Original Research

Published on 25 Nov 2021

Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4+ T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis

in Cancer Molecular Targets and Therapeutics

Cynthia L. Bristow
Mary Ann B. Reeves
Ronald Winston

Frontiers in Oncology

doi 10.3389/fonc.2021.739080

3,784 views
1 citation

Original Research

Published on 24 Nov 2021

Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

in Cancer Molecular Targets and Therapeutics

Adina Gerson-Gurwitz
Nathan P. Young
Vikas K. Goel
Boreth Eam
Craig R. Stumpf
Joan Chen
Sarah Fish
Maria Barrera
Eric Sung
Jocelyn Staunton

Frontiers in Oncology

doi 10.3389/fonc.2021.766298

10,135 views
28 citations

Original Research

Published on 24 Nov 2021

Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1

in Cancer Molecular Targets and Therapeutics

Deeptashree Nandi
Pradeep Singh Cheema
Aakriti Singal
Hina Bharti
Alo Nag

Frontiers in Oncology

doi 10.3389/fonc.2021.751271

3,620 views
9 citations

Original Research

Published on 24 Nov 2021

Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers

in Cancer Molecular Targets and Therapeutics

Hitomi Sumiyoshi Okuma
Kan Yonemori
Yuki Kojima
Maki Tanioka
Kazuki Sudo
Emi Noguchi
Susumu Hijioka
Keiko Wakakuwa
Ken Kato
Akihiro Hirakawa

Frontiers in Oncology

doi 10.3389/fonc.2021.732525

4,290 views
3 citations

Original Research

Published on 23 Nov 2021

Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma

in Cancer Molecular Targets and Therapeutics

Yihang Gong
Kun Li
Yunfei Qin
Kaining Zeng
Jianrong Liu
Shaozhuo Huang
Yewu Chen
Haoyuan Yu
Wei Liu
Linsen Ye

Frontiers in Oncology

doi 10.3389/fonc.2021.711448

5,180 views
22 citations

Original Research

Published on 23 Nov 2021

SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis

in Cancer Molecular Targets and Therapeutics

Tien-Yu Huang
Sung-Sen Yang
Ching-Len Liao
Ming-Hong Lin
Hsuan-Hwai Lin
Jung-Chun Lin
Peng-Jen Chen
Yu-Lueng Shih
Wei-Kuo Chang
Tsai-Yuan Hsieh

Frontiers in Oncology

doi 10.3389/fonc.2021.733555

2,192 views
2 citations

Original Research

Published on 19 Nov 2021

Long Non-Coding RNA CCAT2 Activates RAB14 and Acts as an Oncogene in Colorectal Cancer

in Cancer Molecular Targets and Therapeutics

Dalu Wang
Zhilong Li
Hongzhuan Yin

Frontiers in Oncology

doi 10.3389/fonc.2021.751903

2,858 views
8 citations

Original Research

Published on 19 Nov 2021

Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

in Cancer Molecular Targets and Therapeutics

David M. Wilson
Matthew A. J. Duncton
Caleb Chang
Christie Lee Luo
Taxiarchis M. Georgiadis
Patricia Pellicena
Ashley M. Deacon
Yang Gao
Debanu Das

Frontiers in Oncology

doi 10.3389/fonc.2021.778925

5,842 views
10 citations

Original Research

Published on 18 Nov 2021

Anti-Tumor Effect of Apatinib and Relevant Mechanisms in Liposarcoma

in Cancer Molecular Targets and Therapeutics

Lixuan Cui
Liang Yan
Xiaoya Guan
Bin Dong
Min Zhao
Ang Lv
Daoning Liu
Zhen Wang
Faqiang Liu
Jianhui Wu

Frontiers in Oncology

doi 10.3389/fonc.2021.739139

3,646 views
6 citations

Original Research

Published on 18 Nov 2021

ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma

in Cancer Molecular Targets and Therapeutics

Farnaz Sedigheh Takhsha
Christel Vangestel
Muhammet Tanc
Sven De Bruycker
Maya Berg
Isabel Pintelon
Sigrid Stroobants
Guido R. Y. De Meyer
Pieter Van Der Veken
Wim Martinet

Frontiers in Oncology

doi 10.3389/fonc.2021.750259

3,406 views
6 citations

Original Research

Published on 18 Nov 2021

A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

in Cancer Molecular Targets and Therapeutics

Hua Yang
Mu-Zi-he Zhang
Hui-wei Sun
Yan-tao Chai
Xiaojuan Li
Qiyu Jiang
Jun Hou

Frontiers in Oncology

doi 10.3389/fonc.2021.783194

5,993 views
19 citations

Original Research

Published on 17 Nov 2021

Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

in Cancer Molecular Targets and Therapeutics

Yu Li
Keying Zhang
Fa Yang
Dian Jiao
Mingyang Li
Xiaolong Zhao
Chao Xu
Shaojie Liu
Hongji Li
Shengjia Shi

Frontiers in Oncology

doi 10.3389/fonc.2021.771036

3,265 views
9 citations

Original Research

Published on 16 Nov 2021

Identification of the Unique Clinical and Genetic Features of Chinese Lung Cancer Patients With EGFR Germline Mutations in a Large-Scale Retrospective Study

in Cancer Molecular Targets and Therapeutics

Xinqing Lin
Muyun Peng
Quanfang Chen
Mingming Yuan
Rongrong Chen
Haiyi Deng
Jiaxi Deng
Ouqi Liu
Yuqing Weng
Mingjiu Chen

Frontiers in Oncology

doi 10.3389/fonc.2021.774156

5,097 views
11 citations

Original Research

Published on 15 Nov 2021

B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma

in Cancer Molecular Targets and Therapeutics

Cheng Long
Gaowei Li
Chengyun Zhang
Tao Jiang
Yanjun Li
Xin Duan
Gang Zhong

Frontiers in Oncology

doi 10.3389/fonc.2021.659662

4,977 views
26 citations

Original Research

Published on 11 Nov 2021

Topical Application of Temperature-Sensitive Gel Containing Caerin 1.1 and 1.9 Peptides on TC-1 Tumour-Bearing Mice Induced High-Level Immune Response in the Tumour Microenvironment

in Cancer Molecular Targets and Therapeutics

Guoying Ni
Xiaosong Liu
Hejie Li
Conor E. Fogarty
Shu Chen
Pingping Zhang
Ying Liu
Xiaolian Wu
Ming Q. Wei
Guoqiang Chen

Frontiers in Oncology

doi 10.3389/fonc.2021.754770

4,507 views
9 citations

Review

Published on 11 Nov 2021

The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

in Cancer Molecular Targets and Therapeutics

Duo Yang
Na Zhang
Meihua Li
Tao Hong
Wei Meng
Taohui Ouyang

Frontiers in Oncology

doi 10.3389/fonc.2021.772134

5,638 views
18 citations

Navigation group

Articles

Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4+ T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis

Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1

Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers

Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma

SPAK Deficiency Attenuates Chemotherapy-Induced Intestinal Mucositis

Long Non-Coding RNA CCAT2 Activates RAB14 and Acts as an Oncogene in Colorectal Cancer

Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

Anti-Tumor Effect of Apatinib and Relevant Mechanisms in Liposarcoma

ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma

A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

Identification of the Unique Clinical and Genetic Features of Chinese Lung Cancer Patients With EGFR Germline Mutations in a Large-Scale Retrospective Study

B7-H3 as a Target for CAR-T Cell Therapy in Skull Base Chordoma

Topical Application of Temperature-Sensitive Gel Containing Caerin 1.1 and 1.9 Peptides on TC-1 Tumour-Bearing Mice Induced High-Level Immune Response in the Tumour Microenvironment

The Hippo Signaling Pathway: The Trader of Tumor Microenvironment