Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 17 Jan 2025

Discovery of Novel and Highly Potent Small Molecule Inhibitors Targeting FLT3-ITD for the Treatment of Acute Myeloid Leukemia Using Structure-Based Virtual Screening and Biological Evaluation

in Experimental Pharmacology and Drug Discovery

Kun Shi
Ye Hong
Huajing Liu
Yanming Zhang
Fengzhen Wang
Xiaotian Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1511257

Original Research

Accepted on 17 Jan 2025

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

in Experimental Pharmacology and Drug Discovery

Zaishi Zhu
Zeling Huang
Chaofeng Zhang
Bo Xu
Hua Chen
Shuai Pei
Baofei Zhang
Lishi Jie
Xiaoqing Shi
Yu'ji'ang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501725

Review

Accepted on 17 Jan 2025

SOX9: A Key Transcriptional Regulator in Organ Fibrosis

in Experimental Pharmacology and Drug Discovery

Yishuo Li
Yue Xing
Ning Liu
Bin Liu
Zhihui Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507282

Original Research

Accepted on 17 Jan 2025

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

in Experimental Pharmacology and Drug Discovery

Meng Qiqi
Li Zhiping
He Xiaofeng
Luo Zhuohui
Hu Yingjie
Shen Xiao-Ling

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496511

Original Research

Published on 17 Jan 2025

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

in Experimental Pharmacology and Drug Discovery

Monika Jürgenson
Keerthana Chithanathan
Aivar Orav
Külli Jaako
Janeli Viil
Mithu Guha
Kalev Kask
Alexander Zharkovsky

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505729

392 views

Original Research

Accepted on 15 Jan 2025

Potential Efficacy and Mechanisms of Icariin for Animal Model of Osteonecrosis of the Femoral Head

in Experimental Pharmacology and Drug Discovery

Jie Xu
Wei Deng
Xun Zhu
Deyu Han
Yu Zheng
Qun Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1508971

Original Research

Published on 15 Jan 2025

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

in Experimental Pharmacology and Drug Discovery

Wenxin Zhang
Hongbo Teng
Tianyi Zhao
Roberts I. Eglitis
Xv Wang
Zhengxuan Yu
Shurong Qu
Haijing Wang
Yaru Zhao
Bowen Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518810

336 views

Original Research

Published on 15 Jan 2025

Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study

in Experimental Pharmacology and Drug Discovery

Yuan Liu
Jianjie Ouyang
Cuicui Zhang
Pingping Niu
Baoling Shang
Gengzhen Yao
Yongyong Shi
Xu Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1529167

135 views

Systematic Review

Published on 15 Jan 2025

Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies

in Experimental Pharmacology and Drug Discovery

Feng Zhang
Tao Li
Junli Wan
Lu Wang
Wenmei Guo
Yue Hu
Hao Wang
Wei Bian

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1521188

279 views

Original Research

Accepted on 14 Jan 2025

Integrating Traditional Omics and Machine Learning Approaches to Identify Microbial Biomarkers and Therapeutic Targets in Pediatric Inflammatory Bowel Disease

in Experimental Pharmacology and Drug Discovery

Lanlan Li
Xuzai Deng
Shuge Wang
Zhuyuan Huang
Huang Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545392

Editorial

Accepted on 14 Jan 2025

Editorial: Cell Cycle Modulators: Regulating the Basic Unit of Life for Disease Treatment and Tissue Regeneration

in Experimental Pharmacology and Drug Discovery

Roberta Giordo
Udhaya Kumar, Ph.D.,
Audra N Iness

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554529

Editorial

Accepted on 14 Jan 2025

Editorial: Advances in the Pharmacotherapy of Chronic Pelvic Pain Conditions

in Experimental Pharmacology and Drug Discovery

Elena Lucarini
Javier Aguilera-Lizarraga
Miguel Ángel Tejada Giráldez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546059

Editorial

Accepted on 14 Jan 2025

Editorial: Education and Training in Pharmaceutical Medicine, Medicines Development and Medicines Regulation

in Experimental Pharmacology and Drug Discovery

Bernd Rosenkranz
Tomoya Tachi
Andrei Mocan
Rolf Bass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544678

Editorial

Accepted on 14 Jan 2025

Editorial: Activation of the cGAS-STING Pathway by Extra-Nuclear DNA and its Pharmacognostic Modulation in Human Disease

in Experimental Pharmacology and Drug Discovery

Preston McCourt
Charles Day
Souren Paul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519429

Original Research

Published on 14 Jan 2025

Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies

in Experimental Pharmacology and Drug Discovery

Xiangjun Wang
Xiaowen Xia
Xianliang Song
Yi Zhou
Mingyu Ma
Yashuang Ren
Xitai Chen
Zenghui Xia
Yinghui Guo
Chunhong Song

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1525753

259 views

Original Research

Accepted on 13 Jan 2025

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs

in Experimental Pharmacology and Drug Discovery

Chongyang Shen
Qizheng Wang
Xun Ye
Yi Zhou
Huayang Xing
Chunjie Wu
Mingliang You

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1464525

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Articles

Discovery of Novel and Highly Potent Small Molecule Inhibitors Targeting FLT3-ITD for the Treatment of Acute Myeloid Leukemia Using Structure-Based Virtual Screening and Biological Evaluation

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

SOX9: A Key Transcriptional Regulator in Organ Fibrosis

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

Elocalcitol, a fluorinated vitamin D derivative, prevents high-fat diet-induced obesity via SCAP downregulation and miR-146a-associated mechanisms

Potential Efficacy and Mechanisms of Icariin for Animal Model of Osteonecrosis of the Femoral Head

The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity

Dexmedetomidine improves clinical outcomes in sepsis-induced myocardial injury: a retrospective cohort study

Protective effect of resveratrol on retinal damage in glaucoma: a systematic review and meta-analysis of preclinical studies

Integrating Traditional Omics and Machine Learning Approaches to Identify Microbial Biomarkers and Therapeutic Targets in Pediatric Inflammatory Bowel Disease

Editorial: Cell Cycle Modulators: Regulating the Basic Unit of Life for Disease Treatment and Tissue Regeneration

Editorial: Advances in the Pharmacotherapy of Chronic Pelvic Pain Conditions

Editorial: Education and Training in Pharmaceutical Medicine, Medicines Development and Medicines Regulation

Editorial: Activation of the cGAS-STING Pathway by Extra-Nuclear DNA and its Pharmacognostic Modulation in Human Disease

Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies

Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs