Original Research

Published on 30 Jul 2024

Naringin and temozolomide combination suppressed the growth of glioblastoma cells by promoting cell apoptosis: network pharmacology, in-vitro assays and metabolomics based study

in Experimental Pharmacology and Drug Discovery

Priya Bisht
Surendra Rajit Prasad
Khushboo Choudhary
Ruchi Pandey
Dande Aishwarya
Vulli Aravind
Peraman Ramalingam
Ravichandiran Velayutham
Nitesh Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431085

2,078 views

Original Research

Published on 30 Jul 2024

Pharmacokinetics and tissue distribution of LN002, a new compound alternative oxidase inhibitor against Cryptosporidium in rats

in Experimental Pharmacology and Drug Discovery

Minglang Ma
Yongxiang Zhang
Yanjun Fang
Yixing Lu
Huiguo Huang
Zhenling Zeng
Dongping Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1413872

650 views

Editorial

Published on 30 Jul 2024

Editorial: The culprit behind some diseases: overexpression/hyperactivity of G6PD

in Experimental Pharmacology and Drug Discovery

Muhammet Karaman
N. Nuray Ulusu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459741

584 views

Original Research

Published on 29 Jul 2024

Machine learning-based prediction model for the efficacy and safety of statins

in Experimental Pharmacology and Drug Discovery

Yu Xiong
Xiaoyang Liu
Qing Wang
Li Zhao
Xudong Kong
Chunhe Da
Zuohuan Meng
Leilei Qu
Qinfang Xia
Lihong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1334929

1,168 views

Original Research

Published on 29 Jul 2024

Soloxolone para-methylanilide effectively suppresses aggressive phenotype of glioblastoma cells including TGF-β1-induced glial-mesenchymal transition in vitro and inhibits growth of U87 glioblastoma xenografts in mice

in Experimental Pharmacology and Drug Discovery

Kirill V. Odarenko
Aleksandra V. Sen’kova
Oksana V. Salomatina
Oleg V. Markov
Nariman F. Salakhutdinov
Marina A. Zenkova
Andrey V. Markov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428924

1,508 views
1 citation

Original Research

Published on 29 Jul 2024

Melatonin supplementation counteracts fiber loss in knee ligaments of diabetes-induced rats

in Experimental Pharmacology and Drug Discovery

Olga Adamska
Artur Wnuk
Agnieszka Kamińska
Małgorzata Poniatowska
Bartosz Maciąg
Maciej Kamiński
Artur Stolarczyk
Maima Matin
Atanas G. Atanasov
Marcin Łapiński

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1399719

1,305 views

Original Research

Published on 29 Jul 2024

Potential mechanism of Luoshi Neiyi prescription in endometriosis based on serum pharmacochemistry and network pharmacology

in Experimental Pharmacology and Drug Discovery

Lizheng Wu
Shuhong Lin
Yongjun Hu
Shangwen Jing
Bowen Sun
Xiaoxin Chen
Jinjin Jia
Cheng Zeng
Fangli Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1395160

1,595 views

Original Research

Published on 26 Jul 2024

LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway

in Experimental Pharmacology and Drug Discovery

Qian Deng
Yuelan Gao
Yujin Wang
Jiewen Mao
Yulin Yan
Zixian Yang
Yuyu Cong
Yanning Yang
Shanshan Wan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1411513

1,301 views

Original Research

Published on 26 Jul 2024

Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway

in Experimental Pharmacology and Drug Discovery

Congcong Shang
Yunfang Su
Jinlian Ma
Zhonghua Li
Pan Wang
Huifen Ma
Junying Song
Zhenqiang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1434568

1,296 views

Original Research

Published on 26 Jul 2024

Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation

in Experimental Pharmacology and Drug Discovery

So-Hyeon Park
Yunkyung Heo
Il Kwon
Sungwoo Jo
Hyejin Jeon
Yechan Lee
Jieun Kim
Ji Hoe Heo
Wan Namkung

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1430548

816 views

Review

Published on 25 Jul 2024

Current concepts of the crosstalk between lncRNA and E2F1: shedding light on the cancer therapy

in Experimental Pharmacology and Drug Discovery

Peng Huang
Feng Wen
Qiu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432490

1,021 views

General Commentary

Published on 24 Jul 2024

Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration

in Experimental Pharmacology and Drug Discovery

Fabien Beaufils
Patrick Berger

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1432397

461 views

Original Research

Published on 24 Jul 2024

Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation

in Experimental Pharmacology and Drug Discovery

Du Yijie
Zhao Siqi
Huang Ruiyin
Shi YuJing
Meng Hong
Dong Yinmao
Yang Tao
Luo Changyong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1414856

997 views
1 citation

Original Research

Published on 22 Jul 2024

Synthesis, characterization, and mechanistic insights into the enhanced anti-inflammatory activity of baicalin butyl ester via the PI3K-AKT pathway

in Experimental Pharmacology and Drug Discovery

Hongxu Du
Zhangxun Li
Lijuan Su
Zhengke He
Xiaoyan Tan
Fengzhi Hou
Tanjie He
Yu Pan
Shuang Xu
Liting Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1417372

876 views

Original Research

Published on 19 Jul 2024

YinChen WuLing powder attenuates non-alcoholic steatohepatitis through the inhibition of the SHP2/PI3K/NLRP3 pathway

in Experimental Pharmacology and Drug Discovery

Xingxing Yuan
Liuxin Yang
Tinting Gao
Jiawei Gao
Bingyu Wang
Chengxiang Liu
Wei Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423903

1,563 views

Original Research

Published on 19 Jul 2024

In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides

in Experimental Pharmacology and Drug Discovery

Abudukahaer Wubuli
Junwei Chai
Haoqiang Liu
Dilaram Nijat
Jianmin Li
Guoyu Xia
Qi Cao
Saidan Zhang
Weidong Huang
Adila Aipire

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431221

1,126 views
1 citation

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Articles

Naringin and temozolomide combination suppressed the growth of glioblastoma cells by promoting cell apoptosis: network pharmacology, in-vitro assays and metabolomics based study

Pharmacokinetics and tissue distribution of LN002, a new compound alternative oxidase inhibitor against Cryptosporidium in rats

Editorial: The culprit behind some diseases: overexpression/hyperactivity of G6PD

Machine learning-based prediction model for the efficacy and safety of statins

Soloxolone para-methylanilide effectively suppresses aggressive phenotype of glioblastoma cells including TGF-β1-induced glial-mesenchymal transition in vitro and inhibits growth of U87 glioblastoma xenografts in mice

Melatonin supplementation counteracts fiber loss in knee ligaments of diabetes-induced rats

Potential mechanism of Luoshi Neiyi prescription in endometriosis based on serum pharmacochemistry and network pharmacology

LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway

Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR/HIF-1α signaling pathway

Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation

Current concepts of the crosstalk between lncRNA and E2F1: shedding light on the cancer therapy

Commentary: Effect of curcumin nanoparticles on proliferation and migration of mouse airway smooth muscle cells and airway inflammatory infiltration

Mechanisms of Puerariae Lobatae Radix in regulating sebaceous gland secretion: insights from network pharmacology and experimental validation

Synthesis, characterization, and mechanistic insights into the enhanced anti-inflammatory activity of baicalin butyl ester via the PI3K-AKT pathway

YinChen WuLing powder attenuates non-alcoholic steatohepatitis through the inhibition of the SHP2/PI3K/NLRP3 pathway

In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides