Frontiers in Pharmacology

Original Research

Published on 04 Apr 2025

Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients

in Drug Metabolism and Transport

Huilin Xu
Mingming Li
Houshan Yao
Guoliang Chen
Jiani Chen
Xinyun Hou
Hong Yang
Chenghang Yu
Zeshuai Lin
Jiawei Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517446

314 views

Review

Published on 04 Apr 2025

Acacetin as a natural cardiovascular therapeutic: mechanisms and preclinical evidence

in Cardiovascular and Smooth Muscle Pharmacology

Zihe Zhou
Tao Li
Helin Qin
Xinyu Wang
Shanshan He
Zhongcai Fan
Qiang Ye
Yanfei Du

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1493981

434 views

Original Research

Published on 04 Apr 2025

Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex

in Gastrointestinal and Hepatic Pharmacology

Qiang Li
Pan Pan
Qingqing Xian
Jingtan Li
Jingting Wang
Jiaying Cai
Jing Wang
Yanfei Jia
Haiji Sun
Lulu Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1492694

277 views

Original Research

Published on 04 Apr 2025

Endoplasmic reticulum stress aggravates ferroptosis via PERK/ATF4/HSPA5 pathway in UUO-induced renal fibrosis

in Renal Pharmacology

Zhigang Huang
Lihua Zhou
Bin Liu
Xiaoju Li
Yu Sang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545972

249 views

Original Research

Accepted on 03 Apr 2025

Hochuekkito accelerates recovery from cisplatin induced-muscle atrophy accompanied by slow-twitch fiber-specific microRNA upregulation in mice

in Ethnopharmacology

Hitomi Sekine
Chinami Matsumoto
Naoki Fujitsuka
Sachiko Mogami
Shunsuke Ohnishi
Hiroshi Takeda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1502563

Systematic Review

Accepted on 03 Apr 2025

Tailoring Dual Antiplatelet Therapy for Stroke Prevention: A Meta-Analysis of Timing, Duration, and Stroke Subtypes

in Neuropharmacology

NAIF M. ALHAWITI
Sherouk Fouda
Naser D. Alotaibi
Hassan A. Madkhali
Fahad K. Alsharef
Ashraf El-Metwally
Jamal M Alhawiti

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1516402

Original Research

Accepted on 03 Apr 2025

Pulmonary Artery-Targeted Low-Dose Metformin-Loaded Nanocapsules Safely Improve Pulmonary Arterial Hypertension in Rats

in Cardiovascular and Smooth Muscle Pharmacology

Ayako Chida-Nagai
Naoki Masaki
Hiroki Sato
Tatsuya Kato
Emi Takakuwa
Yoshihiro Matsuno
Atsushi Manabe
Atsuhito Takeda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577570

119 views

Original Research

Accepted on 03 Apr 2025

Major Risk Factors Underlying the Development of Metabolic Syndrome in Vitamin D-Deficient Rats

in Cardiovascular and Smooth Muscle Pharmacology

Fatemah O Kamel
Shereen K Mahjoub
Mai A A Sattar Ahmad
Maha H Jamal
Duaa M Bakhshwin
Abdulhadi S Burzangi
Soad A Shaker
Rania M Magadmi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573332

Original Research

Published on 03 Apr 2025

Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma

in Pharmacology of Anti-Cancer Drugs

Ruibing Wu
Hengye Yuan
Yuehua Wang
Xianggang Gou
Wanhua Hou
Zhongzheng Zhou
Xinran Wang
Xiuling Deng
Changshan Wang
Haisheng Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541298

408 views

Original Research

Published on 03 Apr 2025

Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations

in Inflammation Pharmacology

Jiacheng Shen
Yuxuan Fang
Nan Xu
Hongyi Chen
Miao Zhu
Dan Li
Zewen Chu
Masataka Sunagawa
Yanqing Liu
Haibo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545514

674 views

Original Research

Published on 03 Apr 2025

Synergistic anticancer potential of biogenic nanoparticles and cryptomeridiol from Sphaeranthus indicus: targeting gastric cancer through apoptosis and cell cycle arrest

in Pharmacology of Anti-Cancer Drugs

Pan Zhao
Jigang Wang
Chang Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565308

424 views

Original Research

Published on 03 Apr 2025

Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism

in Ethnopharmacology

Huichao Wang
Zhongyue Huang
Guangnan Chen
Yang Li
Youwen Liu
Huijie Gu
Yujing Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1548491

497 views

Review

Published on 03 Apr 2025

Protein structure prediction via deep learning: an in-depth review

in Experimental Pharmacology and Drug Discovery

Yajie Meng
Zhuang Zhang
Chang Zhou
Xianfang Tang
Xinrong Hu
Geng Tian
Jialiang Yang
Yuhua Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1498662

834 views

Original Research

Published on 03 Apr 2025

Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway

in Gastrointestinal and Hepatic Pharmacology

Jiawei Zhang
Tingting Liu
Tongqing Xue
Zhongzhi Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529343

374 views

Review

Published on 03 Apr 2025

Engineered nanoparticles for the treatment of Alzheimer’s disease

in Neuropharmacology

Jia Jia
Shuang Zhao
Jinghan Zhao
Yun Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510798

627 views

Original Research

Published on 03 Apr 2025

Anticoagulation quality with warfarin therapy, and associated factors among adult outpatients at public hospitals in nekemte town, western Ethiopia: a retrospective study

in Drugs Outcomes Research and Policies

Firafan Shuma Teka
Ayana Tadesse Korsa
Habte Gebeyehu Bayisa
Dechasa Befikadu W/Senbat
Refisa Shifera Beyene
Dinka Dugassa Iticha
Birbirsa Sefera Senbeta

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544957

442 views