Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 19 Oct 2022

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

in Drug Metabolism and Transport

Tingting Ma
Yanli Dong
Lei Huang
Yuanxun Yang
Yan Geng
Fei Fei
Pinhao Xie
Yu Zhao
Hui Lin
Zeyu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1027627

3,659 views
10 citations

Correction

Published on 14 Oct 2022

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

in Drug Metabolism and Transport

Lingfei Huang
Junyan Wang
Jufei Yang
Huifen Zhang
Yan Hu
Jing Miao
Jianhua Mao
Luo Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1051794

829 views

Original Research

Published on 13 Oct 2022

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

in Drug Metabolism and Transport

Jianbo Huang
Hong Wang
Lei Huang
Yuqing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.968835

1,542 views
1 citation

Review

Published on 11 Oct 2022

The status of industrialization and development of exosomes as a drug delivery system: A review

in Drug Metabolism and Transport

Yi Yin
Xing Han
Cheng Li
Tonghui Sun
Kailin Li
Xionghao Liu
Mujun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.961127

4,023 views
12 citations

Methods

Published on 11 Oct 2022

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

in Drug Metabolism and Transport

Kai On Chu
Gene Chi Wai Man
Sze Wan Hung
Tak Hang Chan
Wai Yip Thomas Lee
Kwok Ping Chan
Chi Pui Pang
Chi Chiu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1025053

2,037 views

Review

Published on 10 Oct 2022

Application of traditional Chinese medicine in film drug delivery system

in Drug Metabolism and Transport

Qianhang Li
Feng Luo
Pingnan Jiang
Chenxi Feng
Feifei He
Lina Dong
Delin Xu
Junhua Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2022.956264

12,250 views
3 citations

Original Research

Published on 10 Oct 2022

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

in Drug Metabolism and Transport

Lu Chen
Chao Li
Hao Bai
Lixian Li
Wanyi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2022.960186

2,783 views
5 citations

Original Research

Published on 07 Oct 2022

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

in Drug Metabolism and Transport

Muhammad Talha Saleem
Muhammad Harris Shoaib
Rabia Ismail Yousuf
Farrukh Rafiq Ahmed
Kamran Ahmed
Fahad Siddiqui
Zafar Alam Mahmood
Muhammad Sikandar
Muhammad Suleman Imtiaz

Frontiers in Pharmacology

doi 10.3389/fphar.2022.974715

6,398 views
4 citations

Review

Published on 07 Oct 2022

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

in Drug Metabolism and Transport

Liu Liu
Yiming Liu
Xiaojie Zhou
Zhiwei Xu
Yehui Zhang
Liting Ji
Chunlan Hong
Changyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.962718

5,938 views
3 citations

Original Research

Published on 05 Oct 2022

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

in Drug Metabolism and Transport

Chaozhuang Shen
Dahu Liang
Xiaohu Wang
Wenxin Shao
Kuo Geng
Xingwen Wang
Hua Sun
Haitang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1013432

3,322 views
13 citations

Correction

Published on 05 Oct 2022

Corrigendum: Evaluation of herb–drug interaction between Danshen and rivaroxaban in rat and human liver microsomes

in Drug Metabolism and Transport

Xu Wang
Jingjing Fa
Yuanjin Zhang
Shengbo Huang
Jie Liu
Junqing Gao
Lina Xing
Zongjun Liu
Xin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1039267

1,176 views

Original Research

Published on 05 Oct 2022

Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states

in Drug Metabolism and Transport

Xinyao Qu
Qiaohuan Deng
Ying Li
Peng Li
Guangwen Liu
Yanli Wang
Zhengzhi Liu
Shuang Yu
Yang Cheng
Yannan Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1012294

3,317 views
4 citations

Original Research

Published on 04 Oct 2022

Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

in Drug Metabolism and Transport

Jiahong Xiang
Mengqi Wu
Jianchao Wang
Mengmeng Lin
Mengmeng Sun
Xin Li
Ruijuan Xing
Ran Guo
Jianmin Gu
Tao Lyu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1001308

3,796 views
2 citations

Original Research

Published on 04 Oct 2022

Formulation of ciprofloxacin-loaded oral self-emulsifying drug delivery system to improve the pharmacokinetics and antibacterial activity

in Drug Metabolism and Transport

Asghar Ali Asghar
Muhammad Akhlaq
Aamir Jalil
Abul Kalam Azad
Junaid Asghar
Muhammad Adeel
Ghadeer M. Albadrani
Amin A. Al-Doaiss
Mohamed Kamel
Ahmed E. Altyar

Frontiers in Pharmacology

doi 10.3389/fphar.2022.967106

5,336 views
8 citations

Original Research

Published on 30 Sep 2022

Pharmacokinetic study of single and multiple oral administration of glutamine in healthy Beagles

in Drug Metabolism and Transport

Fanxi Guo
Dongying Liu
Yuqing Zhou
Yuanqian Yu
Yidan Xu
Yuanpeng Zou
Chongyang Li
Fengyichi Zhang
Zugong Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1014474

2,964 views

Original Research

Published on 30 Sep 2022

External evaluation of published population pharmacokinetic models of posaconazole

in Drug Metabolism and Transport

Shuqi Huang
Qin Ding
Nan Yang
Zexu Sun
Qian Cheng
Wei Liu
Yejun Li
Xin Chen
Cuifang Wu
Qi Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1005348

2,532 views
5 citations