Original Research

Published on 15 Apr 2021

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

in Drug Metabolism and Transport

Pengfei Li
Jun Peng
Yuexin Li
Lili Gong
Yali Lv
He Liu
Tianhong Zhang
Song Yang
Hongchuan Liu
Jinglai Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.621003

5,351 views
5 citations

Review

Published on 14 Apr 2021

Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction?

in Drug Metabolism and Transport

Christoph Wenzel
Marek Drozdzik
Stefan Oswald

Frontiers in Pharmacology

doi 10.3389/fphar.2021.648388

6,006 views
12 citations

Clinical Trial

Published on 17 Mar 2021

A Phase I, Randomized, Single-Dose Study to Evaluate the Biosimilarity of HOT-3010 to Adalimumab Among Healthy Chinese Male Subjects

in Drug Metabolism and Transport

Hong Zhang
Hong Chen
Xiaojiao Li
Min Wu
Xiaoxue Zhu
Cuiyun Li
Jingrui Liu
Haijing Wei
Yue Hu
Jingjing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.646171

3,101 views

Clinical Trial

Published on 10 Mar 2021

The Bioequivalence of Emulsified Isoflurane With a New Formulation of Emulsion: A Single-Center, Single-Dose, Double-Blinded, Randomized, Two-Period Crossover Study

in Drug Metabolism and Transport

Hui Yang
Qinqin Yin
Luying Huang
Min Zhang
Xinxin Zhang
Qirong Sun
Xuewei Liu
Qi Wang
Xi Yang
Lingcan Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.626307

2,599 views
2 citations

Original Research

Published on 08 Mar 2021

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

in Drug Metabolism and Transport

Muhammad Erfan Uddin
Dominique A. Garrison
Kyeongmin Kim
Yan Jin
Eric D. Eisenmann
Kevin M. Huang
Alice A. Gibson
Zeping Hu
Alex Sparreboom
Shuiying Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.644342

4,680 views
15 citations

Original Research

Published on 04 Mar 2021

The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers

in Drug Metabolism and Transport

Aleš Dvořák
Kateřina Pospíšilová
Kateřina Žížalová
Nikola Capková
Lucie Muchová
Marek Vecka
Nikola Vrzáčková
Jana Křížová
Jaroslav Zelenka
Libor Vítek

Frontiers in Pharmacology

doi 10.3389/fphar.2021.567001

6,223 views
13 citations

Original Research

Published on 04 Mar 2021

Study on Acute Toxicity of Amiodarone New Complexes With Cyclodextrin

in Drug Metabolism and Transport

Cristina Mihaela Ghiciuc
Maytham Razaq Shleghm
Cornelia Vasile
Gladiola Tantaru
Andreea Creteanu
Lacramioara Ochiuz

Frontiers in Pharmacology

doi 10.3389/fphar.2021.640705

3,161 views
4 citations

Original Research

Published on 18 Feb 2021

Bryophyllum pinnatum Compounds Inhibit Oxytocin-Induced Signaling Pathways in Human Myometrial Cells

in Drug Metabolism and Transport

Stefanie Santos
Leonie Zurfluh
Mónica Mennet
Olivier Potterat
Ursula von Mandach
Matthias Hamburger
Ana Paula Simões-Wüst

Frontiers in Pharmacology

doi 10.3389/fphar.2021.632986

5,204 views
11 citations

Review

Published on 17 Feb 2021

Drug-Drug Interactions at Organic Cation Transporter 1

in Drug Metabolism and Transport

Shiwei Zhou
Sujuan Zeng
Yan Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.628705

10,450 views
27 citations

Original Research

Published on 15 Feb 2021

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

in Drug Metabolism and Transport

Bridget L. Morse
Lisa Hong Chen
John T. Catlow
John K. Fallon
Philip C. Smith
Kathleen M. Hillgren

Frontiers in Pharmacology

doi 10.3389/fphar.2021.631793

2,007 views

Original Research

Published on 15 Feb 2021

Estimation of the In Vivo Release of Amiodarone From the Pharmacokinetics of Its Active Metabolite and Correlation With Its In Vitro Release

in Drug Metabolism and Transport

Maytham Razaq Shleghm
Constantin Mircioiu
Victor A. Voicu
Ion Mircioiu
Valentina Anuta

Frontiers in Pharmacology

doi 10.3389/fphar.2020.621667

3,662 views
6 citations

Original Research

Published on 12 Feb 2021

Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients

in Drug Metabolism and Transport

Miao Zhang
Xueting Yao
Zhe Hou
Xuan Guo
Siqi Tu
Zihan Lei
Zhiheng Yu
Xuanlin Liu
Cheng Cui
Xijing Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2020.585021

5,636 views
7 citations

Original Research

Published on 08 Feb 2021

Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ

in Drug Metabolism and Transport

Ya-Di Zhu
Xiao-Qing Guan
Jing Chen
Sheng Peng
Moshe Finel
Ying-Yuan Zhao
Rui-Min Wang
Hui-Chang Bi
Ming Lei
Dan-Dan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2020.628314

7,856 views
16 citations

Methods

Published on 05 Feb 2021

In vivo Pharmacokinetic Drug-Drug Interaction Studies Between Fedratinib and Antifungal Agents Based on a Newly Developed and Validated UPLC/MS-MS Method

in Drug Metabolism and Transport

Congrong Tang
Xiaohui Niu
Lu Shi
Huidan Zhu
Guanyang Lin
Ren-ai Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2020.626897

4,034 views
46 citations

Mini Review

Published on 01 Feb 2021

Potency, Safety, and Pharmacokinetic Profiles of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

in Drug Metabolism and Transport

Hylemariam Mihiretie Mengist
Daniel Mekonnen
Ahmed Mohammed
Ronghua Shi
Tengchuan Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2020.630500

9,530 views
36 citations

Original Research

Published on 29 Jan 2021

A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects

in Drug Metabolism and Transport

Gang Mai
Lianlian Fan
Mupeng Li
Peiwen Zhang
Chunyan Gan
Qian Huang
Jianzhong Shentu

Frontiers in Pharmacology

doi 10.3389/fphar.2020.610880

6,516 views
5 citations

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Articles

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction?

A Phase I, Randomized, Single-Dose Study to Evaluate the Biosimilarity of HOT-3010 to Adalimumab Among Healthy Chinese Male Subjects

The Bioequivalence of Emulsified Isoflurane With a New Formulation of Emulsion: A Single-Center, Single-Dose, Double-Blinded, Randomized, Two-Period Crossover Study

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers

Study on Acute Toxicity of Amiodarone New Complexes With Cyclodextrin

Bryophyllum pinnatum Compounds Inhibit Oxytocin-Induced Signaling Pathways in Human Myometrial Cells

Drug-Drug Interactions at Organic Cation Transporter 1

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

Estimation of the In Vivo Release of Amiodarone From the Pharmacokinetics of Its Active Metabolite and Correlation With Its In Vitro Release

Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients

Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ

In vivo Pharmacokinetic Drug-Drug Interaction Studies Between Fedratinib and Antifungal Agents Based on a Newly Developed and Validated UPLC/MS-MS Method

Potency, Safety, and Pharmacokinetic Profiles of Potential Inhibitors Targeting SARS-CoV-2 Main Protease

A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza®) in Healthy Male Subjects