Frontiers in Pharmacology

Original Research

Accepted on 07 Apr 2025

Sodium Aescinate Promotes Apoptosis of Pancreatic Stellate Cells and Alleviates Pancreatic Fibrosis by Inhibiting the PI3K/Akt/FOXO1 Signaling Pathways

in Gastrointestinal and Hepatic Pharmacology

Qing-Yun Wang
Bai-Yan Xu
Yi Wang
Yan-Mei Lin
Lin-Fu Zheng
Gang Liu
Da-Zhou Li
Chuan-Shen Jiang
Wen Wang
Xiang-Peng Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554260

109 views

Original Research

Accepted on 07 Apr 2025

Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice

in Gastrointestinal and Hepatic Pharmacology

Rui Tang
Quan Ji
Pengyuan Kang
Ling Jiang
Yuan Liu
Pengyu Miao
Xiaofan Xu
Mingxi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572906

Systematic Review

Accepted on 07 Apr 2025

Assessing the Therapeutic Potential of Rutin in Alleviating Symptoms of Inflammatory Bowel Disease: A Meta-Analysis

in Gastrointestinal and Hepatic Pharmacology

Ruicheng Yan
Zhenkai Zou
Fanglian Zhang
Zhigang Pan
Jinyao Xu
Xuanyi Li
Xiangjun Sun
Xufeng Wang
Feng Qin
Abulikemu Abulizi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539469

Mini Review

Accepted on 07 Apr 2025

Research progress of ferroptosis and PARP inhibitor in ovarian cancer ： action mechanism and resistance mechanism

in Pharmacology of Anti-Cancer Drugs

Jiqing Zhang
Mu Liu
Yuting Xiang
Zhongjun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1598279

122 views

Original Research

Accepted on 07 Apr 2025

Clusterin ameliorates diabetic atherosclerosis by suppressing macrophage pyroptosis and activation

in Cardiovascular and Smooth Muscle Pharmacology

Lingling Xuan
Lulu Ren
Xiaoxu Kang
Rui Chang
Wen Zhang
Lili Gong
Lihong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1536132

Original Research

Accepted on 07 Apr 2025

Comprehensive characterisation of the active ingredients of Smilax glabra Roxb based on chemical fingerprinting, metabolic fingerprinting and pharmacodynamic fingerprinting

in Experimental Pharmacology and Drug Discovery

Yuefen Lou
Wenqing Shi
Mengqi Jia
Xiao Li
Xin Zhao
Chenxi Wang
Guorong Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519054

Review

Accepted on 07 Apr 2025

Exosomes as natural vectors for therapeutic delivery of bioactive compounds in skin diseases

in Experimental Pharmacology and Drug Discovery

Somayeh Keshtkar
Haniyeh Najafi
Mozhdeh Heidari
Maryam Kaviani
Fatemeh Sabet Sarvestani
Zahra Asvar
Alimohammad Tamaddon
Maryam Sadat Sadati
Nasrin Hamidizadeh
Negar Azarpira

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485769

Review

Published on 07 Apr 2025

The outcast of medicine: metals in medicine--from traditional mineral medicine to metallodrugs

in Ethnopharmacology

Donghan Bai
Michal Nowak
Dajun Lu
Qiaochu Wang
Martin Fitzgerald
Hui Zhang
Remy MacDonald
Ziwen Xu
Lu Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542560

457 views

Original Research

Published on 07 Apr 2025

A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins

in Ethnopharmacology

Yang Chen
Fan Zhang
Wenjing Ren
Yue Zhou
Shiru Jiang
Shuo Zhang
Gui Xu
Xiutong Ge
Hui Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558298

476 views

Original Research

Published on 07 Apr 2025

Drug-therapy-related problems and pharmacist interventions in the medical ward in northeast Ethiopia: focus on types, acceptability, and impacts

in Drugs Outcomes Research and Policies

Bedilu Linger Endalifer
Yared Dergu Ayta
Abate Wondesen Tsigie
Yehualashet Teshome Wondmkun
Mekuanint Terefe Kassa
Gedefaw Getnet Amare
Yenesew Wudu Ejigu
Manaye Tamrie Derseh
Abyou Seyfu Ambaye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1558864

309 views

Original Research

Published on 07 Apr 2025

Miltirone enhances the chemosensitivity of gastric cancer cells to cisplatin by suppressing the PI3K/AKT signaling pathway

in Pharmacology of Anti-Cancer Drugs

Yiping Wang
Hang Lv
Li Shen
Zhe Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553791

318 views

Systematic Review

Published on 07 Apr 2025

A bibliometric and visual analysis based on immune checkpoint inhibitors for hepatocellular carcinoma: 2014 – 2024

in Pharmacology of Anti-Cancer Drugs

Gao-Min Liu
Rui Guo
Ji-Wei Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520055

164 views

Review

Published on 07 Apr 2025

Dual signaling pathways of TGF-β superfamily cytokines in hepatocytes: balancing liver homeostasis and disease progression

in Gastrointestinal and Hepatic Pharmacology

Roohi Chaudhary
Ralf Weiskirchen
Marcelo Ehrlich
Yoav I. Henis

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580500

256 views

Original Research

Published on 07 Apr 2025

Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia

in Pharmacogenetics and Pharmacogenomics

Min-Hui He
Xian-Hui Zhang
Ji-Hong Zhang
Jie Pan
Chao Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538888

233 views

Systematic Review

Published on 07 Apr 2025

Global trends in antimicrobial resistance of Enterococcus faecium: a systematic review and meta-analysis of clinical isolates

in Pharmacology of Infectious Diseases

Chen Huang
Samaneh Moradi
Mohammad Sholeh
Faezeh Motallebi Tabaei
Tingting Lai
Bo Tan
Jingjing Meng
Khalil Azizian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1505674

369 views

Original Research

Published on 07 Apr 2025

Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

in Experimental Pharmacology and Drug Discovery

Tilal Elsaman
Magdi Awadalla Mohamed
Abozer Y. Elderdery
Abdullah Alsrhani
Badr Alzahrani
Heba Bassiony Ghanem
Jeremy Mills
Musaed Rayzah
Nasser A. N. Alzerwi
Afnan Al-sultan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1531512

376 views