Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 28 Apr 2025

MRI-based deep learning with clinical and imaging features to differentiate medulloblastoma and ependymoma in children

in Molecular Diagnostics and Therapeutics

Yasen Yimit
Parhat Yasin
Yue Hao
Abudouresuli Tuersun
Chencui Huang
Xiaoguang Zou
Ya Qiu
Yunling Wang
Mayidili Nijiati

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1570860

129 views

Review

Published on 28 Apr 2025

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic response

in Molecular Diagnostics and Therapeutics

Haiqi Lu
Zelin Lu
Yufei Wang
Miaoqin Chen
Guangliang Li
Xian Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1604313

183 views

Original Research

Published on 25 Apr 2025

Mechanism study on the treatment of ulcerative colitis by Gegen Qinlian nano-preparation through promoting M2 macrophage polarization

in Molecular Diagnostics and Therapeutics

Jilei Li
Jiarui Cao
Zhenyu Zhang
Sizhe Wang
Meng Zhu
Lili Yang
Wenhui Ouyang
Chunzheng Ma

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580874

254 views

Original Research

Published on 25 Apr 2025

Risk factors of colorectal cancer in middle-aged and elder adults in China: findings from the China health and retirement longitudinal study

in Molecular Diagnostics and Therapeutics

Lin Zhang
Yuyan Zhang
Yujia Huo
Yang Zhao
Aimin Xu
Zhining Liu
Qiaojun Hong
Huiming Tu
Junjie Huang
Li Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1333834

296 views

Original Research

Published on 24 Apr 2025

TNFAIP8L3 regulation of the TGF-β signaling pathway affects the proportion of macrophages during tumor antigen presentation and affects the prognosis of ovarian cancer

in Molecular Diagnostics and Therapeutics

Chaomin Yue
Xiao Zheng
Yuqing Ye
Danyang Li
Yanhong Zhou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1566363

418 views

Review

Published on 24 Apr 2025

The oxidative-stress-senescence axis in keratoconus: new insights into corneal degeneration

in Molecular Diagnostics and Therapeutics

Maria Laura Passaro
Michele Rinaldi
Valentina Morgera
Antonia Feola
Vito Romano
Mario Troisi
Diego Strianese
Raffaele Piscopo
Samantha Messina
Antonella Romano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1539542

316 views

Original Research

Accepted on 23 Apr 2025

A Glutamine Metabolism Gene Signature with Prognostic and Predictive Value for Colorectal Cancer Survival and Immunotherapy Response

in Molecular Diagnostics and Therapeutics

Yinmeng Zhang
He Zhu
Jiawei Fan
Jiahui Zhao
yan xia
Nan Zhang
Hong Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1599141

Original Research

Published on 23 Apr 2025

Systematic use of protein free energy changes for classifying variants of uncertain significance: the case of IFT140 in Mainzer-Saldino Syndrome

in Molecular Diagnostics and Therapeutics

Macarena Gajardo
José Luis Guerrero
Bárbara Poblete
Esperanza Bayyad
Ignacio Castro
Jorge Maturana
Jaime Tobar
Víctor Faúndes
Paola Krall

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1561380

330 views

Brief Research Report

Accepted on 22 Apr 2025

Clinical and Molecular Implications of cGAS/STING Signaling in Checkpoint Inhibitor Immunotherapy

in Molecular Diagnostics and Therapeutics

Hao Chen
Yang Zhong
Rongjie Feng
Xingyu Zhu
Kang Xu
Mingjie Kuang
Wei Chong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1556736

101 views

Review

Accepted on 22 Apr 2025

Engineered Exosomes: A Promising Drug Delivery Platform with Therapeutic Potential

in Molecular Diagnostics and Therapeutics

Jinyu Zhang
Genevieve Mo Schwarz
Xuechen Ren
Wen Xie
Haitao Guo
Yong Jiang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583992

Original Research

Accepted on 22 Apr 2025

Identification of key genes CCL5, PLG, LOX and C3 in clear cell renal cell carcinoma through integrated bioinformatics analysis

in Molecular Diagnostics and Therapeutics

Weiming Deng
Xie Zhenwei
Cheng Feng
Yude Hong
Libo Chen
Mingyong Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1587196

135 views

Original Research

Accepted on 22 Apr 2025

Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimer's disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
LAIBAIK PARK
Fangmin Yu
Garrett Sommer Sommer
Clara Woods
Teresa A Milner
Michael J Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597130

124 views

Original Research

Accepted on 21 Apr 2025

Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Jingyun Jin
Shuyan Qin
Fu Qiang
Changzhi Yu
Hongjin Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580880

126 views

Original Research

Accepted on 21 Apr 2025

Integrative Multi-omics and Mendelian Randomization Analysis Reveal SPP1 + Tumor-Associated Macrophage-Driven Prognostic Signature for Hepatocellular Carcinoma

in Molecular Diagnostics and Therapeutics

Kai Lei
Yichun Lei
Yaoze Wang
Zhixin Ye
Jiawei Liu
Wenhao Chen
Caihong Zhou
Jinmei Tan
Shuxian Chen
Yifan Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1594610

111 views

Review

Accepted on 21 Apr 2025

The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies

in Molecular Diagnostics and Therapeutics

Yong-wang Li
Yu Liu
Sheng-Zhen Luo
Xiao-Juan Huang
Yan Shen
Wei-Si Wang
Zhi-Chen Lang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1585758

Original Research

Accepted on 18 Apr 2025

New Biomarkers of Kawasaki Disease Identified by Gingival Crevicular Fluid Proteomics

in Molecular Diagnostics and Therapeutics

Xue Fan
Ying Li
Mingguo Xu
Guo Xin
Jingjing Lan
Yuehao Xu
Jianqing Lin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597412