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Original Research

Published on 13 Aug 2021

(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells

in Drug Metabolism and Transport

  • Alzbeta Stefela
  • Miroslav Kaspar
  • Martin Drastik
  • Thales Kronenberger
  • Stanislav Micuda
  • Martin Dracinsky
  • Blanka Klepetarova
  • Eva Kudova
  • Petr Pavek
(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells
Frontiers in Pharmacology
doi 10.3389/fphar.2021.713149
  • 5,383 views
  • 6 citations