Frontiers in Pharmacology

Original Research

Accepted on 07 Apr 2025

7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B

in Experimental Pharmacology and Drug Discovery

Fengxiao Hao
Mengnan Zeng
Bing Cao
Xiwen Liang
Zhiyou Hao
Kaili Ye
Xinmian Jiao
Weisheng Feng
Xiaoke Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545566

Review

Accepted on 07 Apr 2025

Towards the Elimination of Infectious HPV: Exploiting CRISPR/Cas Innovations

in Pharmacology of Infectious Diseases

Wei Liu
Min Wang
Shiyan Xu
Wei Zhang
Jinjing Qin
Pan Liu
Lianhai Jin
Donghai Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528568

Original Research

Accepted on 07 Apr 2025

The Mechanistic Study of Codonopsis pilosula on Laryngeal Squamous Cell Carcinoma Based on Network Pharmacology and Experimental Validation

in Pharmacology of Anti-Cancer Drugs

Huina Guo
Yichen Lou
Xiaofang Hou
Guan Xiaoya
Yujia Guo
Han Qi
Xuting Xue
Ying Wang
Long He
Zhongxun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542116

Original Research

Accepted on 07 Apr 2025

Sodium Aescinate Promotes Apoptosis of Pancreatic Stellate Cells and Alleviates Pancreatic Fibrosis by Inhibiting the PI3K/Akt/FOXO1 Signaling Pathways

in Gastrointestinal and Hepatic Pharmacology

Qing-Yun Wang
Bai-Yan Xu
Yi Wang
Yan-Mei Lin
Lin-Fu Zheng
Gang Liu
Da-Zhou Li
Chuan-Shen Jiang
Wen Wang
Xiang-Peng Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554260

Review

Accepted on 07 Apr 2025

Parthenolide: Pioneering New Frontiers in Hematological Malignancies

in Pharmacology of Anti-Cancer Drugs

Azadeh Omidkhoda
Elmira Zarei
Ayda Zarei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534686

Original Research

Accepted on 07 Apr 2025

Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice

in Gastrointestinal and Hepatic Pharmacology

Rui Tang
Quan Ji
Pengyuan Kang
Ling Jiang
Yuan Liu
Pengyu Miao
Xiaofan Xu
Mingxi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572906

Systematic Review

Accepted on 07 Apr 2025

Assessing the Therapeutic Potential of Rutin in Alleviating Symptoms of Inflammatory Bowel Disease: A Meta-Analysis

in Gastrointestinal and Hepatic Pharmacology

Ruicheng Yan
Zhenkai Zou
Fanglian Zhang
Zhigang Pan
Jinyao Xu
Xuanyi Li
Xiangjun Sun
Xufeng Wang
Feng Qin
Abulikemu Abulizi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539469

Mini Review

Accepted on 07 Apr 2025

Research progress of ferroptosis and PARP inhibitor in ovarian cancer ： action mechanism and resistance mechanism

in Pharmacology of Anti-Cancer Drugs

Jiqing Zhang
Mu Liu
Yuting Xiang
Zhongjun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1598279

Original Research

Accepted on 07 Apr 2025

Acute and Subacute Toxicity Evaluation of ZhenzhuXiaoji Decoction in Preclinical Models: Implications for Safe Clinical Use

in Predictive Toxicology

Songzhe Li
Shuchang BAO
Lingyun Cai
Baolong Li
Yue Sun
Yang Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554732

Review

Accepted on 07 Apr 2025

NLRP3 inflammasome as a therapeutic target in doxorubicin-induced cardiotoxicity: Role of phytochemicals

in Cardiovascular and Smooth Muscle Pharmacology

Xiaopeng Zhao
Lian Duan
Qian-Ru Zhao
Xing Lv
Nai-Yuan Tian
Yang Shenglei
Kun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567312

Original Research

Accepted on 07 Apr 2025

Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation

in Cardiovascular and Smooth Muscle Pharmacology

Lingling Xuan
Lulu Ren
Xiaoxu Kang
Rui Chang
Wen Zhang
Lili Gong
Lihong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1536132

Original Research

Accepted on 07 Apr 2025

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

in Experimental Pharmacology and Drug Discovery

Yuefen Lou
Wenqing Shi
Mengqi Jia
Xiao Li
Xin Zhao
Chenxi Wang
Guorong Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519054

Review

Accepted on 07 Apr 2025

Exosomes as natural vectors for therapeutic delivery of bioactive compounds in skin diseases

in Experimental Pharmacology and Drug Discovery

Somayeh Keshtkar
Haniyeh Najafi
Mozhdeh Heidari
Maryam Kaviani
Fatemeh Sabet Sarvestani
Zahra Asvar
Alimohammad Tamaddon
Maryam Sadat Sadati
Nasrin Hamidizadeh
Negar Azarpira

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485769

Original Research

Published on 07 Apr 2025

Drug-therapy-related problems and pharmacist interventions in the medical ward in northeast Ethiopia: focus on types, acceptability, and impacts

in Drugs Outcomes Research and Policies

Bedilu Linger Endalifer
Yared Dergu Ayta
Abate Wondesen Tsigie
Yehualashet Teshome Wondmkun
Mekuanint Terefe Kassa
Gedefaw Getnet Amare
Yenesew Wudu Ejigu
Manaye Tamrie Derseh
Abyou Seyfu Ambaye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558864

185 views

Original Research

Published on 07 Apr 2025

A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins

in Ethnopharmacology

Yang Chen
Fan Zhang
Wenjing Ren
Yue Zhou
Shiru Jiang
Shuo Zhang
Gui Xu
Xiutong Ge
Hui Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558298

367 views

Original Research

Published on 07 Apr 2025

Miltirone enhances the chemosensitivity of gastric cancer cells to cisplatin by suppressing the PI3K/AKT signaling pathway

in Pharmacology of Anti-Cancer Drugs

Yiping Wang
Hang Lv
Li Shen
Zhe Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553791

213 views