Original Research

Published on 25 Oct 2022

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

in Drug Metabolism and Transport

Ziqiang Li
Xi Du
Shuang Tian
Shanshan Fan
Xurui Zuo
Yanfen Li
Ruihua Wang
Baohe Wang
Yuhong Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1033667

2,283 views
1 citation

Original Research

Published on 24 Oct 2022

Plasma metabolomic and lipidomic alterations associated with anti-tuberculosis drug-induced liver injury

in Drug Metabolism and Transport

Ming-Gui Wang
Shou-Quan Wu
Meng-Meng Zhang
Jian-Qing He

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1044808

3,656 views
12 citations

Original Research

Published on 24 Oct 2022

Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

in Drug Metabolism and Transport

Junjun Mao
Yuhao Chen
Luyang Xu
Weihuang Chen
Biwen Chen
Zhuo Fang
Weiwei Qin
Mingkang Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1016399

3,563 views
7 citations

Original Research

Published on 21 Oct 2022

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

in Drug Metabolism and Transport

Yueqiu Liu
Xinyi Hu
Wen Zheng
Lu Zhang
Luolan Gui
Ge Liang
Yong Zhang
Liqiang Hu
Xin Li
Yi Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1011608

3,170 views
6 citations

Original Research

Published on 19 Oct 2022

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

in Drug Metabolism and Transport

Tingting Ma
Yanli Dong
Lei Huang
Yuanxun Yang
Yan Geng
Fei Fei
Pinhao Xie
Yu Zhao
Hui Lin
Zeyu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1027627

2,982 views
7 citations

Correction

Published on 14 Oct 2022

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

in Drug Metabolism and Transport

Lingfei Huang
Junyan Wang
Jufei Yang
Huifen Zhang
Yan Hu
Jing Miao
Jianhua Mao
Luo Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1051794

736 views

Original Research

Published on 13 Oct 2022

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

in Drug Metabolism and Transport

Jianbo Huang
Hong Wang
Lei Huang
Yuqing Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.968835

1,321 views
1 citation

Methods

Published on 11 Oct 2022

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

in Drug Metabolism and Transport

Kai On Chu
Gene Chi Wai Man
Sze Wan Hung
Tak Hang Chan
Wai Yip Thomas Lee
Kwok Ping Chan
Chi Pui Pang
Chi Chiu Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1025053

1,751 views

Review

Published on 11 Oct 2022

The status of industrialization and development of exosomes as a drug delivery system: A review

in Drug Metabolism and Transport

Yi Yin
Xing Han
Cheng Li
Tonghui Sun
Kailin Li
Xionghao Liu
Mujun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.961127

3,199 views
9 citations

Review

Published on 10 Oct 2022

Application of traditional Chinese medicine in film drug delivery system

in Drug Metabolism and Transport

Qianhang Li
Feng Luo
Pingnan Jiang
Chenxi Feng
Feifei He
Lina Dong
Delin Xu
Junhua Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2022.956264

8,774 views
3 citations

Original Research

Published on 10 Oct 2022

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

in Drug Metabolism and Transport

Lu Chen
Chao Li
Hao Bai
Lixian Li
Wanyi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2022.960186

2,491 views
3 citations

Original Research

Published on 07 Oct 2022

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

in Drug Metabolism and Transport

Muhammad Talha Saleem
Muhammad Harris Shoaib
Rabia Ismail Yousuf
Farrukh Rafiq Ahmed
Kamran Ahmed
Fahad Siddiqui
Zafar Alam Mahmood
Muhammad Sikandar
Muhammad Suleman Imtiaz

Frontiers in Pharmacology

doi 10.3389/fphar.2022.974715

4,422 views
3 citations

Review

Published on 07 Oct 2022

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

in Drug Metabolism and Transport

Liu Liu
Yiming Liu
Xiaojie Zhou
Zhiwei Xu
Yehui Zhang
Liting Ji
Chunlan Hong
Changyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.962718

4,762 views
1 citation

Original Research

Published on 05 Oct 2022

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

in Drug Metabolism and Transport

Chaozhuang Shen
Dahu Liang
Xiaohu Wang
Wenxin Shao
Kuo Geng
Xingwen Wang
Hua Sun
Haitang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1013432

2,886 views
10 citations

Correction

Published on 05 Oct 2022

Corrigendum: Evaluation of herb–drug interaction between Danshen and rivaroxaban in rat and human liver microsomes

in Drug Metabolism and Transport

Xu Wang
Jingjing Fa
Yuanjin Zhang
Shengbo Huang
Jie Liu
Junqing Gao
Lina Xing
Zongjun Liu
Xin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1039267

990 views

Original Research

Published on 05 Oct 2022

Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states

in Drug Metabolism and Transport

Xinyao Qu
Qiaohuan Deng
Ying Li
Peng Li
Guangwen Liu
Yanli Wang
Zhengzhi Liu
Shuang Yu
Yang Cheng
Yannan Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1012294

2,857 views
4 citations

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Articles

Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment with Polygonum capitatum Buch.-Ham. ex D. Don extracts

Plasma metabolomic and lipidomic alterations associated with anti-tuberculosis drug-induced liver injury

Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

Corrigendum: Impact of sampling time variability on tacrolimus dosage regimen in pediatric primary nephrotic syndrome: Single-center, prospective, observational study

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry

The status of industrialization and development of exosomes as a drug delivery system: A review

Application of traditional Chinese medicine in film drug delivery system

Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

Predictive performance and verification of physiologically based pharmacokinetic model of propylthiouracil

Corrigendum: Evaluation of herb–drug interaction between Danshen and rivaroxaban in rat and human liver microsomes

Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states