Original Research

Published on 26 Aug 2022

Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

in Drug Metabolism and Transport

Hongrui Liu
Yiqun Yu
Lu Liu
Chunyan Wang
Nan Guo
Xiaojuan Wang
Xiaoqiang Xiang
Bing Han

Frontiers in Pharmacology

doi 10.3389/fphar.2022.970539

2,768 views
4 citations

Original Research

Published on 24 Aug 2022

Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters

in Drug Metabolism and Transport

Parisa Ghasemiyeh
Afsaneh Vazin
Farid Zand
Elham Haem
Iman Karimzadeh
Amir Azadi
Mansoor Masjedi
Golnar Sabetian
Reza Nikandish
Soliman Mohammadi-Samani

Frontiers in Pharmacology

doi 10.3389/fphar.2022.912202

4,054 views
4 citations

Original Research

Published on 23 Aug 2022

A randomized, double-blind, parallel control study to evaluate the biosimilarity of QL1209 with Perjeta® in healthy male subjects

in Drug Metabolism and Transport

Yuanyuan Sun
Heng Yang
Xiaoyan Yang
Shuang Yang
Can Guo
Honghui Chen
Chang Cui
Yuxia Xiang
Guoping Yang
Jie Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.953641

2,409 views
2 citations

Original Research

Published on 23 Aug 2022

Dex modulates the balance of water-electrolyte metabolism by depressing the expression of AVP in PVN

in Drug Metabolism and Transport

Wenzhi Yang
Hao Li
Zhongle Cheng
You Lu
Wuli Li
Jun Feng
Liecheng Wang
Juan Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.919032

3,581 views
11 citations

Clinical Trial

Published on 22 Aug 2022

Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

in Drug Metabolism and Transport

Inyoung Hwang
Sang Won Lee
Jaeseong Oh
SeungHwan Lee
In-Jin Jang
Kyung-Sang Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.930615

1,530 views
2 citations

Original Research

Published on 22 Aug 2022

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP/P-gp

in Drug Metabolism and Transport

Tingting Zhao
Xuening Li
Yanwei Chen
Jie Du
Xiaodong Chen
Dalong Wang
Liyan Wang
Shan Zhao
Changyuan Wang
Qiang Meng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.914842

3,620 views
7 citations

Original Research

Published on 22 Aug 2022

Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

in Drug Metabolism and Transport

Chaitali Ghosh
Rosemary Westcott
Emilio Perucca
Mohammed Hossain
William Bingaman
Imad Najm

Frontiers in Pharmacology

doi 10.3389/fphar.2022.983233

3,407 views
1 citation

Clinical Trial

Published on 19 Aug 2022

A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects

in Drug Metabolism and Transport

Xingjiang Hu
Qiao Zhang
Yunliang Zheng
You Zhai
Nana Xu
Qingwei Zhao
Jian Liu
Longyan Wan
Jindan Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2022.946505

4,044 views
1 citation

Original Research

Published on 17 Aug 2022

Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver

in Drug Metabolism and Transport

Marwa Tantawy
Joseph M. Collins
Danxin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.943538

2,438 views
6 citations

Methods

Published on 17 Aug 2022

Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method

in Drug Metabolism and Transport

Fulin Jiang
Chang Zhang
Zihan Lu
Jingyu Liu
Peiqing Liu
Min Huang
Guoping Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.906027

2,833 views
1 citation

Original Research

Published on 16 Aug 2022

Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo

in Drug Metabolism and Transport

Yiran Wang
Jihua Shi
Dapeng Dai
Jianping Cai
Shuanghu Wang
Yun Hong
Shan Zhou
Fangling Zhao
Quan Zhou
Peiwu Geng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.909168

4,123 views
6 citations

Original Research

Published on 16 Aug 2022

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

in Drug Metabolism and Transport

Lingling Ye
Xiang You
Jie Zhou
Chaohui Wu
Meng Ke
Wanhong Wu
Pinfang Huang
Cuihong Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2022.838599

3,183 views
7 citations

Original Research

Published on 16 Aug 2022

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

in Drug Metabolism and Transport

Amy Q. Wang
Natalie R. Hagen
Elias C. Padilha
Mengbi Yang
Pranav Shah
Catherine Z. Chen
Wenwei Huang
Pramod Terse
Philip Sanderson
Wei Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.918083

5,064 views
17 citations

Original Research

Published on 16 Aug 2022

Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis

in Drug Metabolism and Transport

Qian Li
Ju Qiao
Hongzhong Jin
Benchao Chen
Zhimei He
Guoqin Wang
Xiang Ni
Max Wang
Michelle Xia
Baiyong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.966176

2,690 views
1 citation

Original Research

Published on 12 Aug 2022

Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine

in Drug Metabolism and Transport

Piao-Piao Huang
Wen-Qiang Zhu
Jing-Mei Xiao
Yi-Qi Zhang
Rong Li
Yang Yang
Li Shen
Fei Luo
Wen Dai
Ping-An Lian

Frontiers in Pharmacology

doi 10.3389/fphar.2022.935362

3,200 views
5 citations

Original Research

Published on 12 Aug 2022

Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7

in Drug Metabolism and Transport

Jia Xue
Haitao Zhang
Su Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.965038

2,081 views

Navigation group

Articles

Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

Pharmacokinetic assessment of vancomycin in critically ill patients and nephrotoxicity prediction using individualized pharmacokinetic parameters

A randomized, double-blind, parallel control study to evaluate the biosimilarity of QL1209 with Perjeta® in healthy male subjects

Dex modulates the balance of water-electrolyte metabolism by depressing the expression of AVP in PVN

Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

Risk assessment and molecular mechanism study of drug-drug interactions between rivaroxaban and tyrosine kinase inhibitors mediated by CYP2J2/3A4 and BCRP/P-gp

Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone® 3.75 mg in healthy male subjects

Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver

Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method

Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis

Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine

Integrate thermostabilized fusion protein apocytochrome b562RIL and N-glycosylation mutations: A novel approach to heterologous expression of human UDP-glucuronosyltransferase (UGT) 2B7