Frontiers in Immunology

Original Research

Published on 04 Apr 2025

Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs

in Cancer Immunity and Immunotherapy

Hang Deng
Xu Wang
Zi-Ang Jiang
Jian Xu
Yu Zhang
Yao Zhou
Jun Gong
Xiang-Yu Lu
Yi-Fu Hou
Hao Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541252

Case Report

Published on 04 Apr 2025

Case Report: Successful use of emapalumab in adult B-cell acute lymphoblastic leukemia experiencing severe neurotoxicity and hemophagocytic lymphohistiocytosis-like features after CAR-T cell therapy

in Cancer Immunity and Immunotherapy

Beatrice Manghisi
Giulia Cotilli
Marilena Fedele
Paola Perfetti
Elisabetta Terruzzi
Luisa Verga
Lorenza Maria Borin
Andrea Carrer
Monica Fumagalli
Maria Beatrice Ferrari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563736

Case Report

Published on 04 Apr 2025

Switching to ublituximab from prior anti-CD20 monoclonal antibody therapy: a case report series

in Multiple Sclerosis and Neuroimmunology

Regina Berkovich
Jonathan Calkwood
Heidi Crayton
April Erwin
Simon Faissner
Ralf Gold
Joshua Katz
Mark Leekoff

Frontiers in Immunology

doi 10.3389/fimmu.2025.1527102

384 views

Original Research

Published on 04 Apr 2025

Marsupial cathelicidins: characterization, antimicrobial activity and evolution in this unique mammalian lineage

in Molecular Innate Immunity

Emma Peel
Adele Gonsalvez
Carolyn J. Hogg
Katherine Belov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524092

Original Research

Published on 04 Apr 2025

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

in T Cell Biology

Daniil K. Lukyanov
Valeriia V. Kriukova
Kristin Ladell
Irina A. Shagina
Dmitry B. Staroverov
Bella E. Minasian
Anna S. Fedosova
Pavel Shelyakin
Oleg N. Suchalko
Alexander Y. Komkov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536302

147 views

Review

Published on 04 Apr 2025

The role of immune checkpoints PD-1 and CTLA-4 in cardiovascular complications leading to heart failure

in Inflammation

Shoulian Huang
Yu Kang
Ting Liu
Yan Xiong
Zixuan Yang
Qing Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561968

Original Research

Published on 04 Apr 2025

CD47 regulates antigen modulation and red blood cell clearance following an incompatible transfusion

in Alloimmunity and Transplantation

Ryan P. Jajosky
Mischa L. Covington
Jun Liu
Li Chai
Patricia E. Zerra
Satheesh Chonat
Sean R. Stowell
Connie M. Arthur

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548548

Review

Published on 04 Apr 2025

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations

in Cancer Immunity and Immunotherapy

Yixin Fu
Yong Yi
Yongxiang Shao
Jingcheng Jiang
Qingshan Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561388

Review

Published on 04 Apr 2025

Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

in Cancer Immunity and Immunotherapy

Marina Gergues
Rafijul Bari
Sharmila Koppisetti
Anna Gosiewska
Lin Kang
Robert J. Hariri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565278

101 views

Original Research

Published on 04 Apr 2025

Development and validation of a disulfidptosis-related genes signature for predicting outcomes and immunotherapy in acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Han Gong
Ying Zhang
Xusheng Wu
Yiming Pan
Mingwei Wang
Xiaofeng He
Jing Liu
Zhong Liu
Ling Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513040

Original Research

Published on 04 Apr 2025

Identification and validation of HOXC6 as a diagnostic biomarker for Ewing sarcoma: insights from machine learning algorithms and in vitro experiments

in Cancer Immunity and Immunotherapy

Yonghua Pang
Jiahui Liang
Yakai Deng
Weinan Chen
Yunyan Shen
Jing Li
Xin Wang
Zhiyao Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1449355

Review

Published on 04 Apr 2025

A novel cancer-associated lncRNA, LINC01123, participates in tumor progression, metabolism, immune escape, and resistance

in Cancer Immunity and Immunotherapy

Qiang Liu
He Huang
Shuwen Zhang
Fangteng Liu
Ting Lou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1480447

Original Research

Published on 04 Apr 2025

HLA-mismatched stem cell microtransplant prolonged overall survival and promoted immunological reconstitution for multiple myeloma

in Cancer Immunity and Immunotherapy

Yangyang Lei
Bo Cai
Zhiqing Liu
Anli Xie
Jianhui Qiao
Yi Wang
Xinrui Chen
Fei Peng
Yingxin Zhao
Jiaxin Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1509588

Brief Research Report

Published on 04 Apr 2025

A selective C5a-derived peptidomimetic enhances IgG response following inactivated SARS-CoV-2 immunization and confers rapid disease resolution following murine coronavirus infection

in Vaccines and Molecular Therapeutics

Andrew J. Neville
Mackenzie E. Conrin
Thomas T. Schulze
Paul H. Davis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1470034

124 views

Brief Research Report

Published on 04 Apr 2025

Hyperhomocysteinemia in Takayasu arteritis—genetically defined or burden of the proinflammatory state?

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Eduarda Bonelli Zarur
Faustino Peron Filho
Allan Chiaratti de Oliveira
Gerson Dierley Keppeke
Vânia D’Almeida
Alexandre Wagner Silva de Souza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574479

Original Research

Published on 04 Apr 2025

Bibliometric analysis and knowledge mapping of diabetes mellitus combined with tuberculosis research: trends from 1995 to 2023

in Microbial Immunology

Yufeng Li
Ruizi Ni
Yajing An
Ling Yang
Zhaoyang Ye
Li Zhuang
Linsheng Li
Liang Wang
Wenping Gong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571123