Frontiers in Drug Discovery

Review

Published on 13 Jul 2023

Targeting proteases and proteolytic processing of unusual N-terminal extensions of Plasmodium proteins: parasite peculiarity

in Anti-Infective Agents

Ankita Tehlan
Abhik Saha
Suman Kumar Dhar

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1223140

1,661 views

Mini Review

Published on 12 Jul 2023

FAIR data management: what does it mean for drug discovery?

in Technologies and Strategies to Enable Drug Discovery

Yojana Gadiya
Vassilios Ioannidis
David Henderson
Philip Gribbon
Philippe Rocca-Serra
Venkata Satagopam
Susanna-Assunta Sansone
Wei Gu

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1226727

2,432 views
6 citations

Original Research

Published on 07 Jul 2023

The tumor suppressor 5A2, a synthetic miR-7-5p mimic, targets oncogenic and metabolic pathways, as revealed by transcriptome-wide analysis

in Anti-Cancer Drugs

Marion T. J. van den Bosch
Bryony J. Telford
Sanaz Yahyanejad
Thijs de Gunst
Harm C. den Boer
Rogier M. Vos
Chantal L. Duurland
Rianne Biemans
Ludwig J. Dubois
Laurens A. H. van Pinxteren

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1181637

1,373 views

Review

Published on 21 Jun 2023

Yin-yang in drug discovery: rethinking de novo design and development of predictive models

in In silico Methods and Artificial Intelligence for Drug Discovery

Ana L. Chávez-Hernández
Edgar López-López
José L. Medina-Franco

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1222655

4,664 views
4 citations

Original Research

Published on 15 Jun 2023

MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites

in Anti-Infective Agents

Jersley D. Chirawurah
Bridget Adikah
Felix Ansah
Elizabeth Laryea-Akrong
Harry Danwonno
Collins M. Morang’a
Daniel Dosoo
Lucas Amenga-Etego
Gordon A. Awandare
Yaw Aniweh

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1190471

1,782 views
1 citation

Review

Published on 01 Jun 2023

Lessons that can be learned from the SARS-CoV-2 pandemic and their impact on the prophylaxis and treatment development for neglected tropical arboviruses

in Anti-Infective Agents

Danilo Rosa-Nunes
Danilo B. M. Lucchi
Robert Andreata-Santos
Luiz Mario R. Janini
Carla Torres Braconi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1176768

3,829 views

Mini Review

Published on 24 May 2023

Drug discovery and development: introduction to the general public and patient groups

in Technologies and Strategies to Enable Drug Discovery

Natesh Singh
Philippe Vayer
Shivalika Tanwar
Jean-Luc Poyet
Katya Tsaioun
Bruno O. Villoutreix

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1201419

136,877 views
74 citations

Review

Published on 10 May 2023

The critical role of mode of action studies in kinetoplastid drug discovery

in Anti-Infective Agents

Alan H. Fairlamb
Susan Wyllie

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1185679

2,836 views
5 citations

Original Research

Published on 09 May 2023

Generation of a potent anti-PD-L1-CD47 bispecific antibody with a strong therapeutic and safety profile for cancer immunotherapy

in Anti-Cancer Drugs

Irene Tang
Lauren Schwimmer
Shenda Gu
Wei Wei Prior
Hieu Van Tran
Allan Chan
Anna McClain
Christopher C. Fraser
Chunyan Sun
Meimei Si

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1182146

4,138 views
1 citation

Editorial

Published on 27 Feb 2023

Editorial: Development/repurposing of drugs to tackle the multiple variants of SARS-CoV-2

in Anti-Infective Agents

Dinorah Gambino

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1157688

1,016 views
2 citations

Brief Research Report

Published on 21 Feb 2023

Numaswitch, a biochemical platform for the efficient production of disulfide-rich pepteins

in Neurological Drugs

Bach-Ngan Nguyen
Florian Tieves
Florian G. Neusius
Hansjörg Götzke
Lutz Schmitt
Christian Schwarz

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1082058

3,009 views
1 citation

Original Research

Published on 10 Feb 2023

HMM-based profiling identifies the binding to divalent cations and nucleotides as common denominators of suramin targets

in Anti-Infective Agents

Dennis A. Hauser
Pascal Mäser

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1112992

1,529 views

Original Research

Published on 08 Feb 2023

Identification of novel genetic variants, including PIM1 and LINC01491, with ICD-10 based diagnosis of pulmonary arterial hypertension in the UK Biobank cohort

in Cardiovascular and Hematologic Drugs

Alex Pu
Gautam Ramani
Yi-Ju Chen
James A. Perry
Charles C. Hong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1127736

3,601 views
6 citations

Original Research

Published on 20 Jan 2023

In silico identification of potential inhibitors of acyl carrier protein reductase and acetyl CoA carboxylase of Plasmodium falciparum in antimalarial therapy

in In silico Methods and Artificial Intelligence for Drug Discovery

Elliasu Y. Salifu
James Abugri
Issahaku A. Rashid
Festus Osei
Joseph Atia Ayariga

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1087008

2,956 views
6 citations

Original Research

Published on 12 Jan 2023

The use of cyclic peptide antigens to generate LRP8 specific antibodies

in Technologies and Strategies to Enable Drug Discovery

Maria A. Argiriadi
Kangwen Deng
David Egan
Lei Gao
Farid Gizatullin
John Harlan
Denise Karaoglu Hanzatian
Wei Qiu
Ruth Villanueva
Andrew Goodearl

Frontiers in Drug Discovery

doi 10.3389/fddsv.2022.1093153

2,814 views
4 citations

Brief Research Report

Published on 09 Jan 2023

Determination of nucleoside DOT1L inhibitors’ residence times by τRAMD simulations

in In silico Methods and Artificial Intelligence for Drug Discovery

Carlos D. Flores-León
Luis Fernando Colorado-Pablo
Miguel Á. Santos-Contreras
Rodrigo Aguayo-Ortiz

Frontiers in Drug Discovery

doi 10.3389/fddsv.2022.1083198

1,764 views
1 citation