak
Oleg A. Andreev
Donald M. Engelman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1355893

2,494 views
2 citations

Original Research

Published on 12 Mar 2024

Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae

in Experimental Pharmacology and Drug Discovery

Wesam H. Abdulaal
Nabil A. Alhakamy
Amer H. Asseri
Mohamed F. Radwan
Tarek S. Ibrahim
Solomon Z. Okbazghi
Hisham A. Abbas
Basem Mansour
Aly A. Shoun
Wael A. H. Hegazy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1366459

1,732 views
2 citations

Original Research

Published on 11 Mar 2024

Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism

in Experimental Pharmacology and Drug Discovery

Chengjie Shu
Ling Ge
Zhuohang Li
Bin Chen
Shengliang Liao
Lu Lu
Qinlin Wu
Xinyi Jiang
Yuhan An
Zongde Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378434

2,476 views
5 citations

Review

Published on 11 Mar 2024

Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis

in Experimental Pharmacology and Drug Discovery

Chou-Yi Hsu
Sadegh Rajabi
Maryam Hamzeloo-Moghadam
Abhinav Kumar
Marc Maresca
Pallavi Ghildiyal

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1371002

1,949 views
4 citations

Original Research

Published on 07 Mar 2024

Total phenolic contents, cytotoxic, free radicals, porcine pancreatic α-amylase, and lipase suppressant activities of Artemisia dracunculus plant from Palestine

in Experimental Pharmacology and Drug Discovery

Nidal Jaradat
Majdi Dwikat
Johnny Amer
Mustafa Ghanim
Mohammed Hawash
Fatima Hussein
Linda Issa
Salsabeel Ishtawe
Shahd Salah
Sara Nasser

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1351743

1,447 views
4 citations

Original Research

Published on 07 Mar 2024

Real-world effectiveness of GLP-1 receptor agonist-based treatment strategies on “time in range” in patients with type 2 diabetes

in Experimental Pharmacology and Drug Discovery

Yongru Chen
Jingxian Chen
Shuo Zhang
Dan Zhu
Feiying Deng
Rui Zuo
Yufei Hu
Yue Zhao
Yale Duan
Benwei Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1370594

2,316 views

Review

Published on 06 Mar 2024

Breaking genetic shackles: The advance of base editing in genetic disorder treatment

in Experimental Pharmacology and Drug Discovery

Fang Xu
Caiyan Zheng
Weihui Xu
Shiyao Zhang
Shanshan Liu
Xiaopeng Chen
Kai Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364135

3,895 views
3 citations

Original Research

Published on 06 Mar 2024

Machine learning-based prediction of sertraline concentration in patients with depression through therapeutic drug monitoring

in Experimental Pharmacology and Drug Discovery

Ran Fu
Xin Hao
Jing Yu
Donghan Wang
Jinyuan Zhang
Ze Yu
Fei Gao
Chunhua Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1289673

1,500 views
2 citations

Original Research

Published on 05 Mar 2024

Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression

in Experimental Pharmacology and Drug Discovery

Nem Kumar Jain
Mukul Tailang
Balakumar Chandrasekaran
Nasha’t Khazaleh
Neelaveni Thangavel
Hafiz A. Makeen
Mohammed Albratty
Asim Najmi
Hassan Ahmad Alhazmi
Khalid Zoghebi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1290398

4,133 views
4 citations

Original Research

Published on 01 Mar 2024

Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors

in Experimental Pharmacology and Drug Discovery

Anna Moshnikova
Michael DuPont
Marissa Iraca
Craig Klumpp
Hannah Visca
Dana Allababidi
Phoebe Pelzer
Donald M. Engelman
Oleg A. Andreev
Yana K. Reshetnyak

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1346756

1,502 views
1 citation

Original Research

Published on 01 Mar 2024

Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

in Experimental Pharmacology and Drug Discovery

Anne-Sophie Rebstock
Mareike Wiedmann
Beatrix Stelte-Ludwig
Harvey Wong
Amy J. Johnson
Raquel Izumi
Ahmed Hamdy
Hans-Georg Lerchen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1358393

3,147 views

Review

Published on 29 Feb 2024

Orphan G protein-coupled receptors: the ongoing search for a home

in Experimental Pharmacology and Drug Discovery

Amie Jobe
Ranjit Vijayan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1349097

5,471 views
6 citations

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Articles

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease

Unraveling DDIT4 in the VDR-mTOR pathway: a novel target for drug discovery in diabetic kidney disease

Design, synthesis, and evaluation of the novel ozagrel–paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent

In-depth LC-MS and in-vitro studies of a triterpenoid saponin capilliposide-A metabolism modulation in gut microbiota of mice

Aiming the magic bullet: targeted delivery of imaging and therapeutic agents to solid tumors by pHLIP peptides

Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae

Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism

Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis

Total phenolic contents, cytotoxic, free radicals, porcine pancreatic α-amylase, and lipase suppressant activities of Artemisia dracunculus plant from Palestine

Real-world effectiveness of GLP-1 receptor agonist-based treatment strategies on “time in range” in patients with type 2 diabetes

Breaking genetic shackles: The advance of base editing in genetic disorder treatment

Machine learning-based prediction of sertraline concentration in patients with depression through therapeutic drug monitoring

Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression

Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors

Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment

Orphan G protein-coupled receptors: the ongoing search for a home