Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 20 Jan 2025

4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies

in Experimental Pharmacology and Drug Discovery

Ashanul Haque
Khalaf M. Alenezi
Mohd. Saeed Maulana Abdul Rasheed
Md. Ataur Rahman
Saleha Anwar
Shahzaib Ahamad
Dinesh Gupta

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1517504

913 views
1 citation

Original Research

Published on 20 Jan 2025

Nicotine’s impact on platelet function: insights into hemostasis mechanisms

in Experimental Pharmacology and Drug Discovery

Xiayu Wu
Yongjun Liu
Changhao Zou
Fuqin He
Fang Guo
Sijia Liu
Yi Fan
Xuedong Zhu
Qianyi Zhou
Dan Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1512142

1,098 views
1 citation

Review

Published on 20 Jan 2025

Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus

in Experimental Pharmacology and Drug Discovery

Xu He
Wei Zhao
PeiHang Li
YinJiang Zhang
GuoHua Li
HongYu Su
BiNan Lu
ZongRan Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1483792

1,906 views

Original Research

Published on 17 Jan 2025

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

in Experimental Pharmacology and Drug Discovery

Monika Jürgenson
Keerthana Chithanathan
Aivar Orav
Külli Jaako
Janeli Viil
Mithu Guha
Kalev Kask
Alexander Zharkovsky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505729

2,074 views

Original Research

Published on 15 Jan 2025

Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study

in Experimental Pharmacology and Drug Discovery

Yuan Liu
Jianjie Ouyang
Cuicui Zhang
Pingping Niu
Baoling Shang
Gengzhen Yao
Yongyong Shi
Xu Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1529167

1,401 views

Original Research

Published on 15 Jan 2025

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

in Experimental Pharmacology and Drug Discovery

Wenxin Zhang
Hongbo Teng
Tianyi Zhao
Roberts I. Eglitis
Xv Wang
Zhengxuan Yu
Shurong Qu
Haijing Wang
Yaru Zhao
Bowen Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518810

1,124 views

Systematic Review

Published on 15 Jan 2025

Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies

in Experimental Pharmacology and Drug Discovery

Feng Zhang
Tao Li
Junli Wan
Lu Wang
Wenmei Guo
Yue Hu
Hao Wang
Wei Bian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1521188

1,393 views

Original Research

Published on 14 Jan 2025

Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies

in Experimental Pharmacology and Drug Discovery

Xiangjun Wang
Xiaowen Xia
Xianliang Song
Yi Zhou
Mingyu Ma
Yashuang Ren
Xitai Chen
Zenghui Xia
Yinghui Guo
Chunhong Song

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1525753

1,642 views
1 citation

Original Research

Published on 09 Jan 2025

Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation

in Experimental Pharmacology and Drug Discovery

Michaela Prchal-Murphy
Julia Zehenter
Marlene Fischer
Anita Pirabe
Madeleine Themanns
Behnaz Afrashteh
Eva Maria Putz
Karoline Kollmann
José Basílio
Manuel Salzmann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1444311

1,353 views

Original Research

Published on 09 Jan 2025

Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells

in Experimental Pharmacology and Drug Discovery

Qi Zhao
Yan Zhang
Jieyu Liu
Peipei Chen
Annabeth Onga
Namki Cho
Ri Cui
Chenguo Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1532695

1,040 views

Original Research

Published on 09 Jan 2025

Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study

in Experimental Pharmacology and Drug Discovery

Xiaoyan Wang
Pengcheng Yu
Wei Jia
Bingbing Wan
Zhougui Ling
Yangyang Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1539120

843 views

Original Research

Published on 08 Jan 2025

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

in Experimental Pharmacology and Drug Discovery

Weifeng Shan
Shuying Gao
Mengting Ai
Haiyan Lan
Gongchen Duan
Xiaoli Dong
Qiaomin Xu
Yini Wu
Jimin Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1427755

1,211 views

Original Research

Published on 08 Jan 2025

ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway

in Experimental Pharmacology and Drug Discovery

Jiali Hu
Jing Cao
Shanshan Huang
Yang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1536478

895 views

Original Research

Published on 08 Jan 2025

Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway

in Experimental Pharmacology and Drug Discovery

Yumei Rong
Minghui Zhu
Nan Wang
Feiyu Zhang
Tianjun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1539363

751 views

Original Research

Published on 07 Jan 2025

Therapeutic effects of composite probiotics derived from fermented camel milk on metabolic dysregulation and intestinal barrier integrity in type 2 diabetes rats

in Experimental Pharmacology and Drug Discovery

Tabusi Manaer
Jialehasibieke Sailike
Xin Sun
Baheban Yeerjiang
Xinhua Nabi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1520158

1,266 views

Review

Published on 07 Jan 2025

Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry

in Experimental Pharmacology and Drug Discovery

Estéfani Alves Asevedo
Livia Ramos Santiago
Hyo Jeong Kim
Rony Abdi Syahputra
Moon Nyeo Park
Rosy Iara Maciel Azambuja Ribeiro
Bonglee Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1514573

1,399 views