Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 14 Apr 2025

DTGHAT: Multi-molecule heterogeneous graph Transformer based on multi-molecule graph for drug-target identification

in Experimental Pharmacology and Drug Discovery

Xinchen Jiang
Lu Wen
Wenshui Li
Que Deng
Ming Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1596216

Original Research

Published on 14 Apr 2025

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
XuZai Deng
Shuge Wang
Tao Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

309 views

Original Research

Accepted on 11 Apr 2025

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells

in Experimental Pharmacology and Drug Discovery

Ye Yang
Jieyun Zhou
Qiaoying Lv
Qicheng Ni
Baichun Hu
Yulong Wang
Shuning Qu
Guoting Li
Wenjie Yang
Ruihua Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573032

118 views

Original Research

Accepted on 11 Apr 2025

Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes

in Experimental Pharmacology and Drug Discovery

Jiangming Zhong
Ling Liang
Nan Zhao
Jing Wang
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562244

160 views

Original Research

Accepted on 11 Apr 2025

Prognostic Significance and Multivariate Modeling of COL4A Family Genes and HMGA2 in Glioma

in Experimental Pharmacology and Drug Discovery

Aijun Lu
Jiankun Zang
Na Tan
Liping Wei
Ying Liang
Zefeng Tan
Anding Xu
Dan Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591932

Original Research

Accepted on 11 Apr 2025

Integrating ensemble machine learning and multi-omics approaches to identify Dp44mT as a novel anti-Candida albicans agent targeting cellular iron homeostasis

in Experimental Pharmacology and Drug Discovery

Xiaowei Chai
Yuanying Jiang
Hui Lu
Xin Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574990

149 views

Original Research

Published on 11 Apr 2025

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

in Experimental Pharmacology and Drug Discovery

Bin Liao
Pan Wang
Sheng Gong
Lu Zhao
Jie Liu
Nan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575332

311 views

Original Research

Accepted on 10 Apr 2025

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering Danazol versus Berotralstat

in Experimental Pharmacology and Drug Discovery

Mauro Cancian
Andrea Zanichelli
Dario Cattaneo
Antonio Gidaro
Riccardo Senter
Francesco Arcoleo
Pietro Andrea Accardo
Donatella Bignardi
Paolo Borrelli
Caterina Colangelo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550133

200 views

Review

Published on 09 Apr 2025

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

in Experimental Pharmacology and Drug Discovery

Xiaobei Lu
Yapeng Sun
Zhaoyi Zhang
Zhigang Sun
Shaohui Wang
Erping Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573684

219 views

Original Research

Published on 09 Apr 2025

Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

in Experimental Pharmacology and Drug Discovery

Kai Gong
Shuang Zhou
Li Xiao
Mengzhen Xu
Yuhe Zhou
Kaihui Lu
Xin Yu
Jiang Zhu
Chuanguo Liu
Qingjun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588375

267 views

Original Research

Published on 09 Apr 2025

Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats

in Experimental Pharmacology and Drug Discovery

Yang Bai
Rui Wang
Can Jin
Lili Wang
Yun Tang
Han Wang
Kan Ding
Shanjun Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1499420

199 views

Original Research

Published on 09 Apr 2025

Discovery of CMNPD31124 as a novel marine-derived PKMYT1 inhibitor for pancreatic ductal adenocarcinoma therapy: computational and biological insights

in Experimental Pharmacology and Drug Discovery

Chaojie Huang
Ting Wang
Rui Chen
Yunyun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569765

307 views

Original Research

Published on 09 Apr 2025

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay

in Experimental Pharmacology and Drug Discovery

Leire Borrega-Roman
Bradley L. Hoare
Miroslav Kosar
Roman C. Sarott
Kacper J. Patej
Jara Bouma
Morgan Scott-Dennis
Eline J. Koers
Thais Gazzi
Leonard Mach

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469986

852 views

Original Research

Accepted on 08 Apr 2025

Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity

in Experimental Pharmacology and Drug Discovery

Lihua Yang
Hang Zhai
Tingting Tian
Botong Liu
Xianpu Ni
Huanzhang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575840

Original Research

Accepted on 08 Apr 2025

Wuling capsule alleviates hyperuricaemia and protects UA-injured HK-2 cells by regulating uric acid transporter proteins

in Experimental Pharmacology and Drug Discovery

Nan Li
Hongna Liu
Zhongxing Song
Rui Zhou
Zhishu Tang
Hongbo Xu
Xinbo Shi
Yan-Ru Liu
Jian Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563676

Original Research

Accepted on 08 Apr 2025

LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis

in Experimental Pharmacology and Drug Discovery

Yihan Liu
Long Cui
Runze Li
Dan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569644