Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 09 Jan 2025

UGT2B15 single nucleotide polymorphism reduces dabigatran acylglucuronide formation in humans

in Drug Metabolism and Transport

Jin-Woo Park
Jong-Min Kim
Young Yoon Bang
Kyoung-Ah Kim
Sungwook Yu
Ji-Young Park

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1507915

542 views

Original Research

Published on 08 Jan 2025

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

in Drug Metabolism and Transport

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
Zhilin Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1510903

714 views

Original Research

Published on 08 Jan 2025

stormTB: a web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

in Drug Metabolism and Transport

Roberto Visintainer
Anna Fochesato
Daniele Boaretti
Stefano Giampiccolo
Shayne Watson
Micha Levi
Federico Reali
Luca Marchetti

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1462193

600 views

Original Research

Published on 07 Jan 2025

LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia

in Drug Metabolism and Transport

Mihaela Butiulca
Lenard Farczadi
Silvia Imre
Camil Eugen Vari
Laurian Vlase
Bogdan Cordos
Leonard Azamfirei
Alexandra Elena Lazar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494646

593 views

Original Research

Published on 07 Jan 2025

The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients

in Drug Metabolism and Transport

Anna Mach
Anna Wnorowska
Marcin Siwek
Marcin Wojnar
Maria Radziwoń-Zaleska

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1518739

637 views

Methods

Published on 06 Jan 2025

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma

in Drug Metabolism and Transport

Jiahui Lin
Aiting Jiang
Juntao Zheng
Jingjing Wu
Hao Li
Shirong Cai
Yulong He
Xiao Chen
Guoping Zhong
Ke-Jing Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1506931

585 views
1 citation

Original Research

Published on 03 Jan 2025

Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling pathway

in Drug Metabolism and Transport

Xiaokang Wang
Chunxiao Ye
Xixiao Yang
Maoxun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1522271

605 views

Clinical Trial

Published on 03 Jan 2025

Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial

in Drug Metabolism and Transport

Bo Qiu
Haojing Song
Xue Sun
Congyang Ding
Runxuan Du
Wanjun Bai
Zhanjun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1511214

523 views

Original Research

Published on 03 Jan 2025

Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects

in Drug Metabolism and Transport

Feng Cheng
Tao Shen
Fucheng Zhang
Chenghao Lei
Ye Zhu
GuoJun Luo
Dawei Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452596

941 views

Original Research

Published on 19 Dec 2024

Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS

in Drug Metabolism and Transport

Wei Lu
Rong Zeng
Meng Pan
Yuan Zhou
Huijuan Tang
Wanying Shen
Yijun Tang
Pan Lei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1509319

1,255 views

Original Research

Published on 16 Dec 2024

Population pharmacokinetic and pharmacodynamic model guided weight-tiered dose of AST-001 in pediatric patients with autism spectrum disorder

in Drug Metabolism and Transport

Soyoung Lee
Su-Kyeong Hwang
Jung-Sook Cho
Hyung Chul Ryu
Jae-Yong Chung

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1452526

1,018 views

Original Research

Published on 05 Dec 2024

Mass balance, metabolic disposition, and pharmacokinetics of a single IV dose of [14C]CA102N in HT-29 xenograft athymic nude mice

in Drug Metabolism and Transport

Eskouhie Tchaparian
Hua-Yang Lin
Yuchih Chen
J. Neil Hunter
Sindy Yin
Huey Ng
Albert Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1440679

851 views

Original Research

Published on 04 Dec 2024

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats

in Drug Metabolism and Transport

Dongxin Chen
Jie Chen
Hailun Xia
Xiaohai Chen
Jinyu Hu
Guangliang Wu
Xuegu Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1498339

648 views

Original Research

Published on 04 Dec 2024

Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study

in Drug Metabolism and Transport

Tayyaba Iftikhar
Zafar Iqbal
Yasar Shah
Nauman Rahim Khan
Muhammad Abbas
Omer Shehzad
Fazal Hadi
Haseeba Sardar
Ali Abusharha
Maria Daglia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467805

1,451 views

Original Research

Published on 03 Dec 2024

Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

in Drug Metabolism and Transport

Maja Đanić
Nebojša Pavlović
Dragana Zaklan
Bojan Stanimirov
Slavica Lazarević
Hani Al-Salami
Momir Mikov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1492284

741 views

Original Research

Published on 20 Nov 2024

Mulberry leaf ameliorate STZ induced diabetic rat by regulating hepatic glycometabolism and fatty acid β-oxidation

in Drug Metabolism and Transport

Bohan Lv
Siyuan Liu
Yaqi Li
Zhigang Li
Yongcheng An
Changhao He
Huilin Zhang
Yan Huang
Wanxin Fu
Quantao Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1428604

1,727 views