Original Research

Published on 15 Nov 2024

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

in Experimental Pharmacology and Drug Discovery

Yang Yang
Yuting Wang
Jing Chen
Miao-Miao Niu
Yongbin Wang
Xing Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1491497

Mini Review

Accepted on 14 Nov 2024

Revealing Secrets of Blue Zones

in Experimental Pharmacology and Drug Discovery

Nuray Nuriye Ulusu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428111

Original Research

Published on 14 Nov 2024

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

in Experimental Pharmacology and Drug Discovery

Mohammed Alrouji
Kumar Venkatesan
Mohammed S. Alshammari
Fahad A. Alhumaydhi
Sheeba Shafi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1488585

229 views

Original Research

Accepted on 13 Nov 2024

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

in Experimental Pharmacology and Drug Discovery

Xin Yang
Canhui Hong
Tangfei Guan
ChengGui Zhang
Pei Yun Xiao
Yongshou Yang
Huai Xiao
Zhengchun He

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1429960

Original Research

Accepted on 13 Nov 2024

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation Authors and affiliations

in Experimental Pharmacology and Drug Discovery

Zihao Li
Qing Wei
Fangfang Yang
Chen Ke
Tian Li
Yijun Li
Liqun Li
Zhongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453938

Review

Published on 13 Nov 2024

In-depth analysis of lupeol: delving into the diverse pharmacological profile

in Experimental Pharmacology and Drug Discovery

Aminah Dalimunthe
Mega Carensia Gunawan
Zahirah Dhiya Utari
Muhammad Riza Dinata
Princella Halim
Nathasya Estherina S. Pakpahan
Alex Insandus Sitohang
M. Andriansyah Sukarno
Yuandani
Yahdiana Harahap

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1461478

129 views

Original Research

Published on 13 Nov 2024

Glucocorticoids influence on rat hematological parameters and catalase activity

in Experimental Pharmacology and Drug Discovery

Safija Herenda
Ivana Carev
Denis Haskovic
Sabina Prevljak
Sara Causevic
Edhem Haskovic

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1367350

Review

Published on 13 Nov 2024

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

in Experimental Pharmacology and Drug Discovery

Pedro Gabriel Senger Braga
Janaína da Silva Vieira
Aline Rachel Bezerra Gurgel
Patricia Chakur Brum

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423502

107 views

Original Research

Published on 13 Nov 2024

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

in Experimental Pharmacology and Drug Discovery

Jiandong Wang
Xue Zhang
Yi Wu
Qianfei Wei
Lingshan Yan
Youli Yu
Yanan Guo
Zhengqin Yu
Pan Wang
Xiaonan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1486739

Original Research

Published on 13 Nov 2024

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

in Experimental Pharmacology and Drug Discovery

Juan Chen
Szetuen Ng
Pengchao Xu
Sainan Chen
Shengqiang Li
Xuan Chen
Lihua Xie
Jirong Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505231

Original Research

Published on 12 Nov 2024

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

in Experimental Pharmacology and Drug Discovery

Jie Wen
Lingmao Zhao
Zhuohan Li
Chao Pi
Xianhu Feng
Peng Shi
Hongru Yang
Ligang Chen
Xiaodong Wang
Furong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1464626

122 views

Original Research

Published on 12 Nov 2024

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

in Experimental Pharmacology and Drug Discovery

Dayma Llanes
Robert Rennert
Paul Jänicke
Ibrahim Morgan
Leslie Reguera
Daniel G. Rivera
Manuel G. Ricardo
Ludger A. Wessjohann

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1408091

195 views

Original Research

Accepted on 11 Nov 2024

Cytotoxicity of Natural and Synthetic Cannabinoids and Their Synergistic Antiproliferative Effects with Cisplatin in Human Ovarian Cancer Cells

in Experimental Pharmacology and Drug Discovery

Ying Chen
Huifang Li
Jia Liu
Jie Ni
Qicheng Deng
Haotian He
Panpan Wu
Yinsheng Wan
Navindra P Seeram
Chang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496131

Original Research

Accepted on 11 Nov 2024

Zebrafish-Based Identification of Anti-seizure Compounds from Natural Products

in Experimental Pharmacology and Drug Discovery

Fuyun Tian
Hongyuan Zuo
Zhidan Wu
Shuoshuo Zheng
Meixuan Ping
Xinni Bin
Zhaobing Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499309

Review

Accepted on 11 Nov 2024

Therapeutic implications of traditional Chinese medicine in clinically relevant diseases: Perspectives from microRNA-modulated apoptotic signaling

in Experimental Pharmacology and Drug Discovery

Chunjie Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437019

Review

Accepted on 11 Nov 2024

The role of artificial intelligence in drug screening, drug design, and clinical trials

in Experimental Pharmacology and Drug Discovery

Yuyuan Wu
Lijing Ma
Xinyi Li
Jingpeng Yang
Xinyu Rao
Yiru Hu
Jingyi Xi
Lin Tao
Jianjun Wang
Shuiping Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459954

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Articles

Discovery of novel and highly potent dual-targeting PKMYT1/HDAC2 inhibitors for hepatocellular carcinoma through structure-based virtual screening and biological evaluation

Revealing Secrets of Blue Zones

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

Dexmedetomidine regulates the anti-oxidation and autophagy of adipose-derived stromal cells under H2O2-induced oxidative stress through Nrf2/p62 pathway and improves the retention rate of autologous fat transplantation Authors and affiliations

In-depth analysis of lupeol: delving into the diverse pharmacological profile

Glucocorticoids influence on rat hematological parameters and catalase activity

β-blockers and statins: exploring the potential off-label applications in breast, colorectal, prostate, and lung cancers

Integration of metabolomics and transcriptomics to reveal anti-immunosuppression mechanism of Lycium barbarum polysaccharide

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

Preparation and anti-colon cancer effect of a novel curcumin analogue (CA8): in vivo and in vitro evaluation

Development of bombesin-tubulysin conjugates using multicomponent chemistry to functionalize both the payload and the homing peptide

Cytotoxicity of Natural and Synthetic Cannabinoids and Their Synergistic Antiproliferative Effects with Cisplatin in Human Ovarian Cancer Cells

Zebrafish-Based Identification of Anti-seizure Compounds from Natural Products

Therapeutic implications of traditional Chinese medicine in clinically relevant diseases: Perspectives from microRNA-modulated apoptotic signaling

The role of artificial intelligence in drug screening, drug design, and clinical trials