Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Accepted on 01 Apr 2025

An immune cell activation signature reflected hepatocellular carcinoma heterogeneity and predicted clinical outcomes

in Cancer Immunity and Immunotherapy

Xiaofeng Wang
Dongli Liu
Shuai Wang
Rui He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534611

Review

Accepted on 01 Apr 2025

The impact of the tumor microenvironment on macrophages

in Cancer Immunity and Immunotherapy

Xiaoduan Li
Man Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572764

Original Research

Accepted on 01 Apr 2025

The malignant signature gene of cancer-associated fibroblasts serves as a potential prognostic biomarker for colon adenocarcinoma patients

in Cancer Immunity and Immunotherapy

Hao Zhang
Zirui Zhuang
Li Hong
Ruipeng Wang
Jinjing Xu
Youyuan Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589678

Original Research

Accepted on 01 Apr 2025

Artificial Intelligence-Assisted RNA-Binding Protein Signature for Prognostic Stratification and Therapeutic Guidance in Breast Cancer

in Cancer Immunity and Immunotherapy

Yunxia Zhao
Li Li
Shuqi Yuan
Zixin Meng
Jiayi Xu
Zhaogen Cai
Yijing Zhang
Xiaonan Zhang
Tao Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583103

Original Research

Accepted on 01 Apr 2025

Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics

in Cancer Immunity and Immunotherapy

Yuexi Yu
Huiru Liu
Kaipeng Liu
Meiqi Zhao
Yiyan Zhang
Runci Jiang
Fengmei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570378

Original Research

Accepted on 01 Apr 2025

Dual Targeting of EZH2 and PD-L1 in Burkitt's Lymphoma Enhances Immune Activation and Induces Apoptotic Pathway

in Cancer Immunity and Immunotherapy

Yurim Jeong
Hyewon Jang¹
Se Been Kim
Minseo Yu
Ra Eun Kim
Wan-Su Choi
Youngwoo Jeon
Jung-Yeon Lim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578665

Original Research

Accepted on 01 Apr 2025

Trifunctional antibody-cytokine fusion protein formats for tumortargeted combination of IL-15 with IL-7 or IL-21

in Cancer Immunity and Immunotherapy

Annika M Möller
Sarah Vettermann
Felix Baumann
Max Pütter
Dafne Müller

Frontiers in Immunology

doi 10.3389/fimmu.2025.1498697

Review

Published on 01 Apr 2025

In the era of targeted therapy and immunotherapy: advances in the treatment of large B-cell lymphoma of immune-privileged sites

in Cancer Immunity and Immunotherapy

Haotian Wang
Ying Zhang
Xin Wan
Zhaoxia Li
Ou Bai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547377

321 views

Original Research

Published on 01 Apr 2025

Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E

in Cancer Immunity and Immunotherapy

Junqian Zhang
Xiaobo Zhang
Ruixin Wu
Chang-Sheng Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569088

217 views

Original Research

Published on 01 Apr 2025

Moringa oleifera leaves protein suppresses T-lymphoblastic leukemogenesis via MAPK/AKT signaling modulation of apoptotic activation and autophagic flux regulation

in Cancer Immunity and Immunotherapy

Xiaoxue Liu
Hao Yang
Shanna Xie
Xinyu Wang
Yang Tian
Shuang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1546189

260 views

Review

Published on 01 Apr 2025

Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies

in Cancer Immunity and Immunotherapy

Reshmi Nair
Veena Somasundaram
Anshu Kuriakose
Shiv Ram Krishn
David Raben
Rachel Salazar
Pradip Nair

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548234

404 views

Review

Published on 01 Apr 2025

Adoptive immune cell therapy for colorectal cancer

in Cancer Immunity and Immunotherapy

Chenxiao Liu
Nan Liu
Tongcun Zhang
Yanyang Tu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557906

266 views

Case Report

Published on 01 Apr 2025

Immune checkpoint inhibitor-induced anti-Hu antibody-associated gastrointestinal pseudo-obstruction: a case report and literature review

in Cancer Immunity and Immunotherapy

Guang-Qing Shi
Heng-Ning Lian
Xue Wang
Jie-Qiang Xia
Huan Wang
Li-Jie Ma
Zhen-Liang Xiao
Jing Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555790

195 views

Review

Published on 01 Apr 2025

The role of the tumor microenvironment in HNSCC resistance and targeted therapy

in Cancer Immunity and Immunotherapy

Zhaomeng Guo
Kang Li
Xiaotong Ren
Xijia Wang
Dunhui Yang
Shibo Ma
Xianhai Zeng
Peng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1554835

251 views

Case Report

Published on 01 Apr 2025

Successful triple therapy for advanced synchronous multiple primary esophageal carcinoma with metal stenting, photodynamic and comprehensive systemic therapies—shining light on hope: a case report and literature review

in Cancer Immunity and Immunotherapy

Dan Zou
Ying Yan
Yifan Li
Huanhuan Ma
Yuping Bai
Xueyan Wang
Bofang Wang
Yunpeng Wang
Jingwei Ma
Hao Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580616

186 views

Systematic Review

Published on 01 Apr 2025

Toward the benefit and value of immune treatment beyond progression in lung cancer? Insights from a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Rui Huangfu
Kun Hou
Jie Zhao
Shikui Wu
Yaodong Ping

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547978

248 views