Frontiers in Immunology

Original Research

Published on 09 Apr 2025

Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana

in Vaccines and Molecular Therapeutics

Iuliana Caras
Irina-Elena Ionescu
Ana-Maria Pantazica
André van Eerde
Hege Steen
Inger Heldal
Sissel Haugslien
Catalin Tucureanu
Raluca-Elena Chelmus
Vlad-Constantin Tofan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1479689

477 views

Original Research

Published on 09 Apr 2025

Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

in Systems Immunology

Danielle Dias Munhoz
Dennyson Leandro M. Fonseca
Igor Salerno Filgueiras
Haroldo Dutra Dias
Helder I. Nakaya
Igor Jurisica
Hans D. Ochs
Lena F. Schimke
Luiz Vicente Rizzo
Otavio Cabral-Marques

Frontiers in Immunology

doi 10.3389/fimmu.2025.1509805

446 views

Systematic Review

Published on 09 Apr 2025

Vitamin supplementation and its effect on incident type 1 diabetes mellitus and islet autoimmunity: a systematic review and meta-analysis

in Nutritional Immunology

Chen Ee Low
Nicole Shi Min Chew
Sounak Rana
Sean Loke
Run Ting Chin
Shih Ling Kao
Ainsley Ryan Yan Bin Lee
Sen Hee Tay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1505324

561 views

Original Research

Accepted on 08 Apr 2025

IFN-γ-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy

in Cancer Immunity and Immunotherapy

Zihao Cai
KELIN MENG
Taiyan Yu
Yu Xi
Zhiwei Yuan
Xue Wang
Congjian Wang
Lequn Li
Xiangning Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1551322

113 views

Original Research

Accepted on 08 Apr 2025

A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses

in Vaccines and Molecular Therapeutics

Peter Battisti
Matthew R Ykema
Darshan N Kasal
Madeleine Farber Jennewein
Samuel Beaver
Abbie E Weight
Derek Hanson
Jasneet Singh
Julie Bakken
Noah Cross

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569454

102 views

Original Research

Accepted on 08 Apr 2025

Acetylcholine from Tuft Cells Promotes M2 Macrophages Polarization in Hirschsprung-Associated Enterocolitis

in Mucosal Immunity

Ziyi Zheng
Lin Lin
Huifang Lin
Jie Zhou
Zhe Wang
Chen Jianxin
Caimin Lai
Renfu Li
Zhiyong Shen
Ming Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1559966

214 views

Original Research

Accepted on 08 Apr 2025

Analysis of humoral and cellular immune activation up to 21 months after heterologous and homologous COVID-19 vaccination

in Vaccines and Molecular Therapeutics

Davide Torre
Chiara Orlandi
Ilaria Conti
Simone Barocci
Eugenio Carlotti
Mauro Magnani
Anna Casabianca
Giuseppe Stefanetti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579163

165 views

Original Research

Accepted on 08 Apr 2025

A Serum Biomarker Panel and Miniarray Detection System for Tracking Disease Activity and Flare Risk in Lupus Nephritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chenling Tang
Gongjun Tan
Aygun Teymur
Jiechang Guo
Arturo Haces-Garcia
Weihang Zhu
Richard Williams
Jing Ning
Ramesh Saxena
Tianfu Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541907

123 views

Original Research

Accepted on 08 Apr 2025

Osteopontin Regulates Right Ventricular Failure through Integrin αvβ3/PERK/CHOP-Dependent Inflammatory and Apoptotic Pathways

in Inflammation

Xiaomei Yang
Xuyang Wang
Kai Li
Qiming Deng
Yonghao Hou
Guangmin Xi
Kangping Lu
ZiHua Liu
Yu Bai
Jianbo Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569210

Original Research

Accepted on 08 Apr 2025

The administration sequences of immune checkpoint inhibitors and chemotherapy cause discrete efficacy when treating non-small cell lung cancer: a retrospective study

in Cancer Immunity and Immunotherapy

Bicheng Zhang
Yuxiao Song
Qian Min
Weiting Chen
Jun Wang
Yang Fu
Jiaxin Yin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579420

Mini Review

Accepted on 08 Apr 2025

Metabolic Reprogramming and Immune Microenvironment Characteristics in Laryngeal Carcinoma: Advances in Immunotherapy

in Cancer Immunity and Immunotherapy

Kexin Ma
Qingjie Mao
Bing Fei
Tingting Ni
Zhenxin Zhang
Haosheng Ni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589243

Original Research

Accepted on 08 Apr 2025

A Comprehensive Pan-Cancer Analysis of LRFN4: Its Potential as a Prognostic Biomarker and Therapeutic Target for Immunotherapy

in Cancer Immunity and Immunotherapy

yinmei yinmei xu
xin wu
peng zhi
Guo Genyu
yankan fu
Lukuan You
siyuan huai
Jianxiong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539076

Original Research

Accepted on 08 Apr 2025

Pan-Cancer Analysis Identifies tRNA Modification Enzyme CTU2 as a Novel Tumor Biomarker and Its Role in Immune Microenvironment

in Cancer Immunity and Immunotherapy

Jiaojiao Wang
Chang Gao
Junyi Zhang
Huahong Luo
Siqi Dai
Jianwei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547794

182 views

Review

Accepted on 08 Apr 2025

CAR-NK cell therapy for autoimmune diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Bangdong Gong
Shengnan Pan Shengnan Pan
Jiamin Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1559581

164 views

Case Report

Accepted on 08 Apr 2025

Complete Remission of a High-risk, Locally Advanced Cervical Cancer with Para-aortic Lymph Node Metastases Treated with First-line Tislelizumab plus Bevacizumab Combined with Chemotherapy Followed by Radiotherapy with Maintenance Therapy: a Case Report

in Cancer Immunity and Immunotherapy

Juan Lang
Qianqian Liu
Rong Ji
Miao Qiu
Siben Wang
Qingmeng Liu
Daping Li
Ping Chen
Zhongkui Xiong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1573202

Mini Review

Accepted on 08 Apr 2025

AMY-101 as Complement C3 Inhibitor for Periodontitis Therapy: Mechanisms, Efficacy, and Clinical Translation

in Inflammation

Jialun Li
Zhi Xu
Wayne Nishio Ayre
Xiaohan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587126