Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 25 Apr 2025

Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models

in Vaccines and Molecular Therapeutics

Giuditta De Lorenzo
Rapeepat Tandavanitj
Lorena Preciado-Llanes
Ricardo Sanchez-Velazquez
Raissa Prado Rocha
Young Chan Kim
Arturo Reyes-Sandoval
Arvind H. Patel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578427

112 views

Review

Accepted on 24 Apr 2025

Applying computational protein design to therapeutic antibody discovery - current state and perspectives

in Vaccines and Molecular Therapeutics

Weronika Bielska
Igor Jaszczyszyn
Paweł Dudzic
Bartosz Janusz
Dawid Chomicz
Sonia Wrobel
Victor Greiff
Ryan Feehan
Jared Adolf-Bryfogle
Konrad Krawczyk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571371

Original Research

Published on 24 Apr 2025

Regulatory cytokines modulate early isotype-specific response associated with COVID-19 survival

in Vaccines and Molecular Therapeutics

Sebastián Castro-Trujillo
Juanita Castro-Meneses
María Clemencia Rojas
Marcela Castro-Amaya
Giovani Lastra
Carlos F. Narváez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543626

428 views

Review

Accepted on 23 Apr 2025

The Recent advances in vaccine adjuvants

in Vaccines and Molecular Therapeutics

Jiayin Xing
Xiangxiang Zhao
Xiaotian Li
Ren Fang
Mingrui Sun
Yang Zhang
Ningning Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557415

Original Research

Accepted on 23 Apr 2025

Unveiling Reverse Vaccinology and Immunoinformatics Towards Saint Louis Encephalitis Virus: A Ray of Hope for Vaccine Development

in Vaccines and Molecular Therapeutics

Prasanna Srinivasan Ramalingam
Mahalakshmi Aranganathan
Md Sadique Hussain
Sujatha Elangovan
Gayathri Chellasamy
Purushothaman Balakrishnan
Mekala Janaki Ramaiah
Kyusik Yun
SIVAKUMAR A

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576557

107 views

Original Research

Accepted on 23 Apr 2025

Avidity of pertussis toxin antibodies following vaccination with genetically versus chemically detoxified pertussis toxin-containing vaccines during pregnancy

in Vaccines and Molecular Therapeutics

Bahaa Abu-Raya
Giuseppe Del Giudice
Anita H.J. Van Den Biggelaar
Yuxiao Tang
Niranjan Bhat
Hong Thai Pham
Wassana Wijagkanalan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569151

112 views

Original Research

Published on 23 Apr 2025

Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella

in Vaccines and Molecular Therapeutics

Ti Lu
Skyler T. Kramer
Mary A. York
Mst Nusrat Zahan
Debaki R. Howlader
Zackary K. Dietz
Sean K. Whittier
Nathan J. Bivens
Alexander Jurkevich
Lyndon M. Coghill

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577040

265 views

Original Research

Accepted on 22 Apr 2025

Immunoinformatic-driven design and evaluation of multi-epitope mRNA vaccine targeting HIV-1 gp120

in Vaccines and Molecular Therapeutics

Muhammad Zeeshan Ahmed
Tazeen Rao
Zeeshan Mutahir
Sarfraz Ahmed
Najeeb Ullah
Suvash Chandra Ojha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1480025

Original Research

Accepted on 22 Apr 2025

Ten years after introduction of NADC30-like strain in China: A novel chimeric porcine reproductive and respiratory syndrome vaccine candidate

in Vaccines and Molecular Therapeutics

Weixin Wu
Xinyu Fang
Yiyao Jiang
Jiameng Hu
Qiongqiong Zhou
Peng Gao
Yongning Zhang
Xinna Ge
Jun Han
Xin Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585197

175 views

Original Research

Accepted on 21 Apr 2025

Retrospective Analysis of Sex-Disaggregated Immune Responses to ALVAC-HIV and Bivalent Subtype C gp120/MF59 HIV Vaccines

in Vaccines and Molecular Therapeutics

Cassie G Ackerley
Srilatha Edupuganti
Chenchen Yu
Alison C Roxby
Kelly Seaton
Linda-Gail Bekker
Mary Allen
Stephen De Rosa
Nicole Yates
Jack Heptinstall

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557009

123 views

Systematic Review

Published on 17 Apr 2025

Effectiveness of nirsevimab immunization against RSV infection in preterm infants: a systematic review and meta-analysis

in Vaccines and Molecular Therapeutics

Xiaopeng Wang
Li Kong
Xueou Liu
Panpan Wu
Lulu Zhang
Fangrui Ding

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581970

1,100 views

Original Research

Published on 16 Apr 2025

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection

in Vaccines and Molecular Therapeutics

Giacomo Vezzani
Viola Viviani
Martina Audagnotto
Alessandro Rossi
Paolo Cinelli
Nicola Pacchiani
Chiara Limongi
Laura Santini
Fabiola Giusti
Sara Tomei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565862

708 views

Original Research

Accepted on 15 Apr 2025

The MVA-VP2-NS1-2A-NS2-Nt vaccine candidate provides heterologous protection in sheep against Bluetongue virus

in Vaccines and Molecular Therapeutics

Luis Jiménez-Cabello
Sergio Utrilla-Trigo
Miguel Illescas-Amo
Karen Rodríguez-Sabando
Julio Benavides
Javier Ortego
EVA CALVO-PINILLA

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566225

140 views

Correction

Accepted on 15 Apr 2025

Corrigendum: Enhancing Cell-Mediated Immunity through Dendritic Cell Activation: The Role of Tri-GalNAc-Modified PLGA-PEG Nanoparticles Encapsulating SR717

in Vaccines and Molecular Therapeutics

Yang Gong
Hongbin Jia
Wenrui Dang
Ting Zhou
Pu He
Xiaolei Wang
Bingdong Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590490

102 views

Original Research

Accepted on 15 Apr 2025

Fc-Effector Functional Antibody Assays for SARS-CoV-2 Variants of Concern

in Vaccines and Molecular Therapeutics

Xuemin Chen
Grace Li
Caroline Ciric
Theda Gibson
Larry J Anderson
Christina A. Rostad

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571835

189 views

Systematic Review

Accepted on 15 Apr 2025

Immunogenicity Risk Assessment for Tailored Mitigation and Monitoring of Biotherapeutics During Development: Recommendations from the European Immunogenicity Platform

in Vaccines and Molecular Therapeutics

Joanna Grudzinska-Goebel
Karin Benstein
Karien Bloem
Kyra J. Cowan
Boris Gorovits
Maria Jadhav
Melody Janssen
Vibha Jawa
Andrea Kiessling
Daniel Kramer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581153

144 views