Frontiers in Molecular Biosciences

Original Research

Published on 16 Apr 2025

Structure-guided virtual screening reveals phytoconstituents as potent cathepsin B inhibitors: Implications for cancer, traumatic brain injury, and Alzheimer’s disease

in Structural Biology

Nageeb Hassan
Mohammad Furkan
Mohd Shahnawaz Khan
Azna Zuberi
Moyad Shahwan
Anas Shamsi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1581711

512 views

Brief Research Report

Published on 16 Apr 2025

In silico characterization of the interaction of AKR1B1 with the deacetylase activation domain (DAD)

in Structural Biology

Francisco J. Gómez-Zaldívar
Luis Córdova-Bahena
Angel J. Ruiz-Moreno
Paolo Ceppi
Marco A. Velasco-Velázquez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1562206

487 views

Editorial

Accepted on 14 Apr 2025

Editorial: Structural Studies of Bacteria and Viruses

in Structural Biology

Annalisa Pastore

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605596

114 views

Original Research

Published on 31 Mar 2025

Highly conserved ion binding sites are not all functionally relevant in mouse KCC4

in Structural Biology

Lisa Becker
Jens Hausmann
Rieke Wellpott
Anna-Maria Hartmann

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1556250

654 views

Original Research

Published on 10 Mar 2025

Computational electrostatic engineering of nanobodies for enhanced SARS−CoV−2 receptor binding domain recognition

in Structural Biology

Zafar Iqbal
Muhammad Asim
Umair Ahmad Khan
Neelam Sultan
Irfan Ali

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1512788

1,166 views

Correction

Published on 28 Nov 2024

Corrigendum: Shedding light on the DICER1 mutational spectrum of uncertain significance in malignant neoplasms

in Structural Biology

D. S. Bug
I. S. Moiseev
Yu. B. Porozov
N. V. Petukhova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1517143

531 views

Editorial

Published on 16 Oct 2024

Editorial: Cryogenic electron microscopy of infectious diseases

in Structural Biology

Jiho Yoo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1506197

955 views
1 citation

Original Research

Published on 15 Oct 2024

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy

in Structural Biology

Insan Habib
Md Nayab Sulaimani
Deeba Shamim Jairajpuri
Afzal Hussain
Taj Mohammad
Mohamed F. Alajmi
Anas Shamsi
Md Imtaiyaz Hassan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1492847

1,488 views
1 citation

Original Research

Published on 03 Oct 2024

Shedding light on the DICER1 mutational spectrum of uncertain significance in malignant neoplasms

in Structural Biology

D. S. Bug
I. S. Moiseev
Yu. B. Porozov
N. V. Petukhova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1441180

1,340 views
1 citation

Original Research

Published on 01 Oct 2024

Semantic segmentation-based detection algorithm for challenging cryo-electron microscopy RNP samples

in Structural Biology

J. Vargas
A. Modrego
H. Canabal
J. Martin-Benito

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1473609

984 views

Original Research

Published on 27 Sep 2024

Structure features of Streptococcus pneumoniae FabG and virtual screening of allosteric inhibitors

in Structural Biology

Kaimin Xu
Jianliang Zhong
Jing Li
Yulu Cao
Lai Wei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1472252

3,100 views

Brief Research Report

Published on 17 Sep 2024

Structural bases for blockade and activation of BK channels by Ba2+ ions

in Structural Biology

Shubhra Srivastava
Pablo Miranda
Teresa Giraldez
Jianghai Zhu
Raul E. Cachau
Miguel Holmgren

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1454273

1,076 views

Editorial

Published on 02 Sep 2024

Editorial: New approaches toward understanding challenges in molecular virology: computational techniques and machine learning

in Structural Biology

Srirupa Chakraborty
Kun Qu
Jayaraman Valadi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1472796

1,030 views

Editorial

Published on 26 Aug 2024

Editorial: Prediction of protein-protein interactions (PPIs): the next frontier

in Structural Biology

Amar Singh
Binh P. Nguyen
Ho Leung Ng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1479705

1,134 views

Original Research

Published on 30 Jul 2024

Candidate proteins interacting with cytoskeleton in cells from the basal airway epithelium in vitro

in Structural Biology

Olusola A. Olatona
Sayantan R. Choudhury
Ray Kresman
Carol A. Heckman

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1423503

2,092 views

Review

Published on 30 Jul 2024

AlphaFold2 in biomedical research: facilitating the development of diagnostic strategies for disease

in Structural Biology

Hong Zhang
Jiajing Lan
Huijie Wang
Ruijie Lu
Nanqi Zhang
Xiaobai He
Jun Yang
Linjie Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1414916

4,730 views