Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 07 Jan 2025

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-breast cancer compound combinations from Prunella vulgaris L.-Taraxacum mongolicum Hand.-Mazz. herb pair

in Experimental Pharmacology and Drug Discovery

Chunlai Feng
Jiaxi Cheng
Mengqiu Sun
Chunxue Qiao
Qiuqi Feng
Naying Fang
Yingying Ge
Mengjie Rui

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1522787

898 views
1 citation

Original Research

Published on 06 Jan 2025

Efficacy of the Bushen Jianpi Huoxue Formula on Beclin-1/Bcl-2-mediated autophagy and apoptosis in osteoblasts

in Experimental Pharmacology and Drug Discovery

Yanping Lin
Rui Zhao
Jiachun Huang
Tongying Chen
Haolin Yang
Haiwei Guo
Lei Wan
Zhihai Zhang
Ying Li
Genfu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513298

1,020 views

Correction

Published on 06 Jan 2025

Corrigendum: Ginkgolide C alleviates myocardial ischemia/reperfusion-induced inflammatory injury via inhibition of CD40-NF-κB pathway

in Experimental Pharmacology and Drug Discovery

Rui Zhang
Dan Han
Zhenyu Li
Chengwu Shen
Yahui Zhang
Jun Li
Genquan Yan
Shasha Li
Bo Hu
Jiangbing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492520

514 views

Original Research

Published on 06 Jan 2025

Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy

in Experimental Pharmacology and Drug Discovery

Sumin Sun
Haili Hu
Feiyu Li
Sheng Huan
Long Chen
Jiahui Chen
Peihua Sun
Xiaoqing Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1503490

853 views

Review

Published on 06 Jan 2025

An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway

in Experimental Pharmacology and Drug Discovery

Pratibha Pandey
Sorabh Lakhanpal
Danish Mahmood
Han Na Kang
Byunggyu Kim
Sojin Kang
Jinwon Choi
Min Choi
Shivam Pandey
Mahakshit Bhat

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1513422

1,662 views

Original Research

Published on 06 Jan 2025

Biological activities of Usnea lethariiformis lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites

in Experimental Pharmacology and Drug Discovery

Mauricio Piñeiro
Sofía Manrique
Jessica Gómez
Juan Manuel Rodriguez
Patricia Barrera
Duilio Caballero
Miguel A. Sosa
Gabriel Vargas-Arana
Alejandro Tapia
Beatriz Lima

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1508835

1,281 views
1 citation

Original Research

Published on 06 Jan 2025

A study to assess the pharmacological agent potential of gold nanoparticles and their effects on human cancer cells and hospital pathogens using in vitro methods

in Experimental Pharmacology and Drug Discovery

Ayşe Baran

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498734

381 views

Review

Published on 06 Jan 2025

Plant and marine-derived natural products: sustainable pathways for future drug discovery and therapeutic development

in Experimental Pharmacology and Drug Discovery

Muhammad Ahmad
Maleha Tahir
Zibin Hong
Muhammad Anjum Zia
Hamza Rafeeq
Muhammad Shaheez Ahmad
Saif ur Rehman
Junming Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1497668

2,631 views

Original Research

Published on 03 Jan 2025

Protein-ligand binding affinity prediction using multi-instance learning with docking structures

in Experimental Pharmacology and Drug Discovery

Hyojin Kim
Heesung Shim
Aditya Ranganath
Stewart He
Garrett Stevenson
Jonathan E. Allen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518875

1,477 views

Original Research

Published on 03 Jan 2025

Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats

in Experimental Pharmacology and Drug Discovery

Izzet Emir
Seval Bulut
Bahadır Suleyman
Renad Mammadov
Nurinisa Yucel
Betul Cicek
Gulce Naz Yazici
Durdu Altuner
Murat Gunay
Halis Suleyman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1503032

756 views

Original Research

Published on 03 Jan 2025

Modulation of gut microbiota, up-regulation of ZO-1, and promotion of metabolism as therapeutic mechanisms of indole-3-carbinol against obesity in mice

in Experimental Pharmacology and Drug Discovery

XuWen Mao
Guliruoyi Paerhati
Yuche Wu
Lu Feng Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499142

1,162 views
1 citation

Review

Published on 24 Dec 2024

Large language models facilitating modern molecular biology and novel drug development

in Experimental Pharmacology and Drug Discovery

Xiao-huan Liu
Zhen-hua Lu
Tao Wang
Fei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1458739

1,836 views

Review

Published on 23 Dec 2024

Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target

in Experimental Pharmacology and Drug Discovery

Qian-Yun Ye
Yan Cui
Hao-Yu Wang
Ling-Yu Li
Jian-Bing Chen
Xiao-Feng Zhu
Zhi-Jian Xue
Rong-Hua Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1516125

1,117 views

Original Research

Published on 23 Dec 2024

Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer

in Experimental Pharmacology and Drug Discovery

Fengyu Wang
Xiaojing Zou
Chunyang Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1529631

752 views

Review

Published on 20 Dec 2024

β-blockers and metabolic modulation: unraveling the complex interplay with glucose metabolism, inflammation and oxidative stress

in Experimental Pharmacology and Drug Discovery

Szymon Drygała
Michał Radzikowski
Mateusz Maciejczyk

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1489657

2,229 views
1 citation

Original Research

Published on 20 Dec 2024

The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo

in Experimental Pharmacology and Drug Discovery

Xirui Xia
Xuan Ji
Yaxi Li
Yubo Wang
Yue Zhao
Wenxiang Wang
Huanzhong Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491223

916 views