Frontiers in Pharmacology

Original Research

Published on 03 Apr 2025

Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

in Inflammation Pharmacology

Jiacheng Shen
Yuxuan Fang
Nan Xu
Hongyi Chen
Miao Zhu
Dan Li
Zewen Chu
Masataka Sunagawa
Yanqing Liu
Haibo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545514

674 views

Original Research

Published on 03 Apr 2025

Synergistic anticancer potential of biogenic nanoparticles and cryptomeridiol from Sphaeranthus indicus: targeting gastric cancer through apoptosis and cell cycle arrest

in Pharmacology of Anti-Cancer Drugs

Pan Zhao
Jigang Wang
Chang Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565308

424 views

Original Research

Published on 03 Apr 2025

Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism

in Ethnopharmacology

Huichao Wang
Zhongyue Huang
Guangnan Chen
Yang Li
Youwen Liu
Huijie Gu
Yujing Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548491

497 views

Review

Published on 03 Apr 2025

Protein structure prediction via deep learning: an in-depth review

in Experimental Pharmacology and Drug Discovery

Yajie Meng
Zhuang Zhang
Chang Zhou
Xianfang Tang
Xinrong Hu
Geng Tian
Jialiang Yang
Yuhua Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498662

834 views

Original Research

Published on 03 Apr 2025

Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway

in Gastrointestinal and Hepatic Pharmacology

Jiawei Zhang
Tingting Liu
Tongqing Xue
Zhongzhi Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529343

374 views

Review

Published on 03 Apr 2025

Engineered nanoparticles for the treatment of Alzheimer’s disease

in Neuropharmacology

Jia Jia
Shuang Zhao
Jinghan Zhao
Yun Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510798

627 views

Original Research

Published on 03 Apr 2025

Anticoagulation quality with warfarin therapy, and associated factors among adult outpatients at public hospitals in nekemte town, western Ethiopia: a retrospective study

in Drugs Outcomes Research and Policies

Firafan Shuma Teka
Ayana Tadesse Korsa
Habte Gebeyehu Bayisa
Dechasa Befikadu W/Senbat
Refisa Shifera Beyene
Dinka Dugassa Iticha
Birbirsa Sefera Senbeta

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544957

442 views

Original Research

Published on 03 Apr 2025

Effectiveness and safety of tenofovir amibufenamide and tenofovir alafenamide in treating elderly patients diagnosed with decompensated hepatitis B cirrhosis: a retrospective cohort study

in Pharmacology of Infectious Diseases

Xinye Qiu
Yue Yin
Shibin Zhang
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545108

371 views

Original Research

Published on 03 Apr 2025

Argatroban in patients with acute ischemic stroke with early neurological deterioration: a cost-effectiveness analysis from the perspective of Chinese healthcare system

in Drugs Outcomes Research and Policies

Yu Xie
Liping Hu
Ping Xu
Xianbin Guo
Junxiu Cai
Min Pan
Jie Tang
Qingtao Gong
Rong Su
Yake Lou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1470373

371 views

Original Research

Published on 03 Apr 2025

Circ_0098181 binds PKM2 to attenuate liver fibrosis

in Inflammation Pharmacology

Yuan-Yuan Luo
Ya-Ping Guan
Hong-Fei Zhan
Chun-Yan Sun
Ling-Yan Cai
Ke-Gong Tao
Yong Lin
Xin Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517250

422 views

Systematic Review

Published on 03 Apr 2025

Effect of compound kushen injection on immune function in patients with colorectal cancer: a systematic review and meta-analysis

in Ethnopharmacology

Lixin Zhang
Guangyan Wei
Kaiping Wang
Xu Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565031

584 views

Review

Published on 03 Apr 2025

Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review

in Neuropharmacology

Wei She
Junxiao Su
Wenji Ma
Guohai Ma
Jianfu Li
Hui Zhang
Cheng Qiu
Xingyong Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557133

675 views

Original Research

Published on 03 Apr 2025

Transdermal delivery of traditional Chinese medicine patch vs. NSAIDs patch for alleviating inflammation and relieving pain for early-stage knee osteoarthritis: a retrospective case control study

in Experimental Pharmacology and Drug Discovery

Shoufeng Wang
Jingtao Guan
Wanran Gong
Bingbo Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549883

380 views

Original Research

Published on 03 Apr 2025

From COPD to cancer: indacaterol’s unexpected role in combating NSCLC

in Pharmacology of Anti-Cancer Drugs

Chenghao Liu
Jiaqi Huang
Pengjie Cai
Min Jiang
Honglei Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1579126

312 views

Original Research

Published on 03 Apr 2025

Spiraea prunifolia var. simpliciflora leaves ameliorate inflammatory responses and oxidative stress in PPE/LPS-induced chronic obstructive pulmonary disease mouse model

in Respiratory Pharmacology

Ba-Wool Lee
Ji-Hye Ha
Da-Hye Yi
Ju-Hong Kim
Seong-Hun Jeong
Hyeon Jin Lee
Yun-Hye Kim
Hyung-Jun Kwon
Ji-Young Park
Woo Sik Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501731

541 views

Review

Accepted on 02 Apr 2025

Anti-atherosclerotic effects and molecular targets of Salvianolic Acids from Salvia miltiorrhiza

in Ethnopharmacology

Qingzhi Liang
Xiaoqin Liu
Xin Xu
Zhengtao Chen
Ting Luo
Su Yi
Hongyan Xie
Hong Gao
chunguang Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574086