Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 12 Sep 2024

Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism

in Drug Metabolism and Transport

Hailun Xia
Xinhao Xu
Jie Chen
Hualu Wu
Yuxin Shen
Xiaohai Chen
Ren-ai Xu
Wenzhi Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403649

1,306 views

Original Research

Published on 06 Sep 2024

Exploring pharmacokinetic variability of palbociclib in HR+/HER2- metastatic breast cancer: a focus on age, renal function, and drug–gene interactions

in Drug Metabolism and Transport

Elena Peruzzi
Bianca Posocco
Lorenzo Gerratana
Margherita Nuti
Marco Orleni
Sara Gagno
Elena De Mattia
Fabio Puglisi
Erika Cecchin
Giuseppe Toffoli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1420174

1,355 views
2 citations

Original Research

Published on 26 Aug 2024

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423175

1,333 views
1 citation

Original Research

Published on 26 Aug 2024

In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others

in Drug Metabolism and Transport

Junjun Mao
Feifei Yu
Weiwei Qin
Guixian She
Yi Rong
Zhuohan Hu
Mingkang Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1443794

1,536 views

Original Research

Published on 23 Aug 2024

Population pharmacokinetics study of tacrolimus in liver transplant recipients: a comparison between patients with or without liver cancer before surgery

in Drug Metabolism and Transport

Haihong Bai
Juping Yun
Zihe Wang
Yingmin Ma
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449535

1,159 views

Original Research

Published on 23 Aug 2024

Enhanced anti-inflammatory activity of chlorogenic acid via folic acid-TPGS-modified liposomes encapsulation: characterization and In vivo evaluation on colitis mice

in Drug Metabolism and Transport

Qing-qing Li
Jia-hui Yan
Zhi-e Zhou
Xiang Geng
Jian-hua Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1437773

1,410 views
2 citations

Original Research

Published on 21 Aug 2024

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

in Drug Metabolism and Transport

Godefridus J. Peters
Ietje Kathmann
Elisa Giovannetti
Kees Smid
Yehuda G. Assaraf
Gerrit Jansen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1450418

2,008 views
1 citation

Original Research

Published on 20 Aug 2024

Effects of three flavonoids on the metabolism of lenvatinib

in Drug Metabolism and Transport

Jinzhao Yang
Jie Chen
Qingqing Li
Ren-ai Xu
Xiaohai Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1438259

1,162 views
1 citation

Original Research

Published on 20 Aug 2024

Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis

in Drug Metabolism and Transport

Jing Ling
Xuping Yang
Lulu Dong
Yan Jiang
Sulan Zou
Nan Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1455721

1,245 views
1 citation

Original Research

Published on 16 Aug 2024

A simple HPLC–MS/MS method for the determination of polymyxin B in human plasma and its application in the pharmacokinetic study in elderly patients infected with multidrug-resistant Gram-negative bacteria

in Drug Metabolism and Transport

Sheng Hu
Nan Guo
Juan Zeng
Yue Li
Yahui Zhang
Jinjiao Jiang
Bing Leng
Chengwu Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1396307

2,365 views

Review

Published on 12 Aug 2024

Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update

in Drug Metabolism and Transport

Mingli Sun
Xin Zhang
Boxuan Tan
Qingya Zhang
Xiaopeng Zhao
Dan Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415108

2,231 views
3 citations

Original Research

Published on 07 Aug 2024

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

in Drug Metabolism and Transport

Jhohann Richard de Lima Benzi
Yik Pui Tsang
Jashvant D. Unadkat

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440010

2,294 views
3 citations

Original Research

Published on 07 Aug 2024

Exploring stevioside binding affinity with various proteins and receptors actively involved in the signaling pathway and a future candidate for diabetic patients

in Drug Metabolism and Transport

Salman Khan
Nisar Ahmad
Hina Fazal
Ibrahim A. Saleh
Mostafa A. Abdel-Maksoud
Abdul Malik
Gehad AbdElgayed
Arshad Jalal
Kamran Rauf
Liaqat Ali

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377916

2,217 views
3 citations

Editorial

Published on 05 Aug 2024

Editorial: Pharmacokinetic-pharmacodynamic model of drugs and their pharmacokinetic differences between normal and disease states

in Drug Metabolism and Transport

Zipeng Gong
Ruixing Chen
Ling Ye
Guo Ma
Yanfang Xian
Kaustubh Kulkarni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451176

957 views

Correction

Published on 01 Aug 2024

Corrigendum: Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury

in Drug Metabolism and Transport

Xinzhu Zhang
Wu Xiong
Guang Kong
Yushan Zhen
Qiang Zeng
Siming Wang
Sheng Chen
Jun Gu
Cong Li
Kaijin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1451951

766 views

Review

Published on 24 Jul 2024

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs

in Drug Metabolism and Transport

Yimei Wang
Mei-Juan Tu
Ai-Ming Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423416

2,874 views
4 citations