Original Research

Published on 11 Nov 2024

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

in Experimental Pharmacology and Drug Discovery

Gaetano Marverti
Maria Gaetana Moschella
Alice Belardo
Michele Lamesta
Giada Mercanile
Lorenzo Tagliazucchi
Daniele Aiello
Alberto Venturelli
Davide Illuminati
Remo Guerrini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1477318

212 views

Original Research

Published on 11 Nov 2024

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

in Experimental Pharmacology and Drug Discovery

Bandar Aldhubiab
Rashed M. Almuqbil
Tamer M. Shehata
Wafaa E. Soliman
Heba S. Elsewedy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1468374

152 views

Original Research

Published on 06 Nov 2024

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

in Experimental Pharmacology and Drug Discovery

Moyad Shahwan
Mohd Shahnawaz Khan
Azna Zuberi
Nojood Altwaijry
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459822

219 views

Mini Review

Published on 06 Nov 2024

Recent advances in extracellular matrix manipulation for kidney organoid research

in Experimental Pharmacology and Drug Discovery

Ren Wang
Yufei Sui
Qiuyan Liu
Yucui Xiong
Shanshan Li
Wu Guo
Yiwei Xu
Sheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1472361

143 views

Original Research

Published on 06 Nov 2024

Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes

in Experimental Pharmacology and Drug Discovery

Qi Shen
Yufan Yuan
Zelin Li
Ying Ling
Jian Wang
Mingjing Gao
Peng Wang
Mengli Li
Lizhong Lai
Jinlan Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1502354

172 views

Original Research

Published on 06 Nov 2024

Yigu decoction regulates plasma miRNA in postmenopausal osteoporosis patients: a randomized controlled trial

in Experimental Pharmacology and Drug Discovery

Haifeng Chen
Ruikun Zhang
Guijin Li
Kun Yan
Ziqi Wu
Yang Zhang
Zhineng Chen
Xinmiao Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1460906

130 views

Original Research

Published on 05 Nov 2024

Exploring the mechanism of sesamin for the treatment of PM2.5-induced cardiomyocyte damage based on transcriptomics, network pharmacology and experimental verification

in Experimental Pharmacology and Drug Discovery

Yadong Zhang
Rui Wen
Jingyi Ren
Fan Zhang
Huanting Pei
Jinshi Zuo
Yuxia Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486563

203 views

Systematic Review

Accepted on 04 Nov 2024

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: A systematic review and meta-analysis

in Experimental Pharmacology and Drug Discovery

Jinkun Li
Huangxudong Huangxudong
Yifeng Yuan
Haixin Zhang
Zhou Hang
Wei Xiong
Yuyi Li
Zechen Zhang
Fengqing Qie
Kang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505926

Review

Accepted on 04 Nov 2024

Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis

in Experimental Pharmacology and Drug Discovery

Rou Deng
Xiayu Cui
Runze Zhang
Changya Liu
Jielian Luo
Liang Liu
Wen Zhang
Bangjiang Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452276

Review

Published on 01 Nov 2024

Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies

in Experimental Pharmacology and Drug Discovery

Yuxun Wei
Hong Li
Yue Li
Yue Zeng
Tian Quan
Yanen Leng
En Chang
Yingtao Bai
Yuan Bian
Yi Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496661

293 views

Systematic Review

Published on 01 Nov 2024

Efficacy of different traditional Chinese medicine decoctions in the treatment of ischemic stroke: a network meta-analysis

in Experimental Pharmacology and Drug Discovery

Baicheng Ning
Xiaoting Zhu
Xiaodong Wu
Weiyao Zhu
Runze Wang
Chang Qi
Mingquan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486458

224 views

Original Research

Published on 01 Nov 2024

D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis

in Experimental Pharmacology and Drug Discovery

Yuqing Lu
Yongjian Xiong
Shuangshuang Zhang
Boya Wang
Yuntao Feng
Zhuonan Pu
Kun Wei
Jun Chen
Dapeng Chen
Peng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1454713

245 views

Original Research

Accepted on 31 Oct 2024

Exploring Somatic Mutations in BRAF, KRAS, and NRAS as Therapeutic Targets in Saudi Colorectal Cancer Patients through Massive Parallel Sequencing and Variant Classification

in Experimental Pharmacology and Drug Discovery

Thamer Abdulhamid Aljuhani
Shaik Noor Ahmad
Rahaf Talal Alqawas
Rana Y Bokhary
Mahmoud Almutadares
Hadiah Bassam Al Mahdi
Nuha Al-Rayes
Ashraf Abdulrahman El-Harouni
Ramu Elango
Zuhier Ahmad Awan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498295

Original Research

Accepted on 31 Oct 2024

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

in Experimental Pharmacology and Drug Discovery

Chenxi Wang
Xin Zhao
Jingjing Jiang
Mengqi Jia
Wenqing Shi
Zhenghua Wu
Shiyu Feng
Guorong Fan
Yuefen Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1481091

Original Research

Accepted on 31 Oct 2024

Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound

in Experimental Pharmacology and Drug Discovery

Ghobad Mohammadi
Mosayeb Safari
Masoud Karimi
Amin Iranpanah
Mohammad Hosein Farzaei
Sajad Fakhri
Javier Echeverria

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1474981

Original Research

Published on 31 Oct 2024

Protective effect of baicalin on oxidative stress injury in retinal ganglion cells through the JAK/STAT signaling pathway in vitro and in vivo

in Experimental Pharmacology and Drug Discovery

Huan Yu
Dan Zhou
Wei Wang
Qingxia Wang
Min Li
Xiaoyun Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443472

157 views

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Articles

Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation

Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy

Structure-guided drug repurposing identifies aristospan as a potential inhibitor of β-lactamase: insights from virtual screening and molecular dynamics simulations

Recent advances in extracellular matrix manipulation for kidney organoid research

Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes

Yigu decoction regulates plasma miRNA in postmenopausal osteoporosis patients: a randomized controlled trial

Exploring the mechanism of sesamin for the treatment of PM2.5-induced cardiomyocyte damage based on transcriptomics, network pharmacology and experimental verification

Efficacy and safety of Epimedium total flavonoids for primary osteoporosis: A systematic review and meta-analysis

Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsis

Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies

Efficacy of different traditional Chinese medicine decoctions in the treatment of ischemic stroke: a network meta-analysis

D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis

Exploring Somatic Mutations in BRAF, KRAS, and NRAS as Therapeutic Targets in Saudi Colorectal Cancer Patients through Massive Parallel Sequencing and Variant Classification

Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

Preparation and characterization of Pistacia atlantica oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound

Protective effect of baicalin on oxidative stress injury in retinal ganglion cells through the JAK/STAT signaling pathway in vitro and in vivo