Frontiers in Molecular Biosciences

Original Research

Published on 19 Dec 2024

Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics

in Molecular Diagnostics and Therapeutics

Adrian Thornton
Rajesh Komati
Hogyoung Kim
Jamiah Myers
Kymmia Petty
Rion Sam
Elijah Johnson-Henderson
Keshunna Reese
Linh Tran
Vaniyambadi Sridhar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1481912

548 views

Original Research

Published on 18 Dec 2024

Biomarker discovery and development of prognostic prediction model using metabolomic panel in breast cancer patients: a hybrid methodology integrating machine learning and explainable artificial intelligence

in Metabolomics

Fatma Hilal Yagin
Yasin Gormez
Fahaid Al-Hashem
Irshad Ahmad
Fuzail Ahmad
Luca Paolo Ardigò

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1426964

587 views

Review

Published on 17 Dec 2024

Application of machine learning for mass spectrometry-based multi-omics in thyroid diseases

in Metabolomics

Yanan Che
Meng Zhao
Yan Gao
Zhibin Zhang
Xiangyang Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1483326

745 views

Original Research

Accepted on 16 Dec 2024

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes

in Lipids, Membranes and Membranous Organelles

Yunus E Dogan
Niharika Bala
Erika S Galban
Russell L Lewis
Nancy Denslow
Sihong Song
Abdel A Alli

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1485506

105 views

Original Research

Accepted on 16 Dec 2024

Decoding oral cancer: Insights from miRNA expression profiles and their regulatory targets

in RNA Networks and Biology

Xin Wang
Shuang Zhang
Tao Cao
Hong Fan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1521839

Brief Research Report

Accepted on 13 Dec 2024

Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression

in Molecular Diagnostics and Therapeutics

Shankar Suman
Wendy Nevala
Alexey Leontovich
James W Jakub
Liyi Geng
Sarah McLaughlin
Svetomir N Markovic

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1522717

Original Research

Accepted on 12 Dec 2024

Opportunities, challenges and difficulties in NMR-based metabolomics applied to neovascular Age-related Macular Degeneration (nAMD) patients' follow-up

in Metabolomics

Matthieu Schoumacher
Vincent Lambert
Pierre Blaise
Bénédicte Locht
Michéle Thys
Edouard Duchateau
Etienne Cavalier
Jean-Marie Rakic
Agnès Noël
Pascal De Tullio

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1449226

Original Research

Published on 12 Dec 2024

Independent evolution of oleate hydratase clades in Bacillales reflects molecular convergence

in Molecular Evolution

Robert J. Neff
Priscilla C. Lages
Shannon K. Donworth
James D. Brien
Christopher D. Radka

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1485485

900 views

Original Research

Published on 12 Dec 2024

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

in Molecular Recognition

Priya Antony
Bincy Baby
Ranjit Vijayan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1514759

328 views

Original Research

Published on 11 Dec 2024

Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Li-Wei Zhang
Ji Yang
Hua-Wei Jiang
Xiu-Qiang Yang
Ya-Nan Chen
Wei-Dang Ying
Ying-Liang Deng
Min-hui Zhang
Hai Liu
Hong-Lei Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1524517

552 views

Original Research

Published on 11 Dec 2024

Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis

in Genome Organization and Dynamics

Dayan Hu
Jieliang Jian
Jinpeng Zhang
Xiaojun Xu
Shu Wang
Cuiping Gong
Yuanqin Zhang
Pengcan Zhu
Zhimin Gu
Wenzhi Guan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1499220

476 views

Original Research

Published on 11 Dec 2024

Integrated multi-omics analysis describes immune profiles in ischemic heart failure and identifies PTN as a novel biomarker

in Molecular Diagnostics and Therapeutics

Ting Xiong
Quhuan Li
Yifan Wang
Ying Kong
Hailin Li
Jie Liu
Yueheng Wu
Fengxia Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1524827

447 views

Correction

Published on 11 Dec 2024

Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition

in RNA Networks and Biology

Bashdar Mahmud Hussen
Hamed Shoorei
Mahdi Mohaqiq
Marcel E. Dinger
Hazha Jamal Hidayat
Mohammad Taheri
Soudeh Ghafouri-Fard

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1524742

399 views

Original Research

Published on 09 Dec 2024

Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics

in Molecular Diagnostics and Therapeutics

Andong Guo
Chenrui Wu
Jishuang Cao
Kejia Zhu
Sentai Ding

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1521889

468 views

Review

Published on 09 Dec 2024

Development of anti-cancer drugs for tumor-associated macrophages: a comprehensive review and mechanistic insights

in Molecular Diagnostics and Therapeutics

Bingjun Bai
Shangzhi Xie
Ya Wang
Fei Wu
Yao Chen
Jia Bian
Xing Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1463061

688 views

Original Research

Published on 09 Dec 2024

Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation

in Cellular Biochemistry

Ankit P. Laddha
Aniket Wahane
Raman Bahal
José E. Manautou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1498946

760 views

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Articles

Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics

Biomarker discovery and development of prognostic prediction model using metabolomic panel in breast cancer patients: a hybrid methodology integrating machine learning and explainable artificial intelligence

Application of machine learning for mass spectrometry-based multi-omics in thyroid diseases

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes

Decoding oral cancer: Insights from miRNA expression profiles and their regulatory targets

Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression

Opportunities, challenges and difficulties in NMR-based metabolomics applied to neovascular Age-related Macular Degeneration (nAMD) patients' follow-up

Independent evolution of oleate hydratase clades in Bacillales reflects molecular convergence

Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling

Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning

Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis

Integrated multi-omics analysis describes immune profiles in ischemic heart failure and identifies PTN as a novel biomarker

Corrigendum: The impact of non-coding RNAs in the epithelial to mesenchymal transition

Clinical significance of HER2 in urothelial carcinoma and analysis of its correlation with glycolytic metabolic characteristics

Development of anti-cancer drugs for tumor-associated macrophages: a comprehensive review and mechanistic insights

Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation