Review

Published on 03 Nov 2021

Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models

in Obstetric and Pediatric Pharmacology

Nupur Chaphekar
Prerna Dodeja
Imam H. Shaik
Steve Caritis
Raman Venkataramanan

Frontiers in Pediatrics

doi 10.3389/fped.2021.733823

14,239 views
26 citations

Original Research

Published on 29 Oct 2021

Estimated Manipulation of Tablets and Capsules to Meet Dose Requirements for Chinese Children: A Cross-Sectional Study

in Obstetric and Pediatric Pharmacology

Liwen Zhang
Yan Hu
Panpan Pan
Chengtao Hong
Luo Fang

Frontiers in Pediatrics

doi 10.3389/fped.2021.747499

3,850 views
4 citations

Original Research

Published on 18 Oct 2021

Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

in Obstetric and Pediatric Pharmacology

Xiaomei I. Liu
Dionna J. Green
John N. van den Anker
Natella Y. Rakhmanina
Homa K. Ahmadzia
Jeremiah D. Momper
Kyunghun Park
Gilbert J. Burckart
André Dallmann

Frontiers in Pediatrics

doi 10.3389/fped.2021.723006

5,316 views
8 citations

Original Research

Published on 13 Oct 2021

Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

in Obstetric and Pediatric Pharmacology

Sherry Zhao
Mary Gockenbach
Manuela Grimstein
Hari Cheryl Sachs
Mark Mirochnick
Kimberly Struble
Yodit Belew
Jian Wang
Edmund V. Capparelli
Brookie M. Best

Frontiers in Pediatrics

doi 10.3389/fped.2021.721059

4,353 views
10 citations

Original Research

Published on 01 Oct 2021

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

in Obstetric and Pediatric Pharmacology

Xiaoyan Mao
Runxiu Yin
Gaoyuan Sun
Yan Zhou
Chunhui Yang
Chunlian Fang
Yuhong Wu
Tingting Cui
Li Liu
Jiaxin Gan

Frontiers in Pediatrics

doi 10.3389/fped.2021.719803

3,694 views
8 citations

Original Research

Published on 23 Sep 2021

Evaluation of Placental Transfer and Tissue Distribution of cis- and Trans-Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

in Obstetric and Pediatric Pharmacology

Stéphane Personne
Céline Brochot
Paulo Marcelo
Aurélie Corona
Sophie Desmots
Franck Robidel
Anthony Lecomte
Véronique Bach
Florence Zeman

Frontiers in Pediatrics

doi 10.3389/fped.2021.730383

3,896 views
11 citations

Original Research

Published on 23 Sep 2021

Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

in Obstetric and Pediatric Pharmacology

Paola Mian
Bridget Nolan
John N. van den Anker
Kristel van Calsteren
Karel Allegaert
Nisha Lakhi
André Dallmann

Frontiers in Pediatrics

doi 10.3389/fped.2021.733520

3,726 views
11 citations

Original Research

Published on 20 Sep 2021

Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester

in Obstetric and Pediatric Pharmacology

Babajide Shenkoya
Shakir Atoyebi
Ibrahim Eniayewu
Abdulafeez Akinloye
Adeniyi Olagunju

Frontiers in Pediatrics

doi 10.3389/fped.2021.734122

3,817 views
8 citations

Case Report

Published on 15 Sep 2021

Case Report: A Case of Infant Bronchial Dieulafoy's Disease and Article Review

in Obstetric and Pediatric Pharmacology

Yang Chen
Yiting Mao
Xingfeng Cheng
Ruihua Xiong
Ying Lan
Feng Chen
Furong Zhang
Jun Liu
Yanting Wu

Frontiers in Pediatrics

doi 10.3389/fped.2021.674509

2,301 views
9 citations

Original Research

Published on 13 Sep 2021

Utilizing Network Pharmacology to Explore the Possible Mechanism of Coptidis Rhizoma in Kawasaki Disease

in Obstetric and Pediatric Pharmacology

Xue Fan
Xin Guo
Ying Li
Mingguo Xu

Frontiers in Pediatrics

doi 10.3389/fped.2021.708553

2,749 views
2 citations

Policy and Practice Reviews

Published on 26 Jul 2021

Regulatory Considerations for the Mother, Fetus and Neonate in Fetal Pharmacology Modeling

in Obstetric and Pediatric Pharmacology

Dionna J. Green
Kyunghun Park
Varsha Bhatt-Mehta
Donna Snyder
Gilbert J. Burckart

Frontiers in Pediatrics

doi 10.3389/fped.2021.698611

4,312 views
13 citations

Perspective

Published on 23 Jun 2021

Physiologically Based Pharmacokinetics Model in Pregnancy: A Regulatory Perspective on Model Evaluation

in Obstetric and Pediatric Pharmacology

Paola Coppola
Essam Kerwash
Susan Cole

Frontiers in Pediatrics

doi 10.3389/fped.2021.687978

5,129 views
33 citations

Case Report

Published on 23 Apr 2021

Voriconazole Induced Hallucinations and Visual Disturbances in a Female Child: A Case Report and Literature Review

in Obstetric and Pediatric Pharmacology

Rujiang Zheng
Yu Li
Chuyi Guo
Yuxin Pei
Zhiyong Ke
Libin Huang

Frontiers in Pediatrics

doi 10.3389/fped.2021.655327

6,717 views
5 citations

Brief Research Report

Published on 19 Mar 2021

Mother-to-Infant Bonding in Women With a Bipolar Spectrum Disorder

in Obstetric and Pediatric Pharmacology

Myrthe G. B. M. Boekhorst
Annemerle Beerthuizen
Manon Hillegers
Victor J. M. Pop
Veerle Bergink

Frontiers in Pediatrics

doi 10.3389/fped.2021.646985

15,439 views
6 citations

Review

Published on 23 Feb 2021

Model-Informed Precision Dosing of Antibiotics in Pediatric Patients: A Narrative Review

in Obstetric and Pediatric Pharmacology

Alan Abdulla
Elma Edwina
Robert B. Flint
Karel Allegaert
Enno D. Wildschut
Birgit C. P. Koch
Matthijs de Hoog

Frontiers in Pediatrics

doi 10.3389/fped.2021.624639

10,474 views
43 citations

Case Report

Published on 24 Nov 2020

Case Report: Infantile Ischemic Stroke and Antiphospholipid Antibodies, Description of Four Cases

in Obstetric and Pediatric Pharmacology

Teresa Giani
Angela Mauro
Giovanna Ferrara
Rolando Cimaz

Frontiers in Pediatrics

doi 10.3389/fped.2020.596386

3,836 views
5 citations

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Articles

Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models

Estimated Manipulation of Tablets and Capsules to Meet Dose Requirements for Chinese Children: A Cross-Sectional Study

Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

Evaluation of Placental Transfer and Tissue Distribution of cis- and Trans-Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model

Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

Mechanistic Modeling of Maternal Lymphoid and Fetal Plasma Antiretroviral Exposure During the Third Trimester

Case Report: A Case of Infant Bronchial Dieulafoy's Disease and Article Review

Utilizing Network Pharmacology to Explore the Possible Mechanism of Coptidis Rhizoma in Kawasaki Disease

Regulatory Considerations for the Mother, Fetus and Neonate in Fetal Pharmacology Modeling

Physiologically Based Pharmacokinetics Model in Pregnancy: A Regulatory Perspective on Model Evaluation

Voriconazole Induced Hallucinations and Visual Disturbances in a Female Child: A Case Report and Literature Review

Mother-to-Infant Bonding in Women With a Bipolar Spectrum Disorder

Model-Informed Precision Dosing of Antibiotics in Pediatric Patients: A Narrative Review

Case Report: Infantile Ischemic Stroke and Antiphospholipid Antibodies, Description of Four Cases