Frontiers in Pharmacology | Drug Metabolism and Transport

Clinical Trial

Published on 17 Apr 2025

The pharmacokinetics and Concentration-QTc analysis of a new etomidate analog ET-26-HCl: a phase I trial in healthy Chinese subjects

in Drug Metabolism and Transport

Kun He
Wenyu Zhang
Xiangran Kong
Lize Li
Lei Diao
Qing Wen
Guohai Su
Xiaoran Yang
Hongyan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534717

181 views

Clinical Trial

Accepted on 16 Apr 2025

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers

in Drug Metabolism and Transport

YIKE WANG
Dai Li
Tong Zhang
Sumei Xu
Yanxin Zhang
Kaijing Zhao
Shaorong Li
Kai Shen
Xiaomin Li
Pingsheng Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563556

Original Research

Accepted on 16 Apr 2025

Liquid chromatography tandem mass spectrometry assay for the simultaneous determination of apalutamide and its active metabolite N-desmethyl apalutamide, and application in real world patients with castration-resistant prostate cancer

in Drug Metabolism and Transport

Yuxuan Zhu
Lu Chen
Wenqiang Chen
Dingyuan Yang
Lijuan Zhang
Jun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510583

Original Research

Published on 16 Apr 2025

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein

in Drug Metabolism and Transport

Gang Zhao
Yajuan Li
Mengyuan Liu
Wei Chang
Hui Shen
Junhui Xue
Fengzhou Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564174

213 views

Review

Published on 16 Apr 2025

The role of transcytosis in the blood-retina barrier: from pathophysiological functions to drug delivery

in Drug Metabolism and Transport

Chun-Lin Zhang
Jing-Jie Ma
Xiang Li
Hai-Qing Yan
Yong-Kun Gui
Zhi-Xin Yan
Ming-Feng You
Ping Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565382

198 views

Original Research

Accepted on 14 Apr 2025

Hydroxychloroquine increases the exposure of methotrexate in plasma and red blood cells: A Pharmacokinetic Interaction Study in Rats In Vivo

in Drug Metabolism and Transport

Guijie Zhang
Rui Wang
Geping Chen
Simin Liu
Hongyu Jie
Wenying Chen
Qiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1561001

Clinical Trial

Published on 14 Apr 2025

Bioequivalence and safety assessment of sorafenib tosylate tablets in healthy Chinese subjects under fasting conditions

in Drug Metabolism and Transport

Zhaoyu Wang
Hong Peng
Yun Zhang
Xijing Chen
Jiye A

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1470095

234 views

Original Research

Accepted on 11 Apr 2025

Prediction of pharmacokinetic/pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model

in Drug Metabolism and Transport

Mengjun Zhang
Keheng Wu
Sihui Long
Xiong Jin
Bo Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578117

Original Research

Published on 11 Apr 2025

Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism

in Drug Metabolism and Transport

Mai Han
Gang Cui
Yan Zhao
Xianbo Zuo
Xiaoxue Wang
Xin Zhang
Na Mi
Jiangli Jin
Chunyan Xiao
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505557

824 views

Original Research

Published on 11 Apr 2025

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

in Drug Metabolism and Transport

Alexander Lenard
Simon A. Hermann
Felicitas Stoll
Juergen Burhenne
Kathrin I. Foerster
David Czock
Gerd Mikus
Andreas D. Meid
Walter E. Haefeli
Antje Blank

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542063

681 views

Original Research

Accepted on 10 Apr 2025

Impact of CYP3A4 Functional Variability on Ziprasidone Metabolism

in Drug Metabolism and Transport

Qi Zhou
Yameng Wu
Zhize Ye
Zheyan Zhang
Kai Zheng
Jianchang Qian
Zhongxiang Xiao
Yang Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585040

Original Research

Published on 10 Apr 2025

A mechanistic quantitative systems pharmacology model platform for translational efficacy evaluation and checkpoint combination design of bispecific immuno-modulatory antibodies

in Drug Metabolism and Transport

Yiyang Xu
Siyuan Yang
Qi Rao
Yuan Gao
Guanyue Zhou
Dongmei Zhao
Xinsheng Shi
Yi Chai
Chen Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571844

396 views

Original Research

Accepted on 08 Apr 2025

Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study

in Drug Metabolism and Transport

Fei Wang
Ze Li
Youqi Huang
Qin Liu
Honghong Wang
Libin Zhao
Hongjin Gao
Mingyu Chen
Yuze Lin
Xingang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574949

Original Research

Published on 08 Apr 2025

In vivo effects of bempedoic acid on microdosed CYP probe drugs

in Drug Metabolism and Transport

Felicitas Stoll
Salvatore Amato
Jürgen Burhenne
Antje Blank

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544956

249 views

Original Research

Published on 04 Apr 2025

Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients

in Drug Metabolism and Transport

Huilin Xu
Mingming Li
Houshan Yao
Guoliang Chen
Jiani Chen
Xinyun Hou
Hong Yang
Chenghang Yu
Zeshuai Lin
Jiawei Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517446

277 views

Original Research

Accepted on 02 Apr 2025

A High-Efficiency Automatic Pressure-Relief Drug Transfer Device for Anticancer Medications with Superior Closed Performance

in Drug Metabolism and Transport

Liming Xie
Guanfeng Chen
Qianqian Ouyang
Weiyan Quan
Xiaoming Xie
Xiaoling Chen
Lefan Li
Sidong Li
Rizhi Chen
Rongqiong Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579771