Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 11 Apr 2025

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

in Experimental Pharmacology and Drug Discovery

Bin Liao
Pan Wang
Sheng Gong
Lu Zhao
Jie Liu
Nan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575332

Review

Accepted on 10 Apr 2025

Hepatorenal Protective Effects of Essential Oils Against Chemical Overexposure Induced Oxidative Damage

in Experimental Pharmacology and Drug Discovery

Faming Jiang
Xiaoyan Huang
Xingying Chen
Yuanhua Xian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580805

Original Research

Accepted on 10 Apr 2025

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering Danazol versus Berotralstat

in Experimental Pharmacology and Drug Discovery

Mauro Cancian
Andrea Zanichelli
Dario Cattaneo
Antonio Gidaro
Riccardo Senter
Francesco Arcoleo
Pietro Andrea Accardo
Donatella Bignardi
Paolo Borrelli
Caterina Colangelo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550133

Original Research

Published on 09 Apr 2025

Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

in Experimental Pharmacology and Drug Discovery

Kai Gong
Shuang Zhou
Li Xiao
Mengzhen Xu
Yuhe Zhou
Kaihui Lu
Xin Yu
Jiang Zhu
Chuanguo Liu
Qingjun Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588375

162 views

Original Research

Published on 09 Apr 2025

Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats

in Experimental Pharmacology and Drug Discovery

Yang Bai
Rui Wang
Can Jin
Lili Wang
Yun Tang
Han Wang
Kan Ding
Shanjun Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1499420

131 views

Review

Published on 09 Apr 2025

Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

in Experimental Pharmacology and Drug Discovery

Xiaobei Lu
Yapeng Sun
Zhaoyi Zhang
Zhigang Sun
Shaohui Wang
Erping Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573684

137 views

Original Research

Published on 09 Apr 2025

Discovery of CMNPD31124 as a novel marine-derived PKMYT1 inhibitor for pancreatic ductal adenocarcinoma therapy: computational and biological insights

in Experimental Pharmacology and Drug Discovery

Chaojie Huang
Ting Wang
Rui Chen
Yunyun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569765

172 views

Original Research

Published on 09 Apr 2025

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay

in Experimental Pharmacology and Drug Discovery

Leire Borrega-Roman
Bradley L. Hoare
Miroslav Kosar
Roman C. Sarott
Kacper J. Patej
Jara Bouma
Morgan Scott-Dennis
Eline J. Koers
Thais Gazzi
Leonard Mach

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1469986

443 views

Original Research

Accepted on 08 Apr 2025

Combinatorial biosynthesis of novel gentamicin derivatives with nonsense mutation readthrough activity and low cytotoxicity

in Experimental Pharmacology and Drug Discovery

Lihua Yang
Hang Zhai
Tingting Tian
Botong Liu
Xianpu Ni
Huanzhang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575840

Original Research

Accepted on 08 Apr 2025

Wuling capsule alleviates hyperuricaemia and protects UA-injured HK-2 cells by regulating uric acid transporter proteins

in Experimental Pharmacology and Drug Discovery

Nan Li
Hongna Liu
Zhongxing Song
Rui Zhou
Zhishu Tang
Hongbo Xu
Xinbo Shi
Yan-Ru Liu
Jian Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563676

Original Research

Accepted on 08 Apr 2025

LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis

in Experimental Pharmacology and Drug Discovery

Yihan Liu
Long Cui
Runze Li
Dan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569644

Original Research

Accepted on 08 Apr 2025

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight on vascular dysfunction and hepatic steatosis

in Experimental Pharmacology and Drug Discovery

Abdullah Q Alsaedi
Manar Nader
Dalia H. El-Kashef
Marwa Abdelmageed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572758

Original Research

Published on 08 Apr 2025

Identification of novel amides and alkaloids as putative inhibitors of dopamine transporter for schizophrenia using computer-aided virtual screening

in Experimental Pharmacology and Drug Discovery

Iqra Ahmad
Anam Tassawer
Muhammad Umer Khan
Muhammad Shehroz
Umar Nishan
Sheheryar Sheheryar
Hanna Dib
Mohamed A. O. Abdelfattah
Mohibullah Shah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509263

436 views

Original Research

Published on 08 Apr 2025

Molecular mechanisms of the anchang group prescription in treating radiation enteritis: network pharmacology analysis and experimental evidence

in Experimental Pharmacology and Drug Discovery

Wei Liang
Bo Li
Yuehong Sun
Dapeng Jia
Tingting Hu
Rujing Huang
Zhilong Liu
Huan Yang
Baocai Chen
Xiaoming Yin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524925

161 views

Hypothesis and Theory

Published on 08 Apr 2025

Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter

in Experimental Pharmacology and Drug Discovery

Peter Buchwald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541872

129 views

Original Research

Published on 08 Apr 2025

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system

in Experimental Pharmacology and Drug Discovery

Dapeng Li
Yuanfan Li
Jie Cang
Xianwen Yan
Feipeng Wu
Xuan Sun
Wenchao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584245

144 views