Frontiers in Pharmacology | Drug Metabolism and Transport

Clinical Trial

Published on 17 May 2024

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects

in Drug Metabolism and Transport

Sisi Lin
Yutao Lou
Rui Hao
Yiming Shao
Jin Yu
Lu Fang
Meihua Bao
Wu Yi
Yiwen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1328142

1,540 views
3 citations

Original Research

Published on 16 May 2024

Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

in Drug Metabolism and Transport

Lorena Tamarit
Meryem El Ouardi
Emilio Lence
Inmaculada Andreu
Concepcion González-Bello
Miguel A. Miranda
Ignacio Vayá

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1387057

1,132 views

Original Research

Published on 10 May 2024

The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis

in Drug Metabolism and Transport

Zikai Song
Haidi Wu
Xiaoqi Fang
Xuemin Feng
Liting Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1336369

3,539 views
14 citations

Original Research

Published on 09 May 2024

Improving prediction of tacrolimus concentration using a combination of population pharmacokinetic modeling and machine learning in chinese renal transplant recipients

in Drug Metabolism and Transport

Yu-Ping Wang
Xiao-Ling Lu
Kun Shao
Hao-Qiang Shi
Pei-Jun Zhou
Bing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389271

2,109 views
2 citations

Review

Published on 07 May 2024

Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review

in Drug Metabolism and Transport

Yuhan Ma
Yongxia Zhao
Mingxia Luo
Qin Jiang
Sha Liu
Qi Jia
Zhixun Bai
Faming Wu
Jian Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1393409

3,986 views
9 citations

Original Research

Published on 02 May 2024

Population pharmacokinetics of intravenous daptomycin in critically ill patients: implications for selection of dosage regimens

in Drug Metabolism and Transport

Jianhua Wu
Xiangyi Zheng
Liu Zhang
Jiajun Wang
Yifei Lv
Yujie Xi
Dongfang Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378872

1,629 views

Original Research

Published on 02 May 2024

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

in Drug Metabolism and Transport

Yujie Yang
Xiqian Zhang
Yirong Wang
Heng Xi
Min Xu
Liang Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1342515

2,301 views

Original Research

Published on 29 Apr 2024

In vitro and in vivo metabolism of psilocybin’s active metabolite psilocin

in Drug Metabolism and Transport

Jan Thomann
Karolina E. Kolaczynska
Oliver V. Stoeckmann
Deborah Rudin
Patrick Vizeli
Marius C. Hoener
Christopher R. Pryce
Franz X. Vollenweider
Matthias E. Liechti
Urs Duthaler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1391689

12,590 views
15 citations

Original Research

Published on 29 Apr 2024

The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses

in Drug Metabolism and Transport

Yuanxun Yang
Lei Yu
Zejuan Sheng
Hui Lin
Zuyi Weng
Wei Song
Bei Cao
Yu Zhao
Yingsheng Gao
Shumao Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1327008

1,721 views
2 citations

Original Research

Published on 29 Apr 2024

The impacts of natural product miltirone and the CYP2D6 pharmacogenetic phenotype on fluoxetine metabolism

in Drug Metabolism and Transport

Xiaodan Zhang
Qingqing Li
Xinwu Ye
Qing Chen
Chen Chen
Guoxin Hu
Likang Zhang
Lianguo Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1373048

1,215 views
1 citation

Original Research

Published on 19 Apr 2024

Investigation of the hypoglycemic mechanism of the ShenQi compound formula through metabonomics and 16S rRNA sequencing

in Drug Metabolism and Transport

Juan Gao
Xiujuan Zhou
Hong Gao
Guiping Xu
Chunguang Xie
Hongyan Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1349244

1,712 views
2 citations

Original Research

Published on 09 Apr 2024

Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin

in Drug Metabolism and Transport

Boshen Li
Yuxuan Zhang
Zhiqiang Yang
Xiaolin Li
Jun Yang
Kai Luo
Renjie Wang
Chengrong Xiao
Maoxing Li
Yue Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1364286

1,257 views
1 citation

Original Research

Published on 08 Apr 2024

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism

in Drug Metabolism and Transport

Yu Wang
Quan Zhou
Huihui Wang
Wei Song
Jianfeng Wang
Abdullah Al Mamun
Peiwu Geng
Yunfang Zhou
Shuanghu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1351882

1,378 views
2 citations

Clinical Trial

Published on 04 Apr 2024

Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

in Drug Metabolism and Transport

Miłosz Miedziaszczyk
Marek Karczewski
Tomasz Grabowski
Anna Wolc
Ilona Idasiak-Piechocka

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352323

2,804 views
4 citations

Original Research

Published on 02 Apr 2024

Pharmacokinetics of desflurane uptake and disposition in piglets

in Drug Metabolism and Transport

Chih-Cherng Lu
Shung-Tai Ho
Oliver Yao-Pu Hu
Cheng-Huei Hsiong
Yuan-Chen Cheng
Che-Hao Hsu
Tso-Chou Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1339690

3,614 views

Original Research

Published on 27 Mar 2024

Clinical and pharmacological factors influencing serum clozapine and norclozapine levels

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwoń-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1356813

2,078 views
2 citations