Frontiers in Pharmacology | Cardiovascular and Smooth Muscle Pharmacology

Original Research

Accepted on 03 Apr 2025

Pulmonary Artery-Targeted Low-Dose Metformin-Loaded Nanocapsules Safely Improve Pulmonary Arterial Hypertension in Rats

in Cardiovascular and Smooth Muscle Pharmacology

Ayako Chida-Nagai
Naoki Masaki
Hiroki Sato
Tatsuya Kato
Emi Takakuwa
Yoshihiro Matsuno
Atsushi Manabe
Atsuhito Takeda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577570

Original Research

Accepted on 03 Apr 2025

Major Risk Factors Underlying the Development of Metabolic Syndrome in Vitamin D-Deficient Rats

in Cardiovascular and Smooth Muscle Pharmacology

Fatemah O Kamel
Shereen K Mahjoub
Mai A A Sattar Ahmad
Maha H Jamal
Duaa M Bakhshwin
Abdulhadi S Burzangi
Soad A Shaker
Rania M Magadmi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573332

Review

Published on 02 Apr 2025

Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology

in Cardiovascular and Smooth Muscle Pharmacology

Luwen Zhang
Wei Wang
Xincan Liu
Kuipo Yan
Qiang Li
Ming Li
Chunying Li
Yanxin Li
Lei Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1499060

285 views

Original Research

Published on 02 Apr 2025

LncRNA MEG3 exacerbates diabetic cardiomyopathy via activating pyroptosis signaling pathway

in Cardiovascular and Smooth Muscle Pharmacology

Shengnan Zhuo
Yifeng Liu
Siyuan Wang
Zhuoling Chen
Xuran Shi
Yangjunna Zhang
Dengfeng Xu
Jingjin Hu
Yin Wang
Xuefeng Qu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538059

296 views

Original Research

Published on 01 Apr 2025

Deciphering the causality of gut microbiota, circulating metabolites and heart failure: a mediation mendelian

in Cardiovascular and Smooth Muscle Pharmacology

Xueqing Guan
Chaonan Sun
Jianyao Su
Zhijun Sun
Cheng Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531384

344 views

Original Research

Published on 31 Mar 2025

Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals

in Cardiovascular and Smooth Muscle Pharmacology

Chisom Soremekun
Daudi Jjingo
David Kateete
Oyekanmi Nash
Dorothea Nitsch
Moffat Nyirenda
Dipender Gill
Eleftheria Zeggini
Harald Grallert
Annette Peters

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1436972

655 views

Review

Published on 28 Mar 2025

Diuretics: a review of the pharmacology and effects on glucose homeostasis

in Cardiovascular and Smooth Muscle Pharmacology

Mauricio Di Fulvio
Yakshkumar Dilipbhai Rathod
Shorooq Khader

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1513125

808 views

Original Research

Published on 28 Mar 2025

Vascular smooth muscle cell-derived SO2 sulphenylated interferon regulatory factor 1 to inhibit VSMC senescence

in Cardiovascular and Smooth Muscle Pharmacology

Bingquan Qiu
Shangyue Zhang
Shuang Ge
Zhengyu Yu
Deqing Wang
Kun Li
Xiaoqi Yu
Chaoshu Tang
Junbao Du
Hongfang Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1516885

488 views

Original Research

Published on 28 Mar 2025

Butylphthalide reduces plaque burden and improves neurological function in carotid atherosclerotic disease: a pooled analysis

in Cardiovascular and Smooth Muscle Pharmacology

Jia Yang
Xinhao Pei
Jianxin Qiang
Lijuan Li
Yanping Liu
Panpan Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1460338

508 views

Review

Published on 27 Mar 2025

Carfilzomib in multiple myeloma: unraveling cardiac toxicities - from mechanisms to diagnosis and management

in Cardiovascular and Smooth Muscle Pharmacology

Yi Gao
Di Zhou
Xue Bai
Yunjie Wang
Chenchen Wang
Lintao Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570017

547 views

Original Research

Published on 26 Mar 2025

Cre recombinase affects calcium dynamics already in young mice

in Cardiovascular and Smooth Muscle Pharmacology

János Levin Liffers
Jan Peter Reinhardt
Matthias Dodo Seidl
Uwe Kirchhefer
Frank Ulrich Müller
Jan Sebastian Schulte

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558573

427 views

Original Research

Published on 26 Mar 2025

Phenylephrine and the risk of atrial fibrillation in critically ill patients: a multi-centre study from eICU database

in Cardiovascular and Smooth Muscle Pharmacology

ZhiMing Huang
Weichao Li
WeiXian Xie
Gu xun-hu
Heng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1478961

378 views

Editorial

Published on 25 Mar 2025

Editorial: Mendelian randomization and cardiovascular remodeling

in Cardiovascular and Smooth Muscle Pharmacology

Jianxin Qiang
Jia Yang
Yanwu Liu
Ji Zhang
Hao Sun
Lijuan Li
Duo Wang
Yanping Liu
Panpan Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593325

473 views

Review

Published on 21 Mar 2025

Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

in Cardiovascular and Smooth Muscle Pharmacology

Muneer Ahmed Khoso
Heng Liu
Tong Zhao
Wenjie Zhao
Qiang Huang
Zeqi Sun
Khuzin Dinislam
Chen Chen
Lingyi Kong
Yong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524584

943 views

Original Research

Published on 20 Mar 2025

Semaglutide attenuates myocardial ischemia-reperfusion injury by inhibiting ferroptosis of cardiomyocytes via activation of PKC-S100A9 axis

in Cardiovascular and Smooth Muscle Pharmacology

Yan Liu
Zixuan Li
Xinhe Xu
Yan Zou
Miaomiao Zhang
Yingyu Chen
Wenwu Zhu
Bing Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529652

765 views

Review

Published on 20 Mar 2025

Takeda G protein–coupled receptor 5 (TGR5): an attractive therapeutic target for aging-related cardiovascular diseases

in Cardiovascular and Smooth Muscle Pharmacology

Yufeng He
Siqi Liu
Yali Zhang
Yumei Zuo
Keming Huang
Li Deng
Bin Liao
Yi Zhong
Jian Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1493662

605 views