Frontiers in Pharmacology | Drug Metabolism and Transport

Original Research

Published on 11 Apr 2025

Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism

in Drug Metabolism and Transport

Mai Han
Gang Cui
Yan Zhao
Xianbo Zuo
Xiaoxue Wang
Xin Zhang
Na Mi
Jiangli Jin
Chunyan Xiao
Jing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505557

415 views

Original Research

Published on 11 Apr 2025

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

in Drug Metabolism and Transport

Alexander Lenard
Simon A. Hermann
Felicitas Stoll
Juergen Burhenne
Kathrin I. Foerster
David Czock
Gerd Mikus
Andreas D. Meid
Walter E. Haefeli
Antje Blank

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542063

221 views

Original Research

Accepted on 10 Apr 2025

Impact of CYP3A4 Functional Variability on Ziprasidone Metabolism

in Drug Metabolism and Transport

Qi Zhou
Yameng Wu
Zhize Ye
Zheyan Zhang
Kai Zheng
Jianchang Qian
Zhongxiang Xiao
Yang Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585040

Original Research

Published on 10 Apr 2025

A mechanistic quantitative systems pharmacology model platform for translational efficacy evaluation and checkpoint combination design of bispecific immuno-modulatory antibodies

in Drug Metabolism and Transport

Yiyang Xu
Siyuan Yang
Qi Rao
Yuan Gao
Guanyue Zhou
Dongmei Zhao
Xinsheng Shi
Yi Chai
Chen Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571844

162 views

Original Research

Accepted on 08 Apr 2025

Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study

in Drug Metabolism and Transport

Fei Wang
Ze Li
Youqi Huang
Qin Liu
Honghong Wang
Libin Zhao
Hongjin Gao
Mingyu Chen
Yuze Lin
Xingang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574949

Original Research

Published on 08 Apr 2025

In vivo effects of bempedoic acid on microdosed CYP probe drugs

in Drug Metabolism and Transport

Felicitas Stoll
Salvatore Amato
Jürgen Burhenne
Antje Blank

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544956

192 views

Original Research

Published on 04 Apr 2025

Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients

in Drug Metabolism and Transport

Huilin Xu
Mingming Li
Houshan Yao
Guoliang Chen
Jiani Chen
Xinyun Hou
Hong Yang
Chenghang Yu
Zeshuai Lin
Jiawei Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517446

226 views

Original Research

Accepted on 02 Apr 2025

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of Organic Cation Transporter 1 and P-glycoprotein

in Drug Metabolism and Transport

Gang Zhao
Yajuan Li
Mengyuan Liu
Wei Chang
Hui Shen
Junhui Xue
Fengzhou Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564174

Original Research

Accepted on 02 Apr 2025

A High-Efficiency Automatic Pressure-Relief Drug Transfer Device for Anticancer Medications with Superior Closed Performance

in Drug Metabolism and Transport

Liming Xie
Guanfeng Chen
Qianqian Ouyang
Weiyan Quan
Xiaoming Xie
Xiaoling Chen
Lefan Li
Sidong Li
Rizhi Chen
Rongqiong Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579771

Clinical Trial

Accepted on 01 Apr 2025

Bioequivalence and safety assessment of sorafenib tosylate tablets in healthy Chinese subjects under fasting conditions

in Drug Metabolism and Transport

Wang Zhaoyu
peng hong
zhang yun
Xijing Chen
Jiye Aa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1470095

Review

Accepted on 31 Mar 2025

The role of transcytosis in the blood-retina barrier: from pathophysiological functions to drug delivery

in Drug Metabolism and Transport

Chun-lin Zhang
Jing-Jie Ma
Xiang Li
Hai-Qing Yan
Yong-Kun Gui
Zhi-Xin Yan
Ming-feng You
Ping Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565382

Clinical Trial

Accepted on 31 Mar 2025

The pharmacokinetics and Concentration-QTc analysis of a new etomidate analog ET-26-HCl: a phase I trial in healthy Chinese subjects

in Drug Metabolism and Transport

Kun He
Wenyu Zhang
Xiangran Kong
Lize Li
Lei Diao
QING WEN
Guohai Su
Xiaoran Yang
Hongyan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534717

Original Research

Published on 31 Mar 2025

In Vivo pharmacokinetic interactions of ribociclib with rivaroxaban and apixaban in rats: implications for increased drug exposure and dose adjustments

in Drug Metabolism and Transport

Zihan Liu
Wenyu Du
Qimin Wang
Zhi Wang
Jing An
Yinling Ma
Zhanjun Dong
Ying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530806

270 views

Original Research

Published on 31 Mar 2025

Physiologically based pharmacokinetic model of sodium-glucose cotransporter 2 inhibitors predicted pharmacokinetics and pharmacodynamics to explore dosage regimen for patients with type 2 diabetes mellitus and renal insufficiency

in Drug Metabolism and Transport

Guimu Guo
Meng Ke
Jianwen Xu
Wanhong Wu
Jiarui Chen
Chengjie Ke
Pinfang Huang
Cuihong Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520268

219 views

Original Research

Published on 28 Mar 2025

Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation

in Drug Metabolism and Transport

Md Ali Mujtaba
Md Abdur Rashid
Mangesh D. Godbole
Yahya Alhamhoom
Divyashri S. Shende
Sameer Alshehri
Mohammad J. Akbar
Mohammed Kaleem
Ujwala N. Mahajan
Naiyer Shahzad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577331

412 views

Original Research

Published on 28 Mar 2025

Influence of the ABCB1-rs1045642 gene polymorphism on blood drug concentration in voriconazole-treated patients with severe invasive fungal infection

in Drug Metabolism and Transport

Qian Zhang
Xing Gao
Dongmei Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510890

207 views