Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Editorial

Published on 29 Jan 2025

Editorial: Activation of the cGAS-STING pathway by extra-nuclear DNA and its pharmacognostic modulation in human disease

in Experimental Pharmacology and Drug Discovery

Preston M. McCourt
Charles A. Day
Souren Paul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519429

824 views

Review

Published on 29 Jan 2025

Polymers for the treatment of Alzheimer’s disease

in Experimental Pharmacology and Drug Discovery

Yunfeng Zhu
Haibin Xu
Chaoyan Yu
Wenting Jiang
Xiaowen Hou
Mingyue Ma
Ji Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512941

1,270 views

Review

Published on 28 Jan 2025

A current review on animal models of anti-asthmatic drugs screening

in Experimental Pharmacology and Drug Discovery

Shivam Singh
Sunita Kularia
Shivakshi Shukla
Mithilesh Singh
Manish Kumar
Ashish Kumar Sharma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508460

1,353 views

Original Research

Published on 28 Jan 2025

3D-QSAR, design, molecular docking and dynamics simulation studies of novel 6-hydroxybenzothiazole-2-carboxamides as potentially potent and selective monoamine oxidase B inhibitors

in Experimental Pharmacology and Drug Discovery

Dong Xie
Yongzheng Tian
Li Cao
Penghang Guo
Zhibiao Cai
Jie Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545791

801 views

Original Research

Published on 28 Jan 2025

Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction

in Experimental Pharmacology and Drug Discovery

Yize Sun
Haibin Zhao
Zheyi Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1499418

939 views

Original Research

Published on 28 Jan 2025

Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells

in Experimental Pharmacology and Drug Discovery

Ye Zhu
Junxiu Wei
Xin Yang
Wei Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496393

823 views

Original Research

Published on 27 Jan 2025

A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma

in Experimental Pharmacology and Drug Discovery

Shihao Li
Lina Zhang
Haiyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1532610

835 views

Original Research

Published on 24 Jan 2025

Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head necrosis

in Experimental Pharmacology and Drug Discovery

Manting Liu
Jiexiang Ye
Runtian Wu
Dongqiang Luo
Tao Huang
Dandan Dai
Kexin Wang
Yanping Du
Junwen Ou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506594

1,382 views

Original Research

Published on 24 Jan 2025

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus

in Experimental Pharmacology and Drug Discovery

Fangyu Li
Rui Li
Hongjun Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521416

906 views

Original Research

Published on 23 Jan 2025

hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways

in Experimental Pharmacology and Drug Discovery

Yan Yu
Chengchun Zhu
Xiao Wang
Ying Shi
Yiping Gao
Zhiyi Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545300

1,063 views

Original Research

Published on 23 Jan 2025

Chemical characterization and encapsulation of Ganoderma pfeifferi extract with cytotoxic properties

in Experimental Pharmacology and Drug Discovery

Jan Šťastný
Ángela Morellá-Aucejo
Tomáš Skala
Andrea Bernardos
Petr Maršík
Araceli Lérida-Viso
Jaroslav Matějka
Anna Mascellani Bergo
María Dolores Marcos
Ramón Martínez-Máñez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526502

751 views

Review

Published on 23 Jan 2025

A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms

in Experimental Pharmacology and Drug Discovery

Yuan Yan
Yiyao Wu
Yu Zhao
Yaguang Yang
Guangtao An
Zhidong Liu
Dongli Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513406

1,363 views

Editorial

Published on 21 Jan 2025

Editorial: Methods in experimental pharmacology 2023

in Experimental Pharmacology and Drug Discovery

Somasundaram Arumugam
Amit Khurana
Kala Kumar Bharani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531464

862 views

Original Research

Published on 21 Jan 2025

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

in Experimental Pharmacology and Drug Discovery

Wen Wang
Meiting Wang
Huanbai Wang
Weifeng Xu
Conggang Wang
Jie Pei
Xiaodan Li
Dongting Zhangsun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1466504

853 views

Original Research

Published on 21 Jan 2025

Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments

in Experimental Pharmacology and Drug Discovery

Bowen Yin
Jingyi Ren
Xuanyi Liu
Yadong Zhang
Jinshi Zuo
Rui Wen
Huanting Pei
Miaomiao Lu
Siqi Zhu
Zhenao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524448

1,687 views

Original Research

Published on 20 Jan 2025

α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach

in Experimental Pharmacology and Drug Discovery

Aimin Cai
Dingchao Shen
Qiushuang Xiong
Jie Ding
Yang Ding
Xinlu Lin
Lijia Chen
Qing Yao
Guangyong Lin
Ruijie Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1463673

1,073 views